ID A0A0V1BDL6_TRISP Unreviewed; 788 AA.
AC A0A0V1BDL6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=UDP-N-acetylglucosamine 4-epimerase {ECO:0000256|ARBA:ARBA00031827};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE EC=5.1.3.7 {ECO:0000256|ARBA:ARBA00013175};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN Name=Gale {ECO:0000313|EMBL:KRY34755.1};
GN ORFNames=T01_9779 {ECO:0000313|EMBL:KRY34755.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY34755.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY34755.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY34755.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC galactosamine; Xref=Rhea:RHEA:20517, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:67138; EC=5.1.3.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000014};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY34755.1}.
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DR EMBL; JYDH01000062; KRY34755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1BDL6; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR GO; GO:0003974; F:UDP-N-acetylglucosamine 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF00858; ASC; 1.
DR Pfam; PF01370; Epimerase; 1.
DR PRINTS; PR01713; NUCEPIMERASE.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 441..706
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 788 AA; 89355 MW; FA7508C9D2E48698 CRC64;
MGSVNTWYSS LSLTERLLWA AVFFIATGFI FYCWTAIDWT FSDNGPGTTI LHVKKQSMHF
PPLLLCTRQP FNSKYIRQDP IFNSRFDKYA EKLISFSSAV KIQDLAGNEI EKLEKLYSTS
FNKTQERETE VDCFLPSDHF LKCIQIIKNV TSGAEILDVS SFCQNSSTLI TGFLNPCTVI
FPSEQKIPSD LGALKIELEL QKEQLTVSPA EFSGFEIYVG DLTVEEPFLP KIALKNNQAA
SLKLEIIEYI SSVSSKDFEE NRQALFKIET LKNCVYQSIK DECNCVLPFI CTKPDDSISI
PLCTVNDYKN CTASLGTNTL EIINHFDQFQ MPCLMKESTA NDIQFNCIAT RLPDIDTQTL
RYRATFSIYY DHFDYFQIKQ AQLDSIKIFI LYGIPLAVVT ALLLIALKYN MVKRVGKRPY
SDDYLETSET SMYIMPTRKS ILVTGAGGFI GSHVVLELLE NNYNVIAIDT FDNCVRGERY
PVSLERVMEL TGKRFRFYDA DVLSKETLLE IFKQHRIDSV MHFAGLKAVG ESISKPLEYY
WTNVGGALTL LRAMKEEHIN NLIFSSSATV YGPPKQLPIN EEQEIGCGLT NPYGRSKFFI
EQILEDFHAA NTEWNIISLR YFNPVGAHPS GLIGEDPTSM PNNLMPNISK AAAGKIPALR
IFGNDYDTVD GTGVRDYIHV VDLAKGHVAA LQKLHENAGY KVYNLGNGKG YSVLQLVEQF
ERSCGRKIPY VIENRRPGDL AEIYCDNTLA RNELNWTPKY DLQQMCVDTW NWQQKNPDGY
VSSEMESE
//
