ID A0A0V1BJ16_TRISP Unreviewed; 2396 AA.
AC A0A0V1BJ16;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Disks large-like protein 5 {ECO:0000313|EMBL:KRY37189.1};
GN Name=DLG5 {ECO:0000313|EMBL:KRY37189.1};
GN ORFNames=T01_7525 {ECO:0000313|EMBL:KRY37189.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY37189.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY37189.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY37189.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY37189.1}.
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DR EMBL; JYDH01000036; KRY37189.1; -; Genomic_DNA.
DR eggNOG; KOG0708; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF00625; Guanylate_kin; 2.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00072; GuKc; 2.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 2.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 912..987
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1006..1070
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1606..1686
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1753..1819
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1921..2101
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 2217..2381
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 125..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 652..714
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 786..813
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 849..921
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 195..219
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2396 AA; 266741 MW; 4CD335523CE87C60 CRC64;
MEVGCPVLKS SCDKFVPKFN DCNHFLFCGE FYYSPAATAA AVAFVLFYKL FCCLTSLGFF
AVMHHLFACG TFFSLVSLVT ELGARDVDVA VGEESCSGAV CHSSTAASEE SQDCIWTLSE
QPNDSTNELL GTGTDAGSGM LADADSKPEL KRKTGDAEEA NLNLEISRQA ETRSTATVLV
KRELSPCALM ASVQEQEEEE LEEEEEEGDD DDDDVVEEPA ESATPYQQMG GHSGGRLPPF
GQFGRSHELP PSLCMPWLSW SPVGRDRHAS SSSYTHGDTI PKMRSSACVG MGGGLSSGAG
LTGVTVGGGS ASASLGQRDL DMSVGQLATV VANVQNKRWS VAGAGPELTL LRVKLDDVQR
ELCELQSKHE LMTLEYQDVL NELDCCRASK ERLEMELHDC RLEAVKSKGD VELLVQQKQL
AERQAMELQL QLQARQAELD DLRRQHAEID NKDHRHYHHH QRRRDHEQQQ QQQQQQQQQQ
QQQQQQLQKH EQLIASTLMV EYEQACAEVA GLKDRCRLLE AETVELGSAL RLAQDECRHI
RAGRERDLEQ HRLKISSFEE CQVSLYQQLH KIAQQRDILR SENDMLKQQL QDLCGDMTSC
CCIIVRSMAS FVDEELWQEN LNVRQKHEEA MRVLRRQHDG VLSEYRHVMS ERDSVLKENE
RLSEEKGNLL KKVKSSESDR HALIEQLKTV EAQIEAVRQE RDALQQQLKA RDEQLRDRLL
AVASAYATAS GRQMRQVDAV VDNGMNPYMD PDQSITSEES VSELTSTTNA TTTPNSAVGR
CADADYDKLR RLADGLDEEL TLVRQEVEAA KQQRDWALGE RQRIVSERES MRSMCDNLRK
ERDDAITRLA VAIRDSDEIM RQKDQAEREI RKIKEKIEMD ERRVTNVEST PSNSHDSAID
ADMAEWEVET LELNMNGAQK NEDLGLELRG GRDDPVFGQL VPIYVTSVAV GSRLDGVLRT
YDCIMMVNNI DVSLMERRSV MDILRNSSAV KMVIKRRRLV GMKLISVPLA AASDGDVGIV
FEDGVYVSKI KTSSAAAKAG HLAVGDRLVY INDVPVENRS ASTVEELVRS FNGCGLVLAV
VKSPPVMSPI TPSSSTFPFQ TSLHSSSAQM KHQDSCANCQ STAAAAAAVV VTKQKRDFAV
QVSFVVTETH APVKKYESLF DKMHDKIFGR SERKATVRAA AAVPIDTTDT PNESSKRWHN
GQNSDRRARP SSVYSCYTVV DRSNSKGGVT AEQQVLQQLD SILEASEREC DSKNNNNNNN
KALLLGVMNS ERSGGGTWPK YKPNVNGSGV EMANVANGTV EPSPPLASAP APAPDKFAGR
RSALQAFHGK IVDKQSAVES RLRNTFAKRS SKIRSTEARP VSYHPTSVIS GQYSLIGSKF
SARPMSPLVG GNIHSTSSSS PSDDSPPQCL SLDSTAASSP LHHAAAGHKV CGNFATNTNI
DRINLAYYGN HLNQGNHGRP GSLMMFKPNL QLHVAHAMPV VTNTTNSNNN NRYSPCLAFD
HQSPMASHIH DQDVDQRSYA SQSSGSRGAA AVAGLFGSAA GDHQQCSSKS LHRLDAGRYH
PAIHSLSRTK RVSNKLERVI PLHSFSSDEY NNQCGGGRLI KGDVRTLHIE KRSSHEGLGI
SVASSGNGVF VSSVSENSLA ARHGLQVGDQ LLEVCGINMR SANIQHASNV LSHLGRSEQI
TLMVQYNPNR YTREMTDYHS VCSTPRATPS SMLSTQGSKA FMSQDSSLQS TSATQSHELL
TGSHCSIHYE PRFVFLKRDS DDWGFTLIGG NAIGIFVDDV KPAVACVVGP DTLRTGDQIL
EFDGVNFRKL TLEQALMEIG QRSVGSEVSV LVQYNDSSAI LEEEFLFKRS GSEISTVEGT
STEGGGGSRR GTIRRSLKFI RRSSRSSHQR TPSKESRDLE SDSTIIDELY QRVERLDYKQ
KRPLLLLGTL VDVIVAKLLE DYPKMFVQCV PECVKPMPVP ALEQGLLQNL YVDYRKRDKL
FEITRVAVVK DLIDKGYHCI LHVNPLAIER LHRLQIYPVV IFVKFKNFKQ IKELCDDRLS
SKQAKEMFEN AAKVEAECHH LFSGYQKCKR GAGDSFYVRV TVDRQAENTD ELSFRSGDIL
RVDNTVFNGV AGLWRAWLVD QEGRERSCGI IPSKNRLEEE FLFKRSGSEI STVEGTSTEG
GGGSRRGTIR RSLKFIRRSS RSSHQRTPSK ESRDLESDST IIDELYQRVE RLDYKQKRPL
LLLGTLVDVI VAKLLEDYPK MFVQCVPECV KPMPVPALEQ GLLQNLYVDY RKRDKLFEIT
RVAVVKDLID KGYHCILHVN PLAIERLHRL QIYPVVIFVK FKNFKQIKEL CDDRLSSKQA
KEMFENAAKV EAECHHLFSA TIHGPHHSIK HICQQIACTV EHEQKKTLWI ISGDTM
//
