ID A0A0V1BME4_TRISP Unreviewed; 1295 AA.
AC A0A0V1BME4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX8 {ECO:0000313|EMBL:KRY37928.1};
GN ORFNames=T01_6075 {ECO:0000313|EMBL:KRY37928.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY37928.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY37928.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY37928.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY37928.1}.
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DR EMBL; JYDH01000029; KRY37928.1; -; Genomic_DNA.
DR STRING; 6334.A0A0V1BME4; -.
DR InParanoid; A0A0V1BME4; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KRY37928.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776}.
FT DOMAIN 243..313
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 560..725
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 743..923
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 78..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..228
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1295 AA; 147537 MW; BCA6949D5A6CBE0C CRC64;
MEEMERLQYI SLVSKICTEL ENHLGLSDKD LAEFIIHLGQ KNPTFESFKS ALESNGAEFD
NSLISNLLRR IQLMTKPTGK SEDAAENASH MLSMSSKSDR EVMKQCLPAL AMPNKPVSET
LSELENLIPQ WRRENEIEQK ANIGHGSRDE RKKRERLHSR DRSSSRDSSE RRAERRRARR
RRSSSSSGES SKKHSSRGGR RRRRRSRSRS ELRTKGVHSR RRSRSGERIS RIRIKLDDTP
TVGKIYDGRV NSLRDFGCFV ELFGLRRHVE GLVHISQMKD ERVNAVSDVV TRGQKVKVKV
LASSGNRTSL SMREVDQETG EDLNPTEDVD QEDQHFDETL QLRNPDLPSA AQQKLMQLQA
EEFKASTSKR TKRLSSPERW ELKQMMAASC ISTADLPDFD EETGVLLQED MLDDHEEDVE
VELVEEEPQF LQGYGRVRQD LEPIKVVKNP DGSLAQAAMM QGALAKERRE QKIQQQRERG
NEQQLGRGSG SGGKSFLDPL ADGDSKYSKV LQNVERKHMD LPEWKRHIAA GKSFGKPQGS
MTILEQRQSL PIYKLRSELV KAVSENQILI VIGETGSGKT TQITQYLAEE GFTFSGKIAC
TQPRRVAAMS VARRVAEEYG CRLGQQVGYT IRFEDCTSPD TNIKYMTDGM LLRECLLDPD
LNAYSVIMLD EAHERTIHTD VLFGLCKQAV KNRGADQLKL IVTSATLDAV KFSQYFNEAP
IFTIPGRTFP VEVLYTREPE TDYLDASLIT VMQIHLTEPP GDILVFLTGQ EEIDTACEVL
YERMKSLGPD VPELIILPVY SALPSEMQTR IFESAPPGSR KVVIATNIAE TSLTIDGIYY
VVDPGFVKQK IYNPKTGMDS LVVTPISQAQ AKQRSGRAGR TGPGKCYRLY TERAYRDEML
PTPVPEIQRT NLASTLLQLK AMGINNLIDF DFMDPPPVEA MVMALEQLHS LSALDDEGLL
TRVGRRMAEF PLEPSLAKLL IMSVHLGCSE EVLTIVSMIS VQNVFYRPKP VRSTDTLWSI
FVDLFPTPRR PVYSFHIPVF SIVLAENYSM TMMNGHSSLE LAGCCLLTTA GHHNYQSWEC
YLFFLSLQDE EKDKQDVADQ KKSKFHQPEG DHLTLLAVYN SWKNHRYSHS WCYENFVQIR
TLKRAQDIRK QLLGIMDRHR LDMISCGKNM QKVQKAICSG FFRNAAKKDP QEGYRTLVDS
QTVYIHPSSS LFHNQPEWVV YHELVMTTKE YMREVCAIEP KWLVEFAPAF FRFGDPTKLS
KFKKGQKIEP LFNKYEDVNA WRISKVKKKI YNPNR
//
