ID   A0A0V1BMW3_TRISP        Unreviewed;      1466 AA.
AC   A0A0V1BMW3;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Derlin-2 {ECO:0000313|EMBL:KRY38484.1};
GN   Name=DERL2 {ECO:0000313|EMBL:KRY38484.1};
GN   ORFNames=T01_7263 {ECO:0000313|EMBL:KRY38484.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY38484.1, ECO:0000313|Proteomes:UP000054776};
RN   [1] {ECO:0000313|EMBL:KRY38484.1, ECO:0000313|Proteomes:UP000054776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS3 {ECO:0000313|EMBL:KRY38484.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the derlin family.
CC       {ECO:0000256|ARBA:ARBA00008917}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY38484.1}.
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DR   EMBL; JYDH01000025; KRY38484.1; -; Genomic_DNA.
DR   STRING; 6334.A0A0V1BMW3; -.
DR   eggNOG; KOG0858; Eukaryota.
DR   eggNOG; KOG1499; Eukaryota.
DR   InParanoid; A0A0V1BMW3; -.
DR   Proteomes; UP000054776; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006950; P:response to stress; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR007599; DER1.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11009; DER1-LIKE PROTEIN, DERLIN; 1.
DR   PANTHER; PTHR11009:SF32; DERLIN; 1.
DR   Pfam; PF04511; DER1; 1.
DR   Pfam; PF06325; PrmA; 1.
DR   SUPFAM; SSF144091; Rhomboid-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        55..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          1192..1289
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1317..1351
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1466 AA;  168918 MW;  B157A1B6D0A32609 CRC64;
     MALELALREY MDIPVVTRVY ITACVVTTLA VQLDIVAPFD LYFNPWLIIS KFQVWRILTC
     FCFFGTVGFS FFFNMLFTFR YCRMLEENFY AYRTADFLAL FLYGGTLMLI MGCFVHLLFL
     GQALTIMLVY IWSRRNPHVR LNFFGLITFN APYLPWVLFT FSVILGSSFM VDFVGIACGH
     FYYFMEDVFP YQPGGFKVLI TPRFLKRLFD RREDIDYRPL PGVVQPGFNL KNFDRMETFS
     LAKARKYQEA GNYGASIANY FYILKKEPHL DNAIQREFFT CFTSFVQQLE SRGMYRDIME
     YFEMAEQCFP RSSKLCKQLG EFLLRHEFYV ESAGWLLRAL RMEPNSAEIR HLLGSTGGHL
     FERWHFRMLN DFQRNQAYCK AIQSVVCSDH GPVNSMLDLG CGTAIWSMVA AQAGVERIHA
     CDSNVVMYHI AKETLKRNGF QDRVQVTHAH SSELDLPEPV DLVVCELMDA GFYGEGIVET
     LYNCFDKSLV NNSVDRQCLI PKGAVIYGAL VECEEIRRSH VIEGKEKFGL VANLNFEVRS
     NCASFMPPAS EEIFQAVEPY DSVMMRKVKG GYRMLTETFV VDQIDLTDVG QLKARLDGQE
     QLIEVRCIQS GKLDAIVCWF RAELTDGIYI DTGPENCTSW EQAIFPVSLD LQCNNNWCEL
     DQKVLISCQV KGNELRCRVL QAAEEYRYQI EIIPTSKLSM LNDLALLRSY CNSFSKLTND
     TNLALFDMSH NPLITTAACK LTNMDVWCRA DAPPDWDTFF AKVVACNAEQ QCRIHFLGRD
     SATNGGMVKF ERLICMPVET SGVLAPDVLE TILYNRLTLE IDHVLPEQLR VLAMLVSSEE
     LSEYCRVLDD TRTLGFFIAD QVNAFQSDHF EDVEPSTLFK TELTERFELF GLDLQQSLDP
     ENYNLPAMCE QTVTKQVRIK RDGKLNAVFY WFRGDCPSID CLLFDTSDEN GHFRLAGCLV
     EPRPVSRGEM LTIRGTLERK MNELKNQASQ QCKERAASIL DKGDQSGGTV NGKKDGDSAP
     SCMLDVVEEN LSEDSFEWNF ISERYAGLVR EKFDSVLDIV QRYCQISNFQ EQQQTVDFAW
     LEALSVRDLR MLVESETTKR IASERTVEQL QQRLRIMQDK LISMETFISV DLKSLIEQIV
     KLVDSMCREL TTNESKRSTW ARGMQERLVE AVEYSKLCEQ SIEVNGEQIA GLQILRERLQ
     QSEQQLKVDL ENQERTVAQL NRQKSEFCSQ IEALKLENEQ LKHWRQKGEK FRLQLRDKKL
     EVESLNECLK KLKVQLIEAK KEEKNLAMQL SRAAQIQMNQ KYDEFQRRKA EEIHNLQLKW
     KSEMEELEKT NRRLTEERDQ AIERMVELDN LFKAKRSGIS AELQKRLMEK FQQILNDVTS
     ITDADNFHCP EKMSSRFQPL ITSSPVKGTN SLTEEFFEKM IHLQLIKTPR YTAAAAGNND
     TKSYGNDFVV ALNSNDNSPS RAAGEE
//