ID A0A0V1BS04_TRISP Unreviewed; 1555 AA.
AC A0A0V1BS04;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tight junction protein ZO-1 {ECO:0000313|EMBL:KRY39633.1};
GN Name=TJP1 {ECO:0000313|EMBL:KRY39633.1};
GN ORFNames=T01_5153 {ECO:0000313|EMBL:KRY39633.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY39633.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY39633.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY39633.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY39633.1}.
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DR EMBL; JYDH01000017; KRY39633.1; -; Genomic_DNA.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 79..166
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 178..256
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 418..497
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 700..802
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 1415..1533
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1212
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1555 AA; 170330 MW; 6857BCF53AA83F98 CRC64;
MASSPSDVIS GLGENRPDGT AAIELHKENS KDRPPSTSNA ELIRSCSYEV PMGKNSSNEI
LVEPVDEEDC DHTTWIYHSV NLTKVQGYGF GIAVSGGRDN PHFKSGDPSI AISDVLRSGP
AWGLLQINDR IVYVNGVNLE NADHSTAIQI MKDSENLNVI VKRRIPFPVL EYDQRTLKFT
LTKSRRKDDF GIVLGCKFFI KDIANRRLAE KDPGLKEGDV VLKINGENCD QMTLSEARRL
LDRSKDRLSL VIQRDVPRGA NWKWSSQATL YERIGGTDTP RQSPTPRHSP MVYVRNADHD
ASSARSHFPS RYHDRFSRPP SEDRTVSPKR QSTCSQQSFG SRGPPQNQYF YDDGGSNVFT
CQSPSRTISP SCESSHASVN CATMDQQLLA PHQKPPLPST MQVLFHCHLL LVTNEPRLIT
FRKESGSVGV RVIGGNEVGI FVSAVQSDSP AAVRGVRPGD KILRVNNKSM LGVTREEAVL
HLLGLQDHVE LFLQYKKDEY ERIRSQNIGD NFFIRSGLIV THFTYEKPEN GELSFKKGDI
FQVIDTLYGG TVGSWQAICV SSPSMSSTRS DYVHPKGVIP NSSRAEQLAH AERSQSQSQA
TAEMKSSTLL RRKVTMSRRS KSLTKSHWDE VVFSHGTVHF AAYERVQLRH PGFLRPVVIY
GSLADVAREK LLRDFPLAFL SSQVENGNDD SDPGKTNRIV RLNAIRDVMN KNKHCILDIT
PSSVEKLIYA QYCPIVIFVN VGSRTRLRDM RKRLAKTSAV KSSKKLFDQS QKIQKLYSHL
FTAVIDATHE EKWFEVLRDL IAHLQSRRVW MSESKPSELL DDDFLFPMSN GRYGSVGGGD
SDVDSLADES RCDLTSKRDA TVALTTVDAA SRMDVPYADN SSSSSYAMAS GTLRSPTKTH
AHMCDRQSSG SNVDMIASMY ENRDNIVALM ATMRRKPPPL ARKPKPPPPP RIGSSNASLT
SDVQCTVDLA AASADLPRIA ESAVSVSPSA ACNGSTTLMQ TSFSPATHVD NSRLLTKIDE
REFVPYSPRY GRPVADCGLY NVKQILEGTM DNYDSGVSAP TASSRLMHSS SSALGHPVTG
GKPNLTESMS LSYYDNTERA RLDYSASLGL NSHGAAWQNY EHPSSYASAH SNSQFQHFFD
GHRVCPVSPT SSGSMAAAMR SVNGIYGSRS SHDSYAQHVS EGYLLAGSAG SKRPPLVPHR
SPVPPPAPRS TYTPSTPRHS QSMPPSMSSC GSRVLTSEDE DQQQQQQHQH HQFGRISSPS
LGNRSQPQPI PLARSSLTKA HTTTPSAAAA RMSDPSSVHL PKSDAGAAVS SEMQAIGVNR
TAAVRCDEAL DMSSGEAVKS RNSSDDDGNE FETPQACTKQ QAVVIGGGDD NDDDDSGGQP
VSDVSGSKKK QQCGSSEENG LGTVASDADL FICRSSASAT VDHTGATLQL QDPGVRLIIP
QAALSSPVEM FVQLMTRELE PRTSNGAFPS EEASSFKEKS RFVIVAGPSG LKFSVPVELC
LPKSALNDGK QWFLAFKSKN TDHFGQRRCL NLLDSCAFPK KNVDPDQVAF FISNF
//
