ID A0A0V1BT31_TRISP Unreviewed; 2147 AA.
AC A0A0V1BT31;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Dedicator of cytokinesis protein 1 {ECO:0000313|EMBL:KRY40095.1};
DE Flags: Fragment;
GN Name=DOCK1 {ECO:0000313|EMBL:KRY40095.1};
GN ORFNames=T01_2419 {ECO:0000313|EMBL:KRY40095.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY40095.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY40095.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY40095.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC family. {ECO:0000256|ARBA:ARBA00007091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY40095.1}.
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DR EMBL; JYDH01000014; KRY40095.1; -; Genomic_DNA.
DR STRING; 6334.A0A0V1BT31; -.
DR InParanoid; A0A0V1BT31; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00866; PEBP_euk; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 3.90.280.10; PEBP-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR035810; PEBP_euk.
DR InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; PEBP-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS01220; PBP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 198..260
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 670..848
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1479..1902
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1979..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1982..2004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2005..2055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2109..2127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY40095.1"
SQ SEQUENCE 2147 AA; 245748 MW; 4D8151B3960ADA34 CRC64;
LSLNRHFSRS ILSKFCNSSM SSLKDKFEEH KIIPDVVDQA PTQHLQVKYK SGVQADLGNV
LTPTQVKEPP SLNWVATPGA LYTMVMTDPD APSRQNPKFR EWHHWLVANI PGCEINKGEV
LSDYIGSGPP QGTGLHRYVF LVYQQKSHLT DKEHGHLTNR SGNNRGGFSI RKFAAKHDLG
APIAGNFYQA EWDDYVPKLY EQLSAKHNFR PNVVGNYLPL LIGDVVRVLQ FSGEWYYGCL
DDDMTKAGVF PISFVEEKHA NFENNELGSI AQTAVYSVLT VLKEWKKMCR ESFERRGSID
IEKIFPMMKD IINWRSQIVS KKLSLEEVKK LNYKIALKID LGNKMLGADV IVRDIHGNEL
QTENCSVAEL HKHHLETAER IATEIEQSSW NTLSHLQRHS SRAEKFMQTK RSQSNWNLLL
TFVEFHHPYM NNGELSFMLF DGRLWHGISE PAVVVVQQNN STRFGVDPAP LQRFIITVRM
RIFIIVVVVD LQVGNLCFVV QDLGTKDLDR EKFWIIFLAT KTGPFEWKDT LTYRKTHVSS
TTVRQTFAVA ALDLTELLNQ AFCTDPDAGT GAGAGAFSST IDEQEERRIF LPLRPLVDDS
VEGMLRKIVD NKIGYNSELE TKGDGFWLTL QPMFASLDEL KHSQPHLFSN PFKLVRKMGF
PEVISRDDVR NDLFVTLVSG DFTHCTGRSD KNIEVKVCLV DELTNSVLPD SVVNVGVAKE
TFYTSSVFYH QDRPKWFETI KVNIFNLEKI FCTLLSKDRN DRPFSVSFIR LKQSNGTVIK
DGFHDLVVYR VSSKIEENDF SYHTLPASKA DLEMSGMEGT SSKFHIQSPT GGFAISPKDF
FTICTTVCST SLTQNVDLLG LLEWETKRVN LKSSLEALMK DEGDRAGEEI VKASLLHVGV
FLQDILDVLF TVLISCNDHD QLVFDALVYV IGLVGERRYH NFKAVLDSYL LLHFSAALAY
QKLIPIFKDY IDKVEECSNK LLKTLKSLEY LMKFIVRSRN LYVQLKGSNA GKERFHELIC
SLFISLTTLM LYQTDWSLLC QGAALKYIPH IVVDVLAVFD ARELAAMMAN FLKNVPRDRL
TKQKLMCLQD LVHSELIKKS EPRAVLLPVI LESVRNQIDD NEELELCAQI LTEIMNVLFD
KHSTSGAHSS TLLFIMRTIL RQVVQVVVRL IEAGENLILG QYVALLLAIL EELDACTYRC
YIAEFATRTD LMDFLTELLM LFKDLIRRPV FSSDWFQMIF VQNSIMLKIL CYAASTVKAR
FLHEKFEFQV CNSFFQTVVT FITQKLLQLE QYNVKKRKAI LERFRDMRLT CARELVRSMW
FSMNLLEKNQ FIPSLVGFVL EVTLIPVEEV RKLTIPIFFD MMVTEFYLRA NNNSATTSTP
LLGNFSYNSS VMEFETEFIK KLDSLVENDY GDAKYVDTFV KIMMQLCSSH TEALRDEGIR
FTKTVEHLMF RLLEFRNVRL YHNNVNNCMS CTVSLLNFYY EIGHTELYIR YLYKLYELHM
QRDNFVEAGL TMALHAECLK WCDSSVHALL AHSLFPDCVS QRELKEKLFL KMIDLFDRGE
LWEKAIVVCQ ELQHEYEHRT YEYDKLANLL EKMSKMYRNI LKHQRAEPEY FRVLFCGLGF
PIFLQNTTFI YRGDGYERLA DFTGRIQAQY PNATLLQTLQ PPGEEIKRSN GQYLLINKVD
PIYDDQIKTI PTPVKDSRIL WYYKCNDVQK FYFSRRISKK DCTLSKEWPV ADEQENEFGL
MWLEKTILVT SCRFPGILRW FLVSSESQVE LSPLEVAVDS MKATISDLEK LIEEVERYSE
RALKPLAAKL QGMLQPAVMG GIKNYEKVFF TEEFMSKGSR KNLEVLELLK EQIASQVPLL
EKGIFLHAKF CSSDQREFHH LLIDCFKEYK SHVEQHYGKQ ASLLPENSSL EIPKSNVLVY
KQNLIDGSAT SNDGRYPFSS SIASRKSNSV REWQASTSAP WLLRTGVMTT LSGATVPRRI
NSKEAAIRRK AAHSTEKEIH QKRHSNSSMG STQSAEMSCA GSTIVLTEKL TTLRPPRPDS
SFSKGSFKQQ SNSSINRLTS SVEKLSISAS HSLVHSDSDE ILLTNDRIDD HAAVPPPLPP
RRDSGQIEIP DFNASSVTFS PLSPQRLPSI ISGPRREKPL PPLPTTE
//
