ID   A0A0V1BV30_TRISP        Unreviewed;      1266 AA.
AC   A0A0V1BV30;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Rho guanine nucleotide exchange factor 2 {ECO:0000313|EMBL:KRY40626.1};
GN   Name=Arhgef2 {ECO:0000313|EMBL:KRY40626.1};
GN   ORFNames=T01_1306 {ECO:0000313|EMBL:KRY40626.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY40626.1, ECO:0000313|Proteomes:UP000054776};
RN   [1] {ECO:0000313|EMBL:KRY40626.1, ECO:0000313|Proteomes:UP000054776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS3 {ECO:0000313|EMBL:KRY40626.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY40626.1}.
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DR   EMBL; JYDH01000012; KRY40626.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1BV30; -.
DR   Proteomes; UP000054776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR13944; AGAP007712-PA; 1.
DR   PANTHER; PTHR13944:SF21; CYSTS, ISOFORM C; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        199..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          444..619
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          145..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1131..1164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1239..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          992..1052
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1241..1266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1266 AA;  140972 MW;  F0DA2B36E25C69F3 CRC64;
     MKRDVSVSWP NLAEISSRTP STSFSICCLI KSHSLTASSQ SVEACQLSFA DNGVDLAATA
     SHGVHKHFAD GSRRSCSGDD GTPMKLAVDR GAPVKLSKSV ECVGPGTVRV NLGCSKSEVD
     LSQLSAASRL SEKRFSLGDQ SSLAQRLHDS SNEEDPAGTT ALTANPADQQ KELLKFVDNA
     VHLDRSFSST PSIDVDSSLA YFAVLPRGIC CICAYLVTLL VNFLFVFFRQ TQRSIQRTTA
     TNSSLIDGGA SNYTSSATDG LTSESCWQSF ERQSDWFIFK NVQLLWVSFI GTVSSVFGMI
     RCASVHNFRV DLKSIEKVLK LRSSKKHAKV KEKKQHVWLQ CQEKAGLNCD ICNKAEGNYS
     FVRCTDSSSS VIGQIYAETS NRSGPLPQSA DCVISVLPDG AGVYTIPDEK WAELGLWSAE
     ADGNWWSTGR GKVARNYMST KEVKRQDIIH ELVTTERHHC ITLVLLKHTY FDGLLGLNIL
     TNDELNMLMP HLELLLEVHL HFLQLLKKKV DESFTGGVAE KMQLAYTTFC SRKDFSVQEY
     HRLCQASPNF SIFMENMNKL PYFKARSLPD CLLLVTQRLS KYHSFVESLR KNTEDALLKD
     EILKAEQAVK KLVANVDQGI GDIQLQQLCK EIVAQMDTKE STTFLGKTFT KNELLSNTRT
     LLHAGDVYWQ NAMRKPTEVK MLLFSDIIVF LQRVGNSYAF FSQDNKECII SLLKLIVREK
     AGRSGSQGLY LISAAPSHAE MYEIICHTKK MLASWTERIQ RAVDVCPPAA IEERPSSESV
     FAVEHEEQLK TLFGKVNSCN DELKKLLDCQ IEAYGEILQL VHKMNIPDEE ERMKIMKTID
     ECLPAKIAAT AVARFADLMS QLVRERCKQQ LLNLACPADT ATAQTTTSSD GSNINRSQTF
     HGMRNDSKKS IFKTDALFIV SCVICYLKVG FFETFLHLLH IFLELYRKRV TVSGIPQRCE
     ENRIVETAID NGMSGEIHAD SKSAFCAVMS RLKDAEIELD GMKHEKAMLL IELEKEKSIR
     SSSAQNVYNA GLEELRRLHS DFEKRRSEFQ QLVDEKKSDF EHRENAIREK EERLNREDSE
     LQSKWQCLRE AWEKLQLSGV PIRSLTSPLA PSTSCAAYIA TCNSSTNASN PVNHPAAGGD
     NSNNSGPIGK QSNSTVANST PTVGVDDSSN ITCVRSGVGI SGGSTSASAE KQSFRKVQVP
     PYLLGSFVHS GRLPDDLVRQ QLPSKLLKDD MFNSLSSRFQ SSMKERRKGS PKVKDNHSIN
     VKGKQK
//