ID A0A0V1CTW6_TRIBR Unreviewed; 2509 AA.
AC A0A0V1CTW6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN Name=Mtor {ECO:0000313|EMBL:KRY52731.1};
GN ORFNames=T03_11326 {ECO:0000313|EMBL:KRY52731.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY52731.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY52731.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY52731.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY52731.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDI01000099; KRY52731.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051247; P:positive regulation of protein metabolic process; IEA:UniProt.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1417..1980
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2131..2448
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2477..2509
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2509 AA; 287583 MW; 846FB56F99353AE2 CRC64;
MLLTTSTKKS KTRPIAHQIR PPPISAICFR TSVLCHRSSG SNVAATVAQI TENDAEYINS
FFCIKMTAPA EYFLQRLCTK DEFARIQAAY DLYWYVKCEL TEVPQEVANA FREKFDFIIP
ELLTSNISGE RSAAIYAIAC LAQGDASFSN VAPTNLRQTN PAGVASIRFH RYTHYLRNIL
PSSDANLVQL AVRAGAHLAL RLSNLYTTEY VYFELKRATE WLQSASTDRT DNRLSAVIVM
KELAYIAPTF FYQHTPHFFD CIFEALMDGK VQIRERAAEA IRAALVVTTQ RETKLEQKIH
WHKQCYNEAN RFFEEARSSH ANVREDRVHG GLLVLNELLR NANSRWERII QELAESNISR
SAILAHSQEL PKDFDFKERF TDLQEDVIAP LVSPSYFMNY ESRNCRLKIA EEFNEICSNV
TWCCSSTKAS YNVQLQLALL CRLAAFDPQK FLAINFDDAV NYLWSCMTRE KLRPDCLVAI
GLFFMALKEE MVPYLPKVFD FLNSCLPTKE SLNLKKRPVV VDTELFTCVT LIVRAVGSPL
ESFLKPMIEP MVLTGLSPNL KLACYEITTK IPSLKKIIEQ GLLEQIYSVL LQQKMPNLLT
LLQPIEPPTK PVVVTDPHIT SLALTILGTF PFQRFSLESF LRFIPEGYFA NECYEIRLEA
VRCCCQILLP FVSTLTPEQS AAHNVSLLQM VNEVIKKFLD RRIRLMAFQC LTDSNAFCLH
LAQDEVLKLI MMGLQDEDCS VREKIIHLLG KLTNVNPAYC VPALRRILMQ IIEEMSLSGL
SRNEEQSARL FSCLVRCAPN FVKPYAKTAF EVLLPKLKDS DTNGDVVVSF LRALGDLVEL
MPDKIEGYLD ALLPVLIQLA QDTVSAGKRK AILIEYFTNA SMWALSKVIE CTGFAVEPHK
RYQDLLDLLL RTLKSEQSPD IRRETIRLIG FIGALDPYKQ KALHTAVDLA SNCTGLALSL
PHIKDITDRR LEILQWFHWE RCSLEQFYPT FAIINLMSIL SDSTYNQQLL TAAVHSLVFI
YYSLNDKGLT ALDQVFPTLV NIIRNSDPSM REFLFQQLGY LVSVVKHHVR PFLDDIFSLI
RDFWTTKTQM RLTIILLVEQ LAAALGSQFK PYAASIIPSM LRIFLHDTSV GRSVTSKLLD
AFKKTSFILE DHFHLLLPPI LSLAENVEVP IDVRRSAIET IDVFGETTSL SNFACRTVQT
MVRVIDSEPE LRFAAMDLFC TLILHLGEDF LPFCRVIDPC LERNDVVHER YISLILKTME
IGKINPTEEK FYKAMVRGRR CLLAKQQQVM QIEVRKVVCN VEQLRKIWLT NRCVSKEDWI
AWLKRFSIQL LKESPVPALR SCYSVAVNHY QLASDLFNSA FASCWPELNE TYQDELIETL
QLALSASECP EIIQAILNLA EFIDHTEKGP LPIDPKLLGE KALETRAFAK ALRCKEAEFY
NEVTPEVLES LISINNMLQL RESSIGIVEI VRKRGIKVKD TERWYEKLND WDKALEAYEA
KQNQFPDDME LTLGRMRCLE ALGNWSKVNE IVEKKWQSST VEYKEKMAHI ATCSAWGLGK
WEAMQDYIAE ISQSTVEGCF YRAVLAVHHQ NFCEAQFRID QARDLLDNEL TAMLSESYSR
AYDSIVMVQM LSELEETIDA KRNPEKRRIV PSVWWNRLQG CQRSVEDWQR ILQVRSLVLT
PDEMRQMLLK FASLCRKSGK LAVSRRTILT LMDCDPDSCA PIKLPFERPE VCYAYCKQLN
CEGRRDLALS QLQLLLEYGF KKPATLPAEL LSLKARCFLK LGQWSEQNLI NEDSPNVEVM
QHYMYATELD SKAYKPWNAL ACANFNALLY YRQRAPIPLI QCQNDSGDSP LKPLNPNLLV
PGTVPDDSVI TMYAVQAVKC FCRAVMLCHG NSLQDTLRQA FIQLLTLWFD YGHIPEVYDT
LISRIKTVRV ETWLQVIPQL IARIDTPRHF VSHLIIEILM DIGKNHPQAL IYPLTVASKS
SSSARRQAAD RVLKHMSDHS PNLVQQASMV SDELVRVAIL WHELWHEALE EASRLFFSDR
NVKGMLDLLN PLHALIERGA TTMKEQSFNQ AYYRDLKEAQ ELCIKFRQRG NLRDVTQAWD
LYYNVFRRIT KQLPLLSALD LQYVSPKLLK CKNLELAVPG TYDPSRPLVC IQSVQRRSDG
QEYWFLLKGH EDTRQDERVM QLFGLVNTIL LQNPTTCRLN LTIQRYSVIP LSPNSGLIGW
VPNCDTLHAL LRDYREKKKI LLNLEHRIMQ RVAPDYDHLP LMQKVEVFEF ALEHTPGDDL
QKILWLKSPN SEVWFDRRTN YTRSLATMSM VGYILGLGDR HPSNLMLERM SGKIVHIDFG
DCFEVAINRE KFPEKIPFRL TRMLINAMEV TGVEGNFRLT CEKVMSTLRA NRESIMAVLE
AFVYDPLFSW KLIEREQFER KTKNVSLSDD DAISLLSGGP GFQPSEFVSR KALDIIQRIR
DKLTGRDFSS ACPTTSKSLT VQAQVDLLIQ QALSHENLCQ CYIGWCPFW
//
