ID A0A0V1D047_TRIBR Unreviewed; 1162 AA.
AC A0A0V1D047;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Tubulin-specific chaperone E {ECO:0000256|ARBA:ARBA00015004};
DE AltName: Full=Tubulin-folding cofactor E {ECO:0000256|ARBA:ARBA00030180};
GN Name=SLC17A5 {ECO:0000313|EMBL:KRY54387.1};
GN ORFNames=T03_4874 {ECO:0000313|EMBL:KRY54387.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY54387.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY54387.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY54387.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TBCE family.
CC {ECO:0000256|ARBA:ARBA00006286}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY54387.1}.
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DR EMBL; JYDI01000071; KRY54387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1D047; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17044; Ubl_TBCE; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR044079; Ubl_TBCE.
DR PANTHER; PTHR11662:SF331; MFS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF14580; LRR_9; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 993..1012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1087..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..88
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1117..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 129907 MW; 27FC60A1A1118ED6 CRC64;
MLSVLIFFRD FLMDNYMRRN KIPEMVIGCR VRHRGARGVV KFCGRIGSLD GEWLGIEWDE
KSRGKHDGTY QNVRYFETSA PQSGSFMRPN TVEYGCSFVE AGKERIIECT NVSQWEKIES
FGSAKVDASD KVRKEMSCLC LDGTLVSFAG ELSVSDSVLF SGITSLYLRN TLIVDWSEIV
KIISFMPRLS SLALSNNKLQ STHCAALENV TFSQIETLAL SQTEYNWNEV SVLPKVFPNL
NEFWLSYNCI DIIESELKMP SLRLLSLESN PLASWHEVLK LGSLSNLQCL FLGHTKLKEI
CIPQSGLFPS LRSLMLSHNE ISDVGWNSIN ELNKIPSLEE LSIIGNPVLN LDKSRSRQFV
IAKIAHLRVF NKVAISAAER KGSEIDYLKN YGTTWLKLRN AKGMEDNLAC FLSEHPRFMD
LVKLYGEPDH FETVKNPLKN MTQCMQMLKF TYSDKPPVEK RVPNFLTVQK LKILVGELFH
LKPQLVKLSY KSSRNPDIVV SLDHDLYSLS YYSVEENDII IVEQICSSSL GRELLALPNL
RCQFTWSIAI YIQNPLSSSA ALHAAMMLHI ILHPKHDRSR GSCSDAFVLR LFCNDNARGR
AHSWRYTRQL SRVSDVVPLN DFFHIHPVEL NSMESELYSC KRCKFVHFLR SIRFQICLLL
FGCMFCLMFA NLTMSVAILS MVNTTLSACV FIAHNSTSSG CDRADHIAGI GDYVHSEGSV
NWSPETQGLV LSAISWGRLL SPLVSSIVAR SDVSLWLPAS LIVSALASSL IPVSVSAGYV
MIVLLRFLLG VADAVAQPAI NHLLANHFSS KTRNNAYGWT SAGRQFGVLA VYPIASIVSD
YSGTKEGWPF VFYISSAICV VWVLLWVFFL LMHRRNLNRK RESISSVSSL SSIKSMISRM
DENTQRICWK KVLQSSRFWC NMMAILCHEI PLNTAMMFLP MYMRDALHFC LKTNGVLSTL
PIISFMVTKI LATQLDHAIK SACKPDATKT AKWFNLVASL GMGSFLLGVS VLNCRNRGLA
VILLCCGVGF AGFHTPGCIG TLLSLAPAHS SAISSMAYVL ISCTSMLIPL VVKAIVVQSS
SREWQTVWQI CAGIALLPIT FFSLHGTADE QAWSKPIRDQ VEKESPFPSS PSTSSSSNSL
SSKMTASSSH CHQLPMMTVE KL
//
