ID A0A0V1D1V4_TRIBR Unreviewed; 1684 AA.
AC A0A0V1D1V4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Voltage-dependent calcium channel unc-36 {ECO:0000313|EMBL:KRY55465.1};
DE Flags: Fragment;
GN Name=unc-36 {ECO:0000313|EMBL:KRY55465.1};
GN ORFNames=T03_13056 {ECO:0000313|EMBL:KRY55465.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY55465.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY55465.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY55465.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY55465.1}.
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DR EMBL; JYDI01000054; KRY55465.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1684
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006876346"
FT TRANSMEM 1161..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1207..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 248..433
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1315..1367
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT NON_TER 1684
FT /evidence="ECO:0000313|EMBL:KRY55465.1"
SQ SEQUENCE 1684 AA; 193662 MW; 097F44420F5AC1A7 CRC64;
MTETSFAGLF FQLFALAAEL HAQDLRGRGA IPISASIVEQ WAKSFGLDLY STATTATQAE
ELEQKYQEKN ARVEYFDPEE VIDVMKARLE KFLGRRRQLA EILKENLENS YSLFQMVDRE
AINDLQSDDF SCLNRHYVDP LLINSSLSVN YIPNPNFFNL PVNTEKSAIH VPTPVYARDP
ELLSEIIWTE SLDDIFKARR AREFFAASWQ YFCSQKGFMR FYPASPWFYD DSHTCLDMYI
DAATHAKNII IMLDMSGSML GQRFEIAKQT IEMILETLTE NDFFNMIVFS EEPKFILSCF
RNRLVQATIK NKKLMRVTLD NVTAEGIANY PAALSLAFEV LIEASQNPGV NSGCQNAIML
ITDGPSDTYE DIFEKYNKDK TIRFFTYLIG DDVTETREVR WMACYNRGYF AHISNLADVQ
EKVQSYIGVM SRLTSERNRT DPVWTGAYYD RLGAVLVATV AFPVVANDSF RGVVGASALI
TELQQMAPLY MLGTHSYTFI VDNNGYVVHH PQLRPLYMGK AKPHYNSMDI MEMEVLADNY
LENGSLANPV DYDSDLRRHL ADGVSSKDFL RKFSQKIIWA CDGPNNLRRV YLQNNVYHYR
GINNTLMSLA LAVPEDSRYR IALPSTYSPY PYKNIDFKWF SGTNWRLHPD WHYCRINDSD
YSMTKEEAFV INMKHYSETG RIARNCALYT YLIERLLFDA EVTSQMDSAW IQESRLDERK
GVHLVYLATH AGLTRFVSMD LKDVQYQPDV QTWPSDDNRT EELPSTLDKP YFHFSKRHTR
ALDEVFYKRA MQFLNGEFVF DVNITNNIYL KNGSQTYPHA KDGRSIIVTG NRAILVRDDY
GNEAPASVVG FEMLYASFEE MIYNASHKMC HFNSKVRCYL LDEHGYIVYA SLPHTSQERV
HYLRQFFGHL SLENTENGAI ERYLMKKLVD LFVYQKLLYV DFQDLCQNLN LYNSARPIVS
RFKIDHLNAA ENDQVVCWKF SSKTYCFAYL KMTFRFFLEI NPLAIIFSLF SRYTATFRDI
QDGLPCDRAS SFYLLNNDFK GPLTLAEGKQ LCSSVATSDS YARVSSCNLY AYAVRIEKTN
LVLVVYSTEG TQCNGDLCKD YFSRDSLPWG FNIALNATDK VMHPQACKLT TRYRRPPSAC
QAVEDDDPFA HCSGCSSQAT LSLVLLCTAV LFVFVSDVSF VIIGVIDFCT YVDFLNANLH
TDLTANVFLN LYLLYLLLIL MILTQLMEPE LESVPSAEVA PSDRFWTTVL TTLGGVSVEE
LTSAIAKCKD LVLQTAPMSA IRRELVRRLI ELRQKLHELK DGLAQDSKFD AAVMGHQFKT
PSRTILERRY CEFCGGLIWA FLQPWYFCRL CGFYVHVKCV NKVKRQCASL IVNENPVFEL
EICPERGLAM QNFQCADCKT QVSIDSSLMV EASQTARLCH YSGFYFCSVC HWNDEMVIPA
RVSRSTRQFL RLMQKRPILR LEAMNPCLFK NIPQLQKIKS LRGRLLLMKP YVMYCREAAS
QCLITHLRPY AHFMETLDVY SIRDLIDINE TVLEPRLMQA LEIFEKHIKN ECSICQGNGY
VCELCDNSEI LFPFDRSIGK CGQCSWIYHK SCFDKNNGIC SRCLRMSSRM AIRLLSKDSN
TRPTIIVCTF EEMQSVISFH FISFHCFVEL DLQLRCTIFG KEGRISSTNG HMVESSIKER
RSNN
//
