ID   A0A0V1D359_TRIBR        Unreviewed;      1115 AA.
AC   A0A0V1D359;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Pleckstrin homology domain-containing family H member 2 {ECO:0000313|EMBL:KRY55978.1};
GN   Name=PLEKHH2 {ECO:0000313|EMBL:KRY55978.1};
GN   ORFNames=T03_1579 {ECO:0000313|EMBL:KRY55978.1};
OS   Trichinella britovi (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY55978.1, ECO:0000313|Proteomes:UP000054653};
RN   [1] {ECO:0000313|EMBL:KRY55978.1, ECO:0000313|Proteomes:UP000054653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS120 {ECO:0000313|EMBL:KRY55978.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY55978.1}.
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DR   EMBL; JYDI01000048; KRY55978.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1D359; -.
DR   Proteomes; UP000054653; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17094; FERM_F1_Max1_like; 1.
DR   CDD; cd00821; PH; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22903:SF8; MAX-1A; 1.
DR   PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054653}.
FT   DOMAIN          358..467
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          480..586
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          614..772
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          783..1096
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   1115 AA;  127374 MW;  27E611ED279A526A CRC64;
     MQHSMESSNC SVEEKRIKIK EWVKSRLEEL DQQNQRIRTQ NILCANRLEL LYTCAKNNLH
     WRNCLMTASA EGTRMLDLQN HMNNNINNNN NNSCLDGSIN GSSIDRKEWN NTLDTDEHSR
     TTSVERSNNI ANEFIDSTNC GKGTASPLLS CRKRVQVIQT KQQKQNDRPV PLPRATVQAR
     AALDRVSFMR DSLEMALTAE EEQNDEELAT AHHRHIENEV LKLAKSCFLP DDDISVKTLS
     TVIDMPNTNK TASTKIRGSV KRRSPYINVP LYLVCTDREH MYCRRASGSS ESSSQMSNRD
     TFADSAAIDC RGSVSHSRSS AKLSFQQRQV QACADSDDDY SVPPDAASLP ESMSLRCNIE
     KQGYLHKVRD PGKPSKRRWF VLRDDILHCY RSSESCQHGR EKLWEIPIAN VISIARVAYM
     PENGFEVKFL QHLSYRIIAT HDKRVCLVAS DGKTSLDWFK ALQKCRKTLT MRKCQEPNEN
     ATCRGWITKV HYGRSKRFWC ALCNDSLLFF KRPTAKVPLS HLCLEKCTIR EAPCSSADES
     DGEEISRQGQ QHSLEVRTVN NDLIYLIFLS GEDKERWFYH LTIAASGGPQ QAGSAFEQLI
     NQLMKVDGQA DSQLWKDPLI STCVERPTSP MTRITDETDR KTAFNLYKSA YLFSSVQTRG
     GAEEYHLDLA QNALRLALAN PTIRDEFYAL LIKLTNSEQI SHQAWRLLAM CLSLFLPSYP
     IMWLMKKYLR NACLNGEPSH RLAAFCQRAL ERTVSNGART EAPSKLEIMA FLTRDPCEHS
     LPHSIPVNMP DGSYQVIGFD GSSTVIECSQ RLCQIIGIRP PPQSGYGIFA DDPRMPDTLQ
     YLNPNEKLCD VLSRWERQLK EHTAGKVPNR RAIQLLFRRR FYWPNFARDE TDQERVFLAY
     QLADDLREDH VPVSVDLAVE LCALMAQLHY GSYKSTNDNR TDNIIRRTLS EKLISVACRN
     SLKQRVEDKW KNFESFTTTE AASVIVQTLR LWPYFGASFF EATIKGKADE SLWLAVDSYG
     ITLMQYHTKE CINTYSYDMV TKFGGMNDDF VLVVQRTLFA EDEAPIERIV FTMENTKAYE
     ITLLLADYIT HRPRGLDRMH TMRTLPSSNL ISVNV
//