ID A0A0V1D3Y8_TRIBR Unreviewed; 988 AA.
AC A0A0V1D3Y8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|EMBL:KRY56284.1};
GN Name=SLC12A2 {ECO:0000313|EMBL:KRY56284.1};
GN ORFNames=T03_9066 {ECO:0000313|EMBL:KRY56284.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY56284.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY56284.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY56284.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY56284.1}.
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DR EMBL; JYDI01000045; KRY56284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1D3Y8; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 129..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..89
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 132..621
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 630..933
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 937..987
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 109354 MW; FC6BABECB0C8BB72 CRC64;
MENQCSDDNE HVDSSISDHI TKQVHFEIVN ENEEAENETD DRQSAPNDLT CTTANMKTVE
KVPHIDHYRN MMSVVKAVSS RPTLQQLRDG RNVSAESSHD EDQKSLRKCS GLEAFISTKK
FKPQQKLGWI KGVLIRCILC IFGVILYLRL SWITGQAGVL LTLAIVLLAS SVTILTSLSL
CAIATNGELN RRNKNTIDGG AYFLLSRSLG PEFGGSIGLL FSFANAVAVA MYVVGFAESV
VDVMKKHDTY IVDGSLNDIR IISLATAVVI LAIVIVGVLF ETKAQMILLA ILSISVLNYL
IGTTLPKSED MQAKGFTGYS WETFMKNLLP EFRGETFFSL FSIYFPAATG VMAGANISGD
LKNAHNAIPK GTLLAILITS SVYCVCVLAT GFTCLKDASG VLEDLKLGTL SSCAASENCT
YGLLNYFQVM EMQSAFSPLI TAGVFAASLS SALSSMALSN DNLFPYIRYF GRGYGRNNEP
RPAYILTFLI ACCVIAIGDL NIIAPIISNF FLASYALINY ACFDASYSQS LGFRPAFKYY
NMWLSLCGAL LCLGVMIVIN WWATLVTVAV ILILYIYLLR RKPNVNWGSS GQAHALRNAL
NAMHRLDNTE EHVKNYRPQI LVLTGNLSER NHLLNFATSI TKDSCLLISA EVIVSDNPDS
LISTVSAEEA KCTAWLAKNK YRAFFHAVSS ASLSDGVRQL LQISGLGKLK PNILLLGFKN
NWKTSKLDDI TEYVTTIGLA FDADFGVCVF RCNSENVTAS ENVDECKPLM DQADQEEQQQ
TNNPELKTSI NDCQKFTIEM DEDELKSENE TSNNAKPKKT IYQNFSRKNK TLKKQKVKHA
TIDVYWLFDD GGLTLLLPYL LQLPKSYLEG AKLRVFTIAN NKELEHQETS MATLLSKFRV
GCTEVTAIPN ITKKPDQKSL DDFQESILPF LGTGALSESE LLAETMPIPR RRVCSDLLYM
IWLDVLTRGM PPVLLVRGNQ RSVLTFYT
//
