ID A0A0V1D4U8_TRIBR Unreviewed; 696 AA.
AC A0A0V1D4U8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
DE Flags: Fragment;
GN Name=usp46 {ECO:0000313|EMBL:KRY56493.1};
GN ORFNames=T03_12041 {ECO:0000313|EMBL:KRY56493.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY56493.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY56493.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY56493.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY56493.1}.
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DR EMBL; JYDI01000042; KRY56493.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1D4U8; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF944; RE52890P; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00167; FGF; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025, ECO:0000313|EMBL:KRY56493.1};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT DOMAIN 338..694
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 454..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY56493.1"
SQ SEQUENCE 696 AA; 80990 MW; 9A0055EFA5F56017 CRC64;
LPFSWFGYRT MPFWVLNGHS EQQPRETAID CRYLLRQIIK LSVVFYIATK LPLTFLSFQT
DSSMALNFCT NFSLNITAPY VTNMSMTVCL AGTCFLNKIN INMNSIQIAE EIPLQNHVTR
LYRLYNRCSG RYLQMYVKAI NARGKSKSPL TLLKVETDCY GGRVRIQSKK FRKYLCFNRK
LRVTARYNGR SENCVFVERI SENFYTELES ASQKGAFLGF NSRGLFLHPT MRSREPHCFQ
FIKEEQINPI EEFRGIDYGP SRRIRSRAKW KKKNHTQPNI TLTPQLFELL YHSENRSCCC
CCFYWAQKRK RVNFDMGQNA SHLEKETTDE FPANDHFYGL VNFGNTCYCN SVIQALYFCR
PFREKVLNYK SQMKKAGNQK ENLLLCLADL FHSISTQKRR VGTIAPKKFI GRLKKENDLF
DNYMQQDAHE FLNYLLNTVA DILLEEKRHE KRISGGHKVG SKGTTDTVSQ TDGFGDNASS
NQTQVKDKLA EHTWVHDVFQ GTLTNETRCL NCETVSSKDE DFLDLSVDVQ QNTSITHCLR
EFSATETLCN EHKYYCDICC SKQEAQKRMR IKKLPLILAL HLKRFKYVEQ YNRYTKLSYR
VLFPLELRLF NTSHDAVNPD RMYDLVAVVV HCGSTPNRGH YITVVKSQGF WLLFDDDVVD
KMDHINIEDF FGMAADGSLQ KNSESGYILF YQARDI
//
