ID A0A0V1DFJ3_TRIBR Unreviewed; 1087 AA.
AC A0A0V1DFJ3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=PDZ domain-containing protein 8 {ECO:0000313|EMBL:KRY60234.1};
DE Flags: Fragment;
GN Name=PDZD8 {ECO:0000313|EMBL:KRY60234.1};
GN ORFNames=T03_10791 {ECO:0000313|EMBL:KRY60234.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY60234.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY60234.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY60234.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY60234.1}.
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DR EMBL; JYDI01000007; KRY60234.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1DFJ3; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 27..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..283
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 354..438
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 783..833
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 912..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY60234.1"
SQ SEQUENCE 1087 AA; 122579 MW; A42562404899CE0A CRC64;
LHKNKLKLLT DLHALHVKYC FQNWFSLMWN LLLSFVLGGL FAVFLQILFV YTSSSPPTTN
STIRSLPQLS SFRLPTNLKQ LLISPGLSEN LKKKETCTSL NILLQFLFQE LKDSKRLRRW
ILKKLRLEFN DLLSQFAVSK VLRDIRIVRL DIGSQFPLIK SAHVGHVQLS ENEDYFEDVE
IVLDVDYFGG FDISLNFVTI IDSDACLSVK IPRISGELRI RFSKKPFTHW SFAFTEEPRI
NFDIDSKLLK RSLPQVVPLI ITQFRRMLRK KHVLPAYRIR FTPFFENPRH RPFPPHRDLF
FIRPTGCLCM SSIKCVGLNV LNAPLGHTQI IVQFNVGNKL ASMSAEENLP FALVVKLKKL
MAEETAGLTL RRITCVKKNC REVTVVDVQR MSPAARCDLH VGDVILSING ISVHSERQAM
KLLSDGSLEY DLLVERTLDS SDHQRTVSVQ QNRHTGGSLI DNGRSCPRMM MTVGHHCQDE
ENSIRRSRSC FELSTSEEEN SSSAASTGDF CRIEINNKTN GNADESADWN KAEATSSPRK
RCWSYPGMMD SEMQFRTSDD DFEVLNIDDE ILNADCVETA DKLTNSTGEA SAKMPTLNKT
ATCNGGNNQE FYEKTVSGIS LASVSYQTDV MMMMMMDFVL HDPVVIPLTE HWSYLTISLY
TVSSSQDSCS ISRSPLAYVP VFLPEVLYEC SLTESRIHLE KFALKSAADV KLPAELKSLS
RHQGFDAQLC FGAMTLIFQW YPTKSCETVL SEFGMDANKQ ASLAQEFVEP CAKDQSSSTR
EDDHQWVSKS FQEYPFCCVC SKKIWLKSAL QCAVCLAAIH KKCLSKAYLL GGCGQVLEAT
AKDSVVDSYD ATVTEEGTDA AAYVDEPLVD EKPPVITAPL SRTGITRASV QSAVSKRLAN
IKLNRASLRF NRAPVKNSSD KSQQRSTDGQ LEMKLLTGDA DLEEESASND EYNNLLNSLA
SGDCDDPNDS VTSSILYTPC GTYNEHVIRA AKLTGKNLFS DIPLEERKAK INQQIDKLQM
EINAVSNLRL QFLQQQKKLS APDEKLEKKL NKLDETLQVC KIVKKMKLKN RNKMQNMKAK
MEKKLKH
//
