ID A0A0V1DI92_TRIBR Unreviewed; 1439 AA.
AC A0A0V1DI92;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:KRY61035.1};
DE Flags: Fragment;
GN Name=APAF1 {ECO:0000313|EMBL:KRY61035.1};
GN ORFNames=T03_10714 {ECO:0000313|EMBL:KRY61035.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY61035.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY61035.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY61035.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY61035.1}.
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DR EMBL; JYDI01000003; KRY61035.1; -; Genomic_DNA.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:KRY61035.1};
KW Protease {ECO:0000313|EMBL:KRY61035.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 13..77
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY61035.1"
SQ SEQUENCE 1439 AA; 164070 MW; 8ED17C529FF9FA21 CRC64;
LLWVRSKFNR IMLSEEQNLK LLNSQHSLLT DLEPKEITAY LQAAGVFSED DIELINAKVT
RRERVAELLT IYRRKARDLG PLVYALDKTG YRHLKIELVN SVSQVDRGAV PNSKHSLNIL
LINGKVPRKP EVYVERKEMK LKLKTALMRI DKEPGWIVLH GMGGCGKSVL AAAVVRDSEI
TGGLFSRVFW ITAGRNCDRI RSFALMQDLY SKMGKEFHRL DSVEEASSRL IELMLFDYPR
TLLILDDVWT ESVVRLFDEL QCRILALTRN ASLFDVANNR KYFVLMEPSG YTRDEAMQAF
ASYLNCSESD LPLEALQIFH ECRGHPLLIS LIGALLKEHN SRWKFYYGLI HSQKLNNIKK
VTHYKYATFN EAALLSLEDL TDDLKQLYFE LAIFPLGVKI SSQVLTVYWN KSIYEVEDIM
AEFVKRSLLI KSSSDCEAVE TYQIHALLHR VIKMSCHSDL RKTLHQKLLG NYLKVADDCW
GKLPDHEYIF TFLGYHLFRA DKFASFSDVF LNLKFLAKKI ALCGPSSVLN DLIYYRKFIR
DSHPTLFDQI ERLIKNNSFQ LATNNGKYLS LIHLSLLNKN LSELYLEAER ILQESDSSAV
VDGFAKPYLK SWCKQSFGKD PNFTFSCNSV KTGVWMSRQK KIIYIGFDSC LGVCCTTTGL
QLYRVVLNHV PNYLSFSDND CTLFVAYGNY VGVFELDDHL KRSSTEQDDL DCQRTPSPIL
NHLCNGLGFI RANEQQQDQM HQDQQQQQQQ QKVDENILGP KLLQMREFEV DDCGVELRFC
LPARHYPWVL CCDMEGSAKI LEISQGRVSG GLDLQSRRND RSTTMHITSC GFNGDDSLLA
IGRADGVVEL WNPADFGLRC RFAGHHSGPV LFCAFTGRFT SVECIFSACE RRILLWKFDH
SRDHDNDLQQ SNSVELLEKI QPDQKHVRIV CVALSPTENL LAASFTDFSV LIWNLENKLS
TYLVGQCRIL KQLYFSEKGK DLLAVREDNA VLIFNEIHKS NTSIPEINLI DFVEIKTALL
LASVQDYTLQ VSIITDTVGS VIETRRLFDR VSCLKWSPNE CVLMIGFENG WIQSCQFDGN
SLSELKKEFR TPQAPCCLAF STVSDRFAVG CKEGCVAIQD AVIHCHGTAF FETAVTKCIF
IDRHPHMNRL LICLQDGSFE ILNIDSFVVE AVLGLPVCMI IDFDVNSNCT YLATCWSGKQ
VKVWELDNLN PIFEENNFNN SLSKCKLSQS GNLLAVCESR GMVNLFKLPG GDLVQKIYAH
SADIYDLVFY DDDDVLITLS AELKWWNLKL KSNQMRHWLL STDSAKTLNI FPGHNLLVTV
DHMQGYHVMQ IVSTGNLPVG RINASTSIPP LSSVFKLKFP CRCTYRVCIF NIAAQIQMRT
LDAEIKHTES QSLTSKQFTL QNGCDILNQM FFLLRIDLGR LVSSIKLCNF NYQYTSEHC
//
