ID A0A0V1DIR1_TRIBR Unreviewed; 358 AA.
AC A0A0V1DIR1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial {ECO:0000256|ARBA:ARBA00016714};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
DE AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|ARBA:ARBA00031181};
DE Flags: Fragment;
GN Name=HIBCH {ECO:0000313|EMBL:KRY61485.1};
GN ORFNames=T03_9518 {ECO:0000313|EMBL:KRY61485.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY61485.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY61485.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY61485.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY61485.1}.
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DR EMBL; JYDI01000001; KRY61485.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1DIR1; -.
DR UniPathway; UPA00362; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KRY61485.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653}.
FT DOMAIN 47..247
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY61485.1"
SQ SEQUENCE 358 AA; 40324 MW; B2A12257DA254A6E CRC64;
LMSTMAAFLN KHFICANKLS ISWISATRSL CQSASEVLFH ESNGKLLVTL NRPTALNALN
INMAKMMFEK LKKTNTDNSI KMVILKGAGN RAFCAGGDIR ALALSIKNND GLVEEFFREE
YKLNYLIGKF RVPFVSLIDG IVMGGGVGLS VHGTFRVATE RTVFAMPETA IGLFPDVGGS
FFLPRLKNKL GFYLGLTGAR LSGEDVYEAG IATHYVHSKW MPELQSELIN AKEINSRSIK
TILDTTVEEL FHKLKEDGSQ WATECLETMK KMSPTSLKIT LRQLKAGMWL EFRECFQMEY
RISQRCVKEH DLTEGIRAAL LDKDKTPKWI PGTLEEVTEE DIDKYFKVLP AERELYLP
//
