ID A0A0V1DJE2_TRIBR Unreviewed; 902 AA.
AC A0A0V1DJE2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Pre-mRNA-splicing factor ISY1-like protein {ECO:0000313|EMBL:KRY61557.1};
GN Name=Isy1 {ECO:0000313|EMBL:KRY61557.1};
GN ORFNames=T03_2348 {ECO:0000313|EMBL:KRY61557.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY61557.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY61557.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY61557.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the EMC6 family.
CC {ECO:0000256|ARBA:ARBA00009436}.
CC -!- SIMILARITY: Belongs to the ISY1 family.
CC {ECO:0000256|ARBA:ARBA00007002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY61557.1}.
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DR EMBL; JYDI01000001; KRY61557.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1DJE2; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:InterPro.
DR Gene3D; 3.90.550.50; -; 2.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR029008; EMC6-like.
DR InterPro; IPR003378; Fringe-like_glycosylTrfase.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009360; Isy1.
DR InterPro; IPR037200; Isy1_sf.
DR PANTHER; PTHR13021; PRE-MRNA-SPLICING FACTOR ISY1; 1.
DR PANTHER; PTHR13021:SF8; PRE-MRNA-SPLICING FACTOR ISY1 HOMOLOG; 1.
DR Pfam; PF07019; EMC6; 1.
DR Pfam; PF02434; Fringe; 2.
DR Pfam; PF06246; Isy1; 1.
DR SUPFAM; SSF140102; ISY1 domain-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 501..601
FT /note="Fringe-like glycosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF02434"
FT DOMAIN 668..878
FT /note="Fringe-like glycosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF02434"
SQ SEQUENCE 902 AA; 103256 MW; C24DA03C2DE4222B CRC64;
MTRIEFEISN IMLMCFIKYA SLKTNYKMRT VISDLWMVHR YKRGKMARNA EKALTALARW
RKMKLDEERG PTDHRPALAS ECNDLRKAEV WRLDVIREIA RKIAQIQNPG LGEFKIRDLN
DEINKLLKTK YHWEVRVREL GGPDYKRIAP KMLDREGREL PGNRGYKYFG AAKDLPGVRE
LFAKPTSDVG KLKKTYAQLV RAADARYYGY VDEDDGVILP LEYEAEAAAR KKAVEEWEKN
KMDKFADELV DKVDLPTVED IGNFEEENAA DILFPGDDST DRPVNVEDVS TGSIPVPSQE
EVEQAILKRK KMELLEKYAS ESLMKQSSEA KSLMGFKLAE IFAAFGIIFH ASMLISKKAG
ELFSKAIQAK SDWTDKDDLL DVIYWFKQIF SLLFGIGCGL LPVEGFSVIA FYLMVSTLVT
HFYITAFQCF DEDELGGISE VFKEGFSSAF ATFMNAFCLL NFNNFEPCEI VFVYVTEPIE
KQGVSADLLK EKLIRQTNFT VHVYFTHSDF STTTGAWAIW PILHNKLQAV QYKWLFFMES
QTVVDLMRLT QLLAKFDPAK QFFIGHALID HSMTIIHHFS SEKLKYPELG AGFVISKATF
NFAVELVKSN ESNAQMFIID AMYELALLLY NNSFGVELTD EPMFCTLAEQ SNCITRYVYD
DSKCTGNVSS EDVVFAVKTW SGNHQTRIPI LKQTWVSNDI QVIFFSDVED RNIPTVKVNV
ENTKEGHCEK TLNILQYFNE INNRKYKWIV LADDDTLFNV AALFRLLRCY NSESQMILGQ
RYGFHFNADG TRGFDYPTLG AGAVFSSPVV STLAFLLQCT AKDAPDDMSI GFYLSNTDIP
IVHSSSFHQA PSSSYAHDYL HKMPMISFHS FFNGNPLENF ERYLKKKHLR NDEEEHLAKI
EL
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