ID A0A0V1H0V1_9BILA Unreviewed; 1830 AA.
AC A0A0V1H0V1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Voltage-dependent calcium channel type A subunit alpha-1 {ECO:0000313|EMBL:KRZ04279.1};
GN Name=CAC {ECO:0000313|EMBL:KRZ04279.1};
GN ORFNames=T11_14426 {ECO:0000313|EMBL:KRZ04279.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ04279.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ04279.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ04279.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ04279.1}.
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DR EMBL; JYDP01000168; KRZ04279.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1043..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1123..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1255..1290
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 19..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 223
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 536
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 903
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1830 AA; 208996 MW; C44FEB960AEE709D CRC64;
MNLRIDDIAR LASERTKLQL HSQSLDSSAD KSSQARRIPG KHGDGKGPTS LFIFTENNFV
RRYAPTEPYF MGIFTIECLL KIIAFGFVMH KGSYLRSGWN ILDFIVVMSG VISMLPFTTS
GVDLRTLRAV RVLRPLKLVS GIPSLQVVLK SILCAMAPLL QIGIPVAIGN KPFPCTNKST
TGAYHCPEGT ICKEQWIGPN YGITSFDNIA FAMLTVFQCI TMEGWTNVMY YTNDSQGDTF
NWLYFIPLII LGSFFMLNLV LGVLSGEFAK ERERVENRRE FLKLRRQQHI ERELNGYLEW
ICKAEEVILN EERTTEEERK AIMEARHLAV SKQLKHLVQQ STETEDDLEE DLDVEFRTKD
LSQTGKCWLS FRAAFCENTV FLLVGDNTDY AEWTFLGIFL FEMLFKMFGL GIGTYFQSSF
NIFDFVVITG SLFEVIWEEL KGGSFGISVL RALRLLRIFK VTKYWTSLRN LVVSLMNSMR
SIISLLFLLF LFILIFALLG MQLFGGEFNF PEGRPSTHFD TFPVALITVF QILTGEDWNE
VMYLAIESQN DTLLNVFLAI AVDNLANAQE LTAAEEAHEQ EVQSTYSSAD IKNDECEYEK
GPKMIENLSQ NGQAKLTDAC DAVCDVKNAL NIQENKTATS APLCYVNSID ESDSNCAFGG
HREIVPYSSL FIFSPKNRFR LFVHKIVCTK YFEMAIMVVI SLSSISLAAE DPVDESNPRN
KYLNYLDYAF TAVFTVIDMG VIIHPGSYCR DLWNIMDATV VICALVGFAF VDSTKAGKNL
STIKSLRVLR VLRPLKTIKR IPKLKAVFDC VVNSLKNVFN ILIVFILFQF IFAVIAVQLF
KGKFFYCTDR TKRFEQDCQG YFFHYDKQGS PPQVLQREWT SFALNYDNTI HAMLTLFTVT
TGEGWPGIRQ ASIDATEENQ GPIPFNHIEV ALFYVVYFIV FPFFFVNIFV ALIIITFQEQ
GEAELAEGDL DKNQKQCIDF ALNARPVCRY IPEDKDSIKY HIWKMVVSTP FEYFIMAMIC
LNTIILMMSY YQEPPAYRAV LRYLNSTLTA VFTVEAILKI LAFGVRNYFK DGWNIFDFIT
VIGSITDALV TEFGGNFVSL GFLRLFRAAR LIKLLRQGYT IRILLWTFVQ SFKALPYVCL
LIGMLFFIYA IVGMQVFGNI ELNGDTEINR HNNFQTFFNS IILLFRCATG EAWQEVTLAC
IANRKCDPRT GKLNNECGTN FAYVYFTSFM LNLFVAVIMD NFDYLTRDSS ILGPHHLDEF
VRVWAEYDPE ATGRIHYTDM YEMLRNIPPP VGFGRKCPYR LAYKHLIRMN MPVDEDGTVQ
FTTTLFALIR ESLSIKMRSA DEMDRADMEL RKTLKKLWPI HAKKNLTDLA VPPNSKLCNK
KLTVGKIYAG LLLLENFRSK RCGRVPDRST FLFGRLVDAA LKEKEKIHSS EADPSSCTEL
FSDSEPPRSE IRYGFEHQRR MLPTAEQPRI FDIAGKWQTH DEMNSQMQSV YVPQDEYNNE
RVRHRRKVLR RQQEDDRVDN FASAQEWHNY ARQRIQRCTD SKNKALSERT NLDRYYMTGL
ADTKSHHESA GNVLFNQLSP VLGHSFSPAF AEKIPSSACY FRQQLPMVWE NPVVNKFSEV
SHLKAHPMFK SSPELQQCAG KRRRLAAKTA RTFCTSTIRA HREVENYAEF LQLSDDESCN
YSARSAKQTV FDSNLMSPLT VSPDPAFFSS SSSSSDTSFV NVSCPAQQNV NTPSYANYCQ
ISPDNSYIFA GNPTSSGEQA RSSQSSGATY KLSGYKTTVH CQPAFKEPNQ QRLYYMRSNE
SNAEEHRCHS VVHSQPGHIP LSDSEQEDWC
//
