ID A0A0V1H5Y0_9BILA Unreviewed; 1377 AA.
AC A0A0V1H5Y0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Metabotropic glutamate receptor 5 {ECO:0000313|EMBL:KRZ05795.1};
GN Name=GRM5 {ECO:0000313|EMBL:KRZ05795.1};
GN ORFNames=T11_311 {ECO:0000313|EMBL:KRZ05795.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ05795.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ05795.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ05795.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ05795.1}.
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DR EMBL; JYDP01000131; KRZ05795.1; -; Genomic_DNA.
DR EMBL; JYDP01000131; KRZ05796.1; -; Genomic_DNA.
DR EMBL; JYDP01000131; KRZ05797.1; -; Genomic_DNA.
DR STRING; 268475.A0A0V1H5Y0; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15285; 7tmC_mGluR_group1; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRZ05795.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1377
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007438546"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 608..869
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 878..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 154021 MW; 13512F4F96127934 CRC64;
MPMVVVGVWL AVSLTAVLAP KSASHTRVAR IPGDVEIGAL FPIHRKIAGT ERCGEIWEQY
GIQRTEIALK TVDAINDDNA LLANLKLGIS VRDDCWTERI AMEQTIIMVR DAVGGPNAHS
KQQRCCCCPE DKHCQANDGD DPTSNLVAVI GPGSSDVSIA VQNLLQVFHI PQVGYSATTK
ALSDKTEFKY YMRMVPSDSW QAKAIVDIVK YFHWSYVAVV YTDGNYGEKG FEELQKNFDK
EDNLCIGVAE KIKSLAPAAD YDALIRLLMT HRPQITVAIC FCEGDTIKRI FQATKRVRES
LQPDGNDTYQ GLQWIGSESW SDRKDVVAGV EDVAAGGFSF RIYSPRMTQF DSYYFNLTPK
NNYRNPWFVD FWEEKFQCSY TESTRNFYSK ICTGNENVSY GYKPDPKLSQ VTNAIYTVAY
ALDAMYNDLC KGSKEKGLCE AMTPVDGTVL FQYMLKTMFR DPSGQEIYFD ANGDPPARYD
ILNYQGKVAS YVTAGEWDHS FHSDKFNHQS GIYYKSKLRI DRDKILWHNH MSGLTYTPTA
RCSYDCKVGE IKKIQTLKCC WICVPCYENE YLLNEYACKR CPLGYWPLEN RTACYKLEVE
YMRWSDAEAV VCVVFACVGI IATLFTIIIF ILHNSTPVVK ATTRELSYII LVGLLLCYMT
TFFIITPPNM VSCIIQRIVP GTAFSMIYGA LFTKTNRIAR ILAASKKITT KRRRFLSISA
QVTITGLLVL IELITIVVFL IFEPPKADFD YSLPKRVLLI CRTSGLTFFA PFGFDLFLVG
MCTLYAVKTR NLPENFNEAK FIGFTMYTTC VIWLAFIAIY FGSAKKDTTM CICFSLSATV
ALILLYFPKM YVILLRPEKN ARSYFKTTTT IRCHFGSNAK SSSSDGGGGG GGGGGSRISS
VQGSQRKKRW AAVRHRTQIL HSPAGRYVAR SDSYSSYSAQ STPDPTTRER RHSGRFFAAG
DEFSSRDEQQ ADESACKPDE CSSDSQRLLR VIDEMPSVKE ETDDDDDEPT SSEQHPVSSC
KFLDRTGSLW RRFDPFQQNP RLNRGWRSLR VPAGRNDGEA APTLLLKIAA ERLDTVRHFI
DVDAPASAYN TGTTAERQPP RSNVSTISGR ASFARRKAGT GHVWFSSSVG ETDDDEEEDD
HDDEYKDKKM MDIDRRSTGE RLLHSHKDRV VVCQNSQPES GEKQTAFSNG GFPVIEFDEV
DMRTVVLRQS TNKNAAGEDP LPHRRPWARK VRSNSDTVAW LLQRQSQLSN LTWNLTRSES
EQLLAPVRGN SLKTIFTRKA FAKQQQTKSM PCLRFDSAVD TTGTAAKQQY SSPGSSLVTT
ALTGFSRAGS MSGSLLLSPI EELSSSSSSS GSAKSSNGSS PTSVTVSGYD FSTISLV
//
