ID A0A0V1HBG3_9BILA Unreviewed; 1563 AA.
AC A0A0V1HBG3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tight junction protein ZO-1 {ECO:0000313|EMBL:KRZ08158.1};
DE Flags: Fragment;
GN Name=TJP1 {ECO:0000313|EMBL:KRZ08158.1};
GN ORFNames=T11_11405 {ECO:0000313|EMBL:KRZ08158.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ08158.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ08158.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ08158.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ08158.1}.
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DR EMBL; JYDP01000091; KRZ08158.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 88..175
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 187..265
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 427..506
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 704..806
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 1422..1563
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 35..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1216
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ08158.1"
SQ SEQUENCE 1563 AA; 171620 MW; D75BF3923E345093 CRC64;
LPNKVKVVDC MANTPSDVIS GLAENRPDGT AAVELHNDTS KDRPPSTSNA ELTGSSYEVP
MGKNSSNEIL VEPVDEEDCD HTTWIYHSVN LKKVQGYGFG IAVSGGRDNP HFKSGDPSIA
ISDVLRSGPA WGLLQINDRI VYVNGVNLEN ADHSTAIQIM KDSENLNVIV KRRIPFPVLE
YDQRTLKFTL TKSRRKDDFG IVLGCKFFIK DITNRRLAEK DPGLKEGDVV LKINGENCDQ
MTLSEARRLL DRSKDRLSLV IQRDVPRGAN WKWSSQATLY ERIGGTDTPR QSPTPRHSPM
VYVRNADHDT SARSHFPSRY HDRYSRPPSE DRTVSPKRQS TCSQQSFGSR GPSQNQYFYD
DGASNVFPCQ SPSRTISPSC DSSHASVNCA TMDQQLLAHQ KPPLPSTMQV YYTVPYHYLY
HLNEPRLITF RKESGSVGVR VIGGNEVGIF VSAVQSDSPA AVRGVRPGDK ILRVNNKSML
GVTREEAVLH LLGLQDHVEL FLQYKKDEYE RIRNQNIGDN FFIRTHFTYG KPENGELSFK
KGDIFQVIDT LYGGTVGSWQ AICVSSPSMA STRSDYVHPK GVIPNSSRAE QLAHAERSQS
QSQVNTEMKS STLLRRKVTM GRRSKSLTKS HWDEVVFSHG TVHFAAYERV QLRHPGFLRP
VVIYGSLADV AREKLLRDFP LAFLSSQVEN GNDESDPGKT NRIVRLNAIR DVMNKNKHCI
LDITPSSVEK LIYAQYCPIV IFVNVGNRTR LRDLRKRLAK TSAMKSSKKL FEQSQKIQKL
YSHLFTAVID ATHEEKWFEV LRDLIAHLQS RRVWMSESKP SELLDDDFLF PMSNGRYGSV
GGGDSDVDSI ADEPRCDLSS KRDAAVALTA VDAASRMDVP YADNSSSSSY AMASGTLRSP
TKTHGHMCDR QSSGSNVDMI ASMYENRDNI VALMATMRRK PPPLARKPKP PPPPRIGSSN
ASLTSDVQCT VDLAAPSADL PRIAESAVSV APSAACNGST TLMQTSFSAA THADNSRLLT
KIDEREFVPY SPRYGRPVAD CGLYNVKQIL EGTMDNYDSG ISAPMASSRL MHSSSSALGH
PMTGKPNLTE SMSLSYYENT ERARLDYSAS LGLNSHGAAW QNYEHPSSYV SAHSNNSQFQ
HFFDGHRVCP VSPTSSGSMA ATMRSVNGGI YGSRSSHDSY AQHVSEGYLL AGNGSKRPPM
VPHRSPVPPP APRSTYTPST PRHSQSVPPS MSSCGSRVLN SEDDDQQQHQ FGRINSPSLG
RSQPQPIPLA RSSLTKAHTT TASAAASTRM SDSSTVHLSK SDAAGAGAAV GSDLQPNNVN
RAAAVRCDEA LDMSSGEAVK SKNNNSDDDG NEFETQTCTK QVAVGGGDDG DDDDHHDDDH
NGHPVSDVPG SKKKQQCGSS FFEEENELGT IASDADLFIC RSSASATVDH SGATLQLQDV
GVRLIIPQAA LSSPVEMFVQ LMTRELEPRT SNGAFPSDET SSFKEKNCFV IVAGPSGLKF
SVPVEICLPK SALNDGKQWF LAFKSSKNAD YFGQRRCLNL LDSCAFPKKN VDPDQVAFSI
SNF
//
