ID A0A0V1HDS1_9BILA Unreviewed; 1034 AA.
AC A0A0V1HDS1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=tubulin-glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00026108};
DE EC=3.4.17.24 {ECO:0000256|ARBA:ARBA00026108};
GN Name=AGTPBP1 {ECO:0000313|EMBL:KRZ08721.1};
GN ORFNames=T11_2707 {ECO:0000313|EMBL:KRZ08721.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ08721.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ08721.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ08721.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] +
CC H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-
CC glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA-
CC COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555,
CC ChEBI:CHEBI:149556; EC=3.4.17.24;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ08721.1}.
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DR EMBL; JYDP01000082; KRZ08721.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HDS1; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.60.40.3120; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR12756; CYTOSOLIC CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR12756:SF11; CYTOSOLIC CARBOXYPEPTIDASE 1; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|EMBL:KRZ08721.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000313|EMBL:KRZ08721.1};
KW Protease {ECO:0000313|EMBL:KRZ08721.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 760..980
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|Pfam:PF00246"
SQ SEQUENCE 1034 AA; 118458 MW; 3D41EC6207BE179D CRC64;
MVNAVDLCRK LCQQHTIGVN KDAEEWSHLA QQLHTKCSAD ANDKSVQELW DNFENIDETL
LLNFLLCFEH CRNSEAIVWF TRILHQFISR PSADPKSRLQ LMAKLNGVSF LCKCLRWFLQ
KFDETDEMVN VIQALIPVIQ IVGSVDGRFF MKVRFVGLLD ICINVMCNVA QYPLTESLLD
FLTFACRSGQ NASALVKNEM MVPFLKKVFA ECEMTTPAVI RKYAELLFLM AKPKKTRKSL
VSQGIIPSVL ELFQAFFGKD DDTSQINCNA ALGTLRLLTS TISGRQNLVA CNGLEIFRDL
IRSFDESEAS SPLCSHMYHS ISSLCIRCLP MRPLPIENMK YPVDVSIVEI QHSTPDPPEA
VSDSEDDIFV AAGFLTDTDD EAISHASQNE KPPIPLRMFQ KETHWYRFLT RELDYGTLLS
KDSTFGNVLA KQTDNMLSEM ADLENFMLET NQRQRRKSIS SLREIRLSGK HRSITEQLLE
KSQSGLPTWY HWIDYICQAV STRSVIPFET LGYPDIHGCY PNLPQQKLKC YPNALLNMVG
HLLERLESNK DYIPKVVYDL DQLVTTRRTY DGSKFILNND IVKLGSSNPD TTSLQFESRF
EGGNLRKVGP YEYDLILTPD TNQMNEHYHT YYFQVSNMLT EISYTLNIIN CVKTRSLYNS
GMQPLVFSVT EALLGRPGWV RIGGNCVYYR NFYSRASSST PAKSSETVTS YYTASFNVHF
RHRYDICYFA YHYPYTYTML KTHLVKTNQL LSLKKDIHFR TDVMCHTLSG NPVILVTVTE
LGDRIQLKSR DIVVLSARIH PGESNASWMM HGMINYLISD HPFAKLARSK FIFKLIPMLN
VDGVINGNHR CSLAGKDLNR QWVAPERSVY PSIYHTKNLI SYLHRIGRTP FVYCDFHGHS
RKMNVFVYGN NPNLSWYSGD RLQKHGFEFY QFPEILDETS TAFELKYCAF TIKKNKEGSA
RVAVWRDTGI SRAYTLEASY AGFDSGGYKG HQITTRDLIE MGEQFVESLV HLKKNVEQGK
SPTRRFEIGA KQKE
//
