ID A0A0V1HHG0_9BILA Unreviewed; 2652 AA.
AC A0A0V1HHG0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Voltage-dependent calcium channel unc-36 {ECO:0000313|EMBL:KRZ09620.1};
GN Name=unc-36 {ECO:0000313|EMBL:KRZ09620.1};
GN ORFNames=T11_9385 {ECO:0000313|EMBL:KRZ09620.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ09620.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ09620.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ09620.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
CC -!- SIMILARITY: Belongs to the peptidase C48 family.
CC {ECO:0000256|ARBA:ARBA00005234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ09620.1}.
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DR EMBL; JYDP01000070; KRZ09620.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 1.10.418.20; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.30.310.130; Ubiquitin-related; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR003653; Peptidase_C48_C.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR Pfam; PF02902; Peptidase_C48; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50600; ULP_PROTEASE; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2652
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006879154"
FT DOMAIN 259..444
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1280..1332
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1740..1917
FT /note="Ubiquitin-like protease family profile"
FT /evidence="ECO:0000259|PROSITE:PS50600"
SQ SEQUENCE 2652 AA; 305188 MW; 6BBDDD6E2AC560CC CRC64;
MTETSSAGLL FQLFVLAAEL HAQDLRGRGA IPISASMCVL GVEQWAKSFG LDLYSTATTA
TQAEELEQKY QEKNARVEYF DPEEVIDVMK ARLEKFLGRR RQLAEILKEN LENSYSLFQM
VDREAINDLQ SDDFYRFVDS KSCLNRHYVD PLLINSSLSV NYIPNPNFFN LPVNTEKSAV
HVPTPVYARD PELLSEIIWT ESLDDIFKAR RAREFFAASW QYFCSQKGFM RFYPASPWFY
DDSHTCLDMY IDAATHAKNI IIMLDMSGSM LGQRFEIAKQ TIEMILETLT ENDFFNMIVF
SEEPKFILSC FRNRLVQATI KNKKLMRVTL DNVTAEGIAN YPAALSLAFE VLIEASQNPG
VNSGCQNAIM LITDGPSDTY EDIFEKYNKD KMIRFFTYLI GDDVTETREV RWMACYNRGY
FAHISNLADV QEKVQSYIGV MSRLTAERNR TDPVWTGAYY DRLGAVLVAT VAFPVVANDS
FRGVVGASAL ITELQQMAPL YMLGTHSYTF IVDNNGYVVH HPQLRPLYMG KAKPHYNSMD
IMEMEVLADN YLENGSLANP VDYDSDLRRH LADGVSSKDF LRKFSQKIIW ACDGSNNLRR
VYLQNNVYYY RGINNTLMSL ALAVPEDSRY RIALPSTYSP YPFKNIDCKT VKWFSGTNWR
LHPDWHYCRI NDSDYSMTKE EAFVINMRHY SETGRIARNC ALYTYLIERL LFDAEVTSQM
DSAWIQESRL DERKGVHLVY LATHAGLTRF VSMDLKDVQY QPDVQTWQSD DNRTEELPVT
LDKPYFHFSK RHTRALDEVF YKRAMQFLNG EFVFDVNITN NIYLKNGSQT YPHAKDGRSI
IVTGNRAILV RDDYGNEAPA SVVGFEMLYA SFEEMIYNAS HKMCHFNSKV RCYLLDEHGY
IVYASLPHTS QERVHYLRQF FGHLSLENTE NGAIERYLMK KLVDLFVYQK LLYVDFQDLC
QNLNLYNSAR RLFNPLLTVS KLIISMLQKM IRFFLEINPL GIIFSLFSRY TTTFRDIQDG
LPCDRASSFY LLNNDFRGPL TLAEGKQLCS SVATSDSYAR VSSCNLYAYA VRIEKTNLVL
VVYSTEGTQC NGDLCKDYFS RDSLPWGFSI ALNATDKVMH PQACKLTTRY RRPPSACQAM
EDDDPFAHCS GCSSQATLLL VLLCVAVLFT ECKSAHRFDG ECIFEFTILY LMQPEVDSVP
SAEVVPSDRF WATMLTTLSG VSVEELTSAI AKCKDLVLQT APMSAIRREL VRRLIELRQK
LHELKDGLTQ DSKFDATVMG HQFKTPSRTI LERRYCECCG GLIWAFLQPW YFCRLCGFYV
HVKCVKSVKR QCASLTVNEN PVFELEICPE RGLAMQNFQC ADCKTEVSID SSLMVEASQT
ARLCHYSGSY FCSVCHWNDE MVIPARVIHN WDFTKYTVSR CSRQFLRLMQ KRPILRLEAM
NSCLFKNIPQ LQKIKAASQC LMTHLRPYAH FMEALDVYSI RDLIDINETV LESRLMQALE
IFEKHIKNEC SICQGNGYVC ELCDNSEILF PFDRSVGKCG QCSWIYHKSC FDKNNGICPR
CLRMSSRMAI RLLSKDSNTR TSSDKCSLSL HFISSHSMCF VELDLHPRYS SLDLLSAIDC
LYRVLYLEKR EESRRRMGIW LSLQSKNEDQ ITNESTFLFS LMTKIAGDFG AVELVGEDKK
LNFMISKRLL SKIECYPDVV EAALQASPTR QQQRQRVDGR NQTTETGQRL AIRYNDVDCI
TLYEEHLTCL LFDNWLNDEV VDFFMVLLLE LLNDYKNYDF CFLPASFLES IKRGRDHCVL
RRLNVFEKKF IVIPVCHNYH WTLVILCYMN NMAAALNGRV DADCSPFILY VDSLHWSINK
RILVELRHSF SRELGIRLNV PDIKLGDNEL PYKIVRVPKQ KNLSDCGVYL LHYTECFIRY
AVQKSFNVHQ FLEESLKFFE LSSGASKREN LKNTILVLAL PSCKFVRKLP SLNDRSASIL
PASMNCSESE NGRLRTSHDV EVMRKNLLKE FKTSMKKVRV KNEEVVFPNC SHELLEIQWN
SDRFFQRKVC SLLLLKTKQQ LAFSGSVEFA LLLGRCHVFG FELEASIPPK FQHVFSSYYG
SPLISFNTGK RTIDESKVKT HEFIEFCYVN VLKPLITKAM MKRIQSAAAV LIIRCVQLPL
PLGTSFERMS MIEPQNCTIR NNCSTISEKH ALIPGIFLVT KKTKLHAFSL TSKEAVLFDK
ATSQTQRFAK SKRYSILFCG HIASGKSTRL KYFANRLLSR RVKTYLLDLD LGQSEMTLPG
CISLTKLDEP LYGVNLKRMN KCEICYFYGE ISPSNRPKIY LQLINRLYEE YLKITEDGVL
LINCNGWISG LGLDILLSIV DSLKPDKIFF FENCNIQMSE AAASRVARLA LEERTQIKFV
GTSHLRVLQT LDKKLLRSHS ICNYFAHNYK EWINFFNAPT VHLQWKKCFI AVAHANVDGK
FIMCLLKASV VGLCHLSDHN AEDPCEEHYC NDESLPAVAP PGAVPLCIGF GIVSYVDTDD
QTIHLRTPLS SEQLDKVNLI VCGELEIPQQ IFNCQSLLVN DNSKLTHKHN VRLMADIWRH
WKNINIEYKQ FFSFHKQLQF QWLKLVDTSQ QSKCQTSFSC TVLLFNFNYK SFDYNLLKQF
VEEQTTKIGL SS
//
