ID A0A0V1HKJ6_9BILA Unreviewed; 1065 AA.
AC A0A0V1HKJ6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Translocation protein SEC63-like protein {ECO:0000313|EMBL:KRZ10245.1};
GN Name=Sec63 {ECO:0000313|EMBL:KRZ10245.1};
GN ORFNames=T11_11645 {ECO:0000313|EMBL:KRZ10245.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ10245.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ10245.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ10245.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ10245.1}.
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DR EMBL; JYDP01000062; KRZ10245.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HKJ6; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd22674; FHA_PPP1R8; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00498; FHA; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..104
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 449..510
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 282..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..870
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1065
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 121824 MW; 21F209FFF3B6F7E4 CRC64;
MLQSMPEMET DMDAEKYIVP GWAEKFPVGS HLDVMKNSTV VQKLLLDEKK AYYFGRNPQL
CDIVIDHASC SRIHAVVMYH SVLKRGFLVD LGSSHGTFIG KVRLPPFQPQ NVEFNQEFRF
GASTRAYCLR PPSEKFEKGS QSFGEPMDIG ANESSNDEAV LDALTEYNTA LNRQLPIIME
DAPKPLNRKR KAKCVSFVDE EEIINPEDVD PNVGRFRNLV QTAVIPKKKQ HMVEQAETTI
EKNLEPVKKI MQATNRESGS SVSRPKHPLR INLAPEVELY ERTLPDPKND SKAEQGIAET
SKSARDSSSG REKEKKKKIL ARKSSESTSA LRTWKNECLR FNFSMPGQQF EYDERGSTFY
YFLASFYAFV LLPLTYYFWP REKERERNSD VKRCRCEPCI QKEAARRSKE PYKNLKRKII
KFHLLVGWAG LICIIYKAVN IEIEGAEYDP YAILNLDSSA TLAEIKKQYR KLSMEHHPDR
GGDSKVFVAI AKAYQALTDE DTRRNYEEYG NPDGPGALRF GIALPSWLIS KEYAIWVLGI
YALLFMIVLP VVVGSWWFRS IKYSADCVLL DTRQMYKYMF HRTPNLVPKR LLTILSGSYE
FFKVCNSEII ERPSDDVEVP NLIKLLPNLG ETKKERPFCF PYSVKARALI YAQLKRIPLP
PKTLRQDANY IAKKSILLIQ EMIKVHAHLV NLALMGRKCQ HWKRNVRTCA DLAALPEVER
RSLLKALSDR QYQDVISVLS SMPNIDMSVQ FVVRDDDDND TITAGALVTC VVKLCRTALL
DVPGNHGKRA AQQQWKSAEL SSAVSVATDS EGASNPEKDS NGYSSVQDNG SLVDGKEATN
KRKVWEKVKK KKKKYVPKCA NNNKRKPAIK KPLPKTVEPA KTVPEKQQDE ADLDVEGSGN
DSDDSMNKPD NAKDSGDGSE DEEYLLNDPD LKKERAILET KSNVTHPVHC PYFCEEKFEW
WWIFVCDRKR RLLVAPPIHV TTLVNEEEIE IKFPAPIKPG QYVFQVCLRS DSYVDFCQFK
DVKFKVHEAC EILTHPQWDF SEEKTDEEQL DESEFTEYED EEESS
//
