ID A0A0V1HMV6_9BILA Unreviewed; 727 AA.
AC A0A0V1HMV6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
GN Name=FARSB {ECO:0000313|EMBL:KRZ12094.1};
GN ORFNames=T11_4586 {ECO:0000313|EMBL:KRZ12094.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ12094.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ12094.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ12094.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ12094.1}.
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DR EMBL; JYDP01000043; KRZ12094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HMV6; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00769; PheRS_beta_core; 1.
DR Gene3D; 3.30.56.10; -; 2.
DR Gene3D; 3.50.40.10; Phenylalanyl-trna Synthetase, Chain B, domain 3; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR005146; B3/B4_tRNA-bd.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR045060; Phe-tRNA-ligase_IIc_bsu.
DR InterPro; IPR020825; Phe-tRNA_synthase-like_B3/B4.
DR InterPro; IPR041616; PheRS_beta_core.
DR InterPro; IPR040659; PhetRS_B1.
DR InterPro; IPR005147; tRNA_synthase_B5-dom.
DR PANTHER; PTHR10947:SF0; PHENYLALANINE--TRNA LIGASE BETA SUBUNIT; 1.
DR PANTHER; PTHR10947; PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47; 1.
DR Pfam; PF03483; B3_4; 1.
DR Pfam; PF03484; B5; 1.
DR Pfam; PF18262; PhetRS_B1; 1.
DR Pfam; PF17759; tRNA_synthFbeta; 1.
DR SMART; SM00873; B3_4; 1.
DR SMART; SM00874; B5; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF56037; PheT/TilS domain; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 2.
DR PROSITE; PS51483; B5; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KRZ12094.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 324..402
FT /note="B5"
FT /evidence="ECO:0000259|PROSITE:PS51483"
SQ SEQUENCE 727 AA; 82423 MW; 19476DA046A7BC4E CRC64;
MKMTIGFLHL TDLSNSTVKF LIYFNIIATL LYVSAESLFV FCILFIRRAV VVILKGTVSK
STMPTITIKR RLFKDYFGDI KDEELDQLLF RFGLELDEVT TEVFSDGSGK NVEEVVLKIE
IPANRCDLLC WEGLIRALLI FYKSCEQPKY MIASSKMKPT IQLKVTKEVE TIRPYVVAAV
LRNVTFNRDA YDSFIALQEK LHQNICRKRQ LVAIGTHDLD KVKGPFVYSA KSPQEICFKP
LNEKEKFTAA QLMTHYSKDN HLRQYLHIIE HSPLFPYICD SEGAVLSMPP IINSDQSKIT
LQTKNILIEC TAVDLHRAQI VLDTIVCMFS VYCDQPYQID PVEVITPGGI RQTYPILSCR
TGKVGSEDMV LYRIPPTRHD ILHECDIIED VAIAYGYNNI KKELPPAAAI SDQLYLNKIT
EAMRKEIACA GFTEILTFSL CSRADVSMKL NQPEELNRAV EIANPKTLEF QASCFMFMHF
IARTLLLPGI LKTLAHNKDK ALPLKLFEIQ DVVERNDNSG KDPVNRRHFC AVYYGKTSGF
ETIHGLLDHF MRLLEVSSNP ALGYCIKEDL LPFYFPGRCA SIMLRGEKKI GHMGILHPSV
CRAFDLNLVC SCLELCFEDP LSRVGSFVAS TGLLPRSSLS DRPAGSSPRP YCPSGCYRPC
RPVSLVHALS VTFSHSEGRA RVQYLLANNN NDHHLTLYVN LIMTNILQRK TRYNGGIFVS
KVQFYFT
//
