ID A0A0V1HN15_9BILA Unreviewed; 4208 AA.
AC A0A0V1HN15;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN Name=DYH1B {ECO:0000313|EMBL:KRZ11926.1};
GN ORFNames=T11_9552 {ECO:0000313|EMBL:KRZ11926.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ11926.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ11926.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ11926.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ11926.1}.
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DR EMBL; JYDP01000045; KRZ11926.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR018124; Calret/calnex_CS.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00804; CALRETICULIN_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 203..653
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1125..1521
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1648..1986
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2119..2214
FT /note="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase"
FT /evidence="ECO:0000259|Pfam:PF21264"
FT DOMAIN 2565..2772
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2835..3128
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3152..3388
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3632..3741
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3774..3902
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3943..4206
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2843..2877
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3006..3096
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3325..3408
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4208 AA; 486031 MW; 48A3B7B1C37504A0 CRC64;
MKNTDLCVKL ILKIAAENFD VPLEIKTLEQ RHLNSLERFL NESNCASVVL AWSRSKSKFY
CSNALSELPE DSSCLVIIFF KDNPCVISEY NLRDHVSTVS FHQSIPDALY NTLDKVFSPV
ISNSECANDN KVSLKRLINE LQFGLQTTFN SLTYSKSEHL HKSDDDDDDD DDKSISLSEE
SNFWQRASSS GNDERAEFFH LTLQTVAEEF SKIESLQFAE MSSLLDKIQN CFNEIWMQQT
YEPFPQQRMK NLFEIISKDI YFYVKRKLGA VDFWNDSFND VFSNLRLAIS LCEQWKESCD
LLTNQIWSRW VSQKWNGKPF TSELLNLLIT RLKQIFALRS AKEILCTMLD RHQCAEIQLL
WKLPEHFHIF DLNANNDKIW HKLKFEIERN FGALARDVLS KINLLSSKSK SRSIMTYNIK
IFKILNNFLR YKDLLCLPAV KQQFATERET LLLNLSEELK NSREAFRRRS GSWIHLAFDD
MSETVSLLVR AKQEESQVEQ TMKMVSDLID DLAGHKEYME SCSDYINELQ SYRVELFDSW
CNEWIQAIDD PREFVSMQTN SQIMELSEKN GSLKVNYSDK LVRLIKETRQ LLGLKYSVPH
RIVNCVKTAQ KYYKYAETLK QVSHFYNNAE RNMLPCLQAM MLDAAVAFEK VIKVPKAGEP
KYSDSVFTVS WNDPKEVENY IMRLQEAAER ITVLNRQLQY YHQQICQKVL MLMDINLLHH
QKKWKDSLAE IREIFRDAAR LNINANNMKP WIIHWDWQLY KVLDYQYRLG LIKFSDTLSK
MKVEILFSQK KLKLKPPIEE IRSKYYREIR RFVSIPCNFK GCSDNLSFGK SIFESIVSRN
SYYIQNAYEK IEDLLEKLQI TKNSFSKWAV IGSADIETLI EEHFVEASDW ERSFRSVKQN
GREVEKIPSE IEIACITINT DSIKLFIENL LQRIYDLLLH TLRDSWQKDC SQLGHFLNEA
IRTLTSRPQS MEEITMAHVL NQNYLKKRTE IENLLAKIES KNKMFKTVAG TNLVGSDELR
QQLGKFDSML GSHRIIINDQ METLKSNVLS QIQAFSQHVE RFAVKWYHMK PKNDVSDISE
EKIHEIVDFV SQKQRELNEI VEESKRLKND AESFGLDKPR FKNLEELIHS VQACEAAWLP
YQTFYNALTE FGNEEWIFFK SKIHVFSQFL VTWSEKLKEG EMNSIAVRIQ NDVSKYRELI
PVLKYCTGES FSEDHWIELM RLMKLPTLMK HEHLTFGHFL SSTSVLVQNV SRLKELNSRA
QGEVAIRDAL HQLDLWGAAC TFHFTSQKDQ NSQQIALVTN WKEILNEIEE KQALVQSLKE
SSLQNAFYDR TNFWEERLSE LLDLVRLLQE IQRKWLSLRP VFNLGALPKE WSRFQRLDKE
FQQIMNGLAQ DNRIMMLRVN ASSKSSFTNL VEQFQRCQKA LNQYLEEKRD EFPRFYFIGD
DDLLELLGRA DNPEIIRMHL KKLFPGIHTV HFDKGNNCIT AVVSADGEIL PLQSPVKIAS
EIQSWLSALH LSMQETLKRS VILAVNTMKS GQNLDPSQFC SQVLCLSEQI RFCEQCEKAI
QSGTLDRLAA SLQSQLKTYT LVTTDSTILQ LKLKALILDL IHNLQIVNNL RKASVTSKDC
WQWQKQLRFY LENNETVIVR IVDVEYMYNY EYVGNLAKLV HTQLTDRCFL TFTQAMHMGL
GGNPYGPTGT GKTETVKTLG MLLGRLVLVF NCDEGIDLKS MGRIFVGLIK CGAWGCFDEF
NRLEEGVLSA VSMQIETIQN ALKSKQNVCI LMDKEVEINP NIAVFVTLNP AGKEYSGRRR
LPDNLKQLFR PVAMSQADNK IIAQTMLMSE GFSKALEIGQ TLTCVFDLCR EILSQQHHYD
WGLRALKTVL NTCGNLLRQN LTTLKSETST EELEMITTVH ALRINTQSKL TYSDSIIFED
IIRDAFPGVK SKEIQRNELK DSVEYAASKM DVTLSRNQKE KVFDLYEQLQ QRMGVIIVGP
SGSGKTTIWT VLKEALIKMG KQINTYTFNP KAMPKHRLLG YIDPDTREWC DGLLTHLCRK
CVSENVWSWI VCDGEIDPEW IESMNSVFDD NKLLTMASGE RIQLTKNVNF IFECDNLTNA
SPATISRMGI VYLSQESVDI KSIVKHFIEK QQTDVRENLS EWFNMYFHRA LEWILQKDEF
VAELSLVGTV KNILAIMDNV KRKKEFLVRL LYGVSRNLRH DAQTEFATKL FNWAGEKLPD
PKQPMNVVYE KSYDRFVSFD DYSDQVEVCP GTALFVKTAD ALAALSYIDM LWAKPSCKSF
IMFGPDECGK QLLLNESLQA NCSTHLVSLH CTAETNLENF LDKLKQCCTL STGTKGREFR
PKDCERLVFT LGGFYDETFE WITISNVQIV FCINISTNSK YSDLPQRFMS IMPVMSIRQA
QLNVVENECP HTEHILLTDH QARKNYPQFV LLLQLNLKVT QNDIKSLLAQ VPTCMIAIYE
QFFHLWLHES FRIFRDRLTT ENEKKQFDHL LREAVVKHWP KLLAISGKEN ILDFQLYSSC
GTETDVLKLR SQKLLDTKLI KVEEEQFYTL LKSAIARYNC EFSRLNLVIT KELMLLVTQI
ERAITSISRS SLLMIAPAGV GRRSALAITA YLHNIELIHL HITPHYGWKQ YMNDLKQALQ
TAALKNGMVI LLIEDYQLIE DRFLDPICSI LLSGEVPGIF KSEELEPLLA QLRQQAAQDS
YHGNMYSYFS ERVKQNLRIV LIIDSNELKL ATYRKHYGVL FKKCTVLSIH SWSKDSLLKI
SASTFAMITS ESSSVDIPNP FENNEIFCDR FVKVFERFSN PSPKKLIAFV GQFNKLLLNK
RSLIQARSGV AKLSEAKKVV AEMKEATEHK TNMEMLKKAS EKESEQVEEQ RKIIDAQLSK
IEPLIKQAQE DVGMIRSESL SEIRSLRAPP ETIRDILEAV LLFMGIFDCS WASMRNFLSK
SGVKEEIINF DARKVSPQTV ERVKELVARK SASFDPKTAK RASIAAAPLA SWVTANLKYA
EILAKIKPLE QQKYKLQKNL TRVERQMEKI CVGLKTSDQR VAQLRERFET LTKEATQIKF
DLDNTSECLD RAEQLISKLG SEYERWKLQM QEMESDLDQL PYLSLLAAAF ITFLSSESEE
IREKVLQELM NCADVKSFNV EEFLSTEKEL LQWKLEGLPD EAVAIQNALA IIYCNQCSLI
IDPSQRLLDW LSVHYGGSKK VEIISINDSS VFTRIELAAR FGKILVLCDM EMIDPIIYTL
LNRSLLGHET KMQLQIGEKI IDCHDEFKFC SLSETVDKSY TQQFFNRATG DSNFCIPSYA
DSLVTRINFI TTQPGLRSQL LALTIKETNS ECEAQRRQLL KNQEELKLKL QNMEELILEK
LAHLEGNILT NSDLLATLNE AKESSDRINA ALKESQNLRL EIEKEREQFM PLVQVACSLY
FVICDLHKIC SMYRFSLAFF TNLYCNVLKI NKSGTLDRLE MKRLISSLLL NTIQSIGLSL
RKRDQLIFVL QIIRSVFPNQ FDKNEWEFFI GDATEIPEER PAFEEVPDWI EENCKSRLRE
LKIMFPELIA KLNLENRIKW KDGFGGDAQK EILPSFVLNS LTPFQQLLVV QALRPDCLHT
AMIRFVEKIL GFKEWRPEPL DLKKFYLTKT SCNEPVLFVT DYGSDPSMEI ADLAKCTIGS
EQFYQVATGQ NQFELALRLL RQCAANGHWL CIKNLHLSIS WLQNLENEFK QLNPKESFRL
WLTTEPHHGF STALLERSLK VAYEAPAGLK QNLLQTWSSL DKSELLQCSL AESRSIFLLS
WFHAICQERR CYIPQGWCKF YEFNYADYKA CLHLIKKWFH KKPNGMFENV VYGGRIENEF
DMQILRAYLK QYFNKVITED NRVAIAAGQC VLPTSTSYEE YASVISHLPD YDSPDVFGLP
SNISRSWEQT ESRRNLLKLQ KLAHFDTDKT KLHTLSLVAI LKPILNLWKR LNQGVNLINA
RLLLSNLKKN NRTPVETFAV SEYNAAISLV QFVHAELSML HKSTLNFHSH NLNTQLLSTL
LAKNEIPNEW LHRWPTGPKQ ATEFLSRLIT KAKALQQWVQ QLNSDTLTNG VVDISMFFRP
ETFFNALRQQ TARFQNSSIT SYAMQLSWNE ISSSLSPCTI TGLCIEGAQF DGKYLTDATA
DASPILILPP ANVLWTKNDK NVTRSESVKI PLYHDSSRSH LILSVDLPCK SSDAQKWLVR
GVAMFLKN
//
