ID A0A0V1HNH2_9BILA Unreviewed; 567 AA.
AC A0A0V1HNH2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
DE Flags: Fragment;
GN Name=Hexb {ECO:0000313|EMBL:KRZ12001.1};
GN ORFNames=T11_2118 {ECO:0000313|EMBL:KRZ12001.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ12001.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ12001.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ12001.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ12001.1}.
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DR EMBL; JYDP01000044; KRZ12001.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HNH2; -.
DR STRING; 268475.A0A0V1HNH2; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001093-2};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 66..180
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 205..526
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 361
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
FT DISULFID 95..137
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
FT DISULFID 314..366
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
FT DISULFID 543..561
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ12001.1"
SQ SEQUENCE 567 AA; 65199 MW; 60C01D484AF2AD09 CRC64;
LHMPLRQVIA AYETIRYCSF PPGVIKQSKT GIIMRLSTLY FIVLLNTGFV KLSISKFISS
RTYGIPWPMP HEFTLDNGNF SLLQESFKFY TTYSCDILAN AMQFYLKILF PPSDSSTDET
SELLPFTTLK IVVHMPCPPG YPTSNMIENY TLSLWPNGTG LLESLQVWGA LRGLETFSQL
VIPADPVEHT TTMLRSANIN DSPRFPHRGI LLDTSRHFIP VDVIKTQLEL MAQNKFNVFH
WHIVDDPSFP YQSDSFPNLS NKGAFSNQRI YKKLDILKVI NYARLWGIRV IAEFDTPCHV
QSWADAMENL TSSCDISHLY FDPLTGSLDP TRPETYSFMK TLLQEVLNDF PDEHFHLGGD
ECDLGCWDYN SAIRTFKKEM NFTTLKEVQS YYLNKLLDLV MEIRPNLIPI LWEDGLSDSI
KYSDKLIIQM WLGNTRNQQR SRLANITARG YRALVSSCWY LNIIKYGIDW PEYYDCDPRD
FNGTLEQKSL VLGGEACMWG EHVDSSNLTP RLWPRAAAVG ERLWSMEMKR NESTAQRLEN
HRCRLLARGY TVEPVNGPGY CYEVAKL
//
