ID A0A0V1HQK1_9BILA Unreviewed; 486 AA.
AC A0A0V1HQK1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 25.
DE SubName: Full=DNA cross-link repair 1A protein {ECO:0000313|EMBL:KRZ12468.1};
GN Name=DCLRE1A {ECO:0000313|EMBL:KRZ12468.1};
GN ORFNames=T11_4400 {ECO:0000313|EMBL:KRZ12468.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ12468.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ12468.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ12468.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ12468.1}.
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DR EMBL; JYDP01000040; KRZ12468.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HQK1; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 369..469
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 53..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55608 MW; 82A548747A4CB8DD CRC64;
MDFDVWNYES VKTRLRKRKI LEEVLCPLTT TSPVRMNKNE RKASQQSLTK FFKRENGDQS
NKHSFNENHS VEEADSFSSV SSVRPLAKEK PKKLSRTRRH SSSSGQTTIT EFFKFPNGKG
KAVETVKVTN KKQASSTSAS SANVKHKFRR CPMYKFVPGT SFVVDAFNFG KIPDIELYFL
SHFHYDHYVG LTRHFDAPIC CSQITASLVH LKLKVSKSFL RVLSVNEWTD LGDDNSVMLI
DANHCPGAVM FLFHLKNDHY VLHTGDFRAE QVVLDNPIWS SIRVDYLYLD TTYFNPVYIF
PCQMVAITKM ISIVKQIQQQ HNKLLILVGT YQVGKERIFT ALAEALDCKV AVEKNKMQTL
KCFDDKKLSD SLTLLKSSTF LHVVPMSFLN RQKLTAYLAS YPTYEHLVAI KPTGWEFSGR
TEDSLIDIQK MNKITILGVP YSEHSSFDEL KQFVLKLRPK QVVPTVNVSA RAEINRVIGQ
WLNESS
//
