ID A0A0V1HS18_9BILA Unreviewed; 2097 AA.
AC A0A0V1HS18;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ATP9B {ECO:0000313|EMBL:KRZ13321.1};
GN ORFNames=T11_1975 {ECO:0000313|EMBL:KRZ13321.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ13321.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ13321.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ13321.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ13321.1}.
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DR EMBL; JYDP01000033; KRZ13321.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 9.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 9.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2097
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006879395"
FT TRANSMEM 1385..1411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1655..1679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..311
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 318..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 418..512
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 516..606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 611..726
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 730..832
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 834..931
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 934..1026
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1031..1124
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1126..1228
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1519..1794
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1714..1785
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1826..2085
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2003..2076
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 398..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..674
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2097 AA; 235900 MW; E0ABB0F6D2995CBA CRC64;
MSLLVLCLML IVGLVATDPD VDDDLFLTKP QDSVVLLNSK IGFICEVKSS DQLVKIEWLR
NGNSVHPARY MVEAVDDTTS ALLIEPVRER DNNTEIGCAL LDADDGQLLA KSTARLGVVD
AQHLAPGFPK VVEGPKLRTV EKGGSATLTC RVVGDPKPSI LWLRNALPVN MTNRRYSIST
LGNPGSLVIQ NADESDEGRY ECVARNRNGV THSQSAHLYV KVRVFPPFFS RRPESRYQVM
PGGSVNLSCV AVGHPMPRVF WRRGSGEDLE DAFKAPYGRN VLTLTAVDKT ENYSCVAFSS
LGNIESSTTV EVKALAYPPS NLRVLKQNSN SVELAWDPVI AAPDNNIVLY YLIEYRPKYA
DLSDFFTLKV VNQTETNVTN LQPYTQYEFH VRSVTAVGHS RPSRPVETTT HEAPPQGPPK
NVHSRAVSVS SIMVQWEPPE KPNGFIVAYM VYYTSQPTEP FSVWSTKEVG NERLTTVGDL
QPNVVYTVRV QARNSAGFGP VSEPVSVVTQ PGIPGQPQNV KATAIGARRI LLTWESPLFS
SDITGYVLRY NSTLTDHVEE EVGGSKTERV VENLTPNTDY SFQVYAKSQR GKGLFSRAVR
QRTNPSVPSG APESVVVEAL SSRQLRVIWE PPLKSQQNGL ITGYRINWEP LINADDDADG
DDDDDDDDND DDDSAVGTLE HSAEKQRSVV IDKLMPYTDY QITVAARTVK GYGPPSEPAI
ARTHDDVPGA PLNLKVTPLN ASSAHVAWQE PINKNGILVG YSVHIEELDH LGLPLHSGMM
FPAHRVASDK NETVVHDLIP NTNYSFRVNA YNRKGDGLFT KALVVSMPSL PPSEPRDLSV
ELIQREMPVK LLLKWNEPEK TYAKPVLRYR IRYGMLDNFN NTVETQFTNL TSLILKNLKN
GRSYEFAVAA ENKQGFGLSK KLVVTTPTAA PSGPPYDVRY EIDPSAKRLQ FSWEPPLLDE
RNGEITGYET RLSIPSRNDI VREIHESTVS FLMGEVGVRY GFAVRAKNSR GYGPWSEPVT
VETQSDLSQM EVKNVTVQAM STTSALVVWK PVNERRVRGY KVLYTAEPSD RAWRDKEILN
PAADRLLIED LMPKVHYAFC VKTILIDGAV TECSENAFEV IQPKYVVHDV NVEKLHSSFV
QLRWEYDGPR PASFYVKYRG KKRYKTQIDE WKELSIDGLT TETEQQVLNV TNLRPYTNYT
FDVGVVWLND THQHYYLPQT VDIVTKKSVP PFITAPVVLE SLNSKEVLLR LEAATEEYGP
VSYYWLVVVP AEFPRIPDKI ENKEVLHAKT YHPMPGDLYV AARLTRREIL AMKGGLFTLG
DGLRYADFTN FPLNNKIHYK TFLRAFLDDE AESDFNEPSQ TSSMYSAEFS PLTMIAGPKV
SGSSLWIVGP IIALIVVGFI IGIVCFFVFS LNKKNKLPTK QGSVNKVTLG PVGPTETSRL
LKDAHGNTTV VNGPAVNAYS SKMPNMYCGA GAGDQMEMQS VFYPQPPPTV ASASPHSPIP
VIEFAAHIDH LKANDNLMFS REYESIETGQ QQTWDHSNFD YNKPKNRYAN VVAYDHSRVV
LSKLADIAGS DYINANYIDG YHRSKAYIAT QGPMPETFND FWRMVWEENS ATVVMLTKLE
ERTRIKCDQY WPSRGSALYG LVNVAMKDTT ELAHYTLRVF QISLVIILRS YFTILRLLIN
LLSKQGQSEV REVRHLQFTA WPDHGVPEHP TPFLIFLKRV KAVNPAESGP VIVHCSAGVG
RTGAYIVVDT MLDRLRYENT IDIYGCVTAI RSQRNYMVQT EEQYVFIHDA VLDAVQSGCT
EVPVSKLFLH IENLLQYQAM ENATGMELEF RHLSTLKFPN AKFTAANRPC NKLKNRLVNV
VPYDWSRVCL TPLPHADGSD YINASFVDGY RLRKMYIATQ GPMTNTVNDF WRMLWEHNST
IIVMLTKLRE LGREKCCQYW PSDQAEKYDY LLVEPIAEYN MPQYVLREFK LTDSRNGQSK
TIRHFQYTEW PEQGVPKSSD FLIDFIGQVH KTREQFGQEG PITVHCSTGV SRTGVFIALS
ILLERIRFEC VVDIFTVVKL LRAQRPNMVQ SEDQYKFLHQ AAMEYLGSFD HFALPQF
//
