ID A0A0V1HV67_9BILA Unreviewed; 1513 AA.
AC A0A0V1HV67;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Merlin {ECO:0000313|EMBL:KRZ14256.1};
GN Name=NF2 {ECO:0000313|EMBL:KRZ14256.1};
GN ORFNames=T11_3007 {ECO:0000313|EMBL:KRZ14256.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ14256.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ14256.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ14256.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC5 family.
CC {ECO:0000256|ARBA:ARBA00008044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ14256.1}.
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DR EMBL; JYDP01000026; KRZ14256.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 3.30.70.100; -; 2.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR012577; NIPSNAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR019163; THO_Thoc5.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF39; MOESIN_EZRIN_RADIXIN HOMOLOG 2; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF09766; FmiP_Thoc5; 1.
DR Pfam; PF07978; NIPSNAP; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF54909; Dimeric alpha+beta barrel; 2.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 28..320
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 325..454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 525..559
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 761..791
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1513 AA; 175513 MW; B1B4F9EB04FC3525 CRC64;
MPANFSKVGN TWSVNDGKKR SKASDECLSV RVTTMDADLE FSVPKKITGR ELFELVCRTI
GLRETWYFGL QFINKKGYFG WISFDLRITS QDIKKAENGY HFYFLAKFFP EDVSEELIQI
ITQHLFFLQV KQSILNMDIY CPPEASVLLA SYAVQAKYGD YCDVNIDICE LALEELLPQR
VLDQYQMTCE MWEDKIKTWW MNNRRMTKEE AELEYLRIAQ DLDMYGMQYF PINNRKESNL
WLGVGPLGLN VYEKNNKLIP KASFTWSEIR NIAYKEKKFL IRTLDKNSVA TVSFTSQNVA
VNKVILDLCI GNHSLYLRRR QPDTLEAEKQ KLEKEQERRV QAEKERDRMQ QELTKLKEQI
SAAQEALKRS EETADLLAEK AQISEEEAFV LTKRAADAEA EIQRMRIAAI RNEEEKYSME
RKAREAELIA ARMVEESESR TREAQKLKND LMRAYNAEQL AKSKLREVMT SPFSPMPLTN
NFEFPTGQDR VHLACSPISD HCIFSGMASS HTDPVGAERD IKSLSAEIEK ERVEYLKKSK
HLQEQLSELR SEIEGLKVEE QQTDLDRAYQ ESLQLGDDKY TTLRKKTMAL PDQEQDSQSE
KNDVQIFFEK EDQDACSVDA SAFTAQFHQI IEHLLMQMST DKSTLSIDEV QENNLISVAL
LKQLNRLFQY KNSILKEELQ KVIKEVEQKF AKLQNAQQEV SLIVKEKEHH LNFSSDDQKI
ALIPLEQFFS EACTDESKKE LNEKCPQELH TARLAWELET RKRLGEEIKQ LEELNKKMIA
ENSALKKKLD EFNPLLLSVI KAVRPLQELV GWDSTNDTLF QERLQHLPRP LFFIFMEIIA
FNDIYDEKIS VSIKGDLAKL AVNLSRSSSL QDVSEMEADT TDGDILTSVG NQLDESRVEE
EKRMQENLRE YHLSVHPLSV QLEITLDNGC VLLLKLQYLT RLKLLSVHTN VQLPNEASAA
RFSHFLFNES LLDFLFPNDS GTTCPDVAMA AKLQYYKIDI AEEIETVGRM YFWLQRLGNL
MPVTQQRSDV TVMRTDLNLS DLNISDSLDF LFTVVAAMKR RMRIRFSLLQ QLISMWSLEL
KYPDSVASWS SVASAVEFLS WRCATFADFQ NHEATKRQCE NKLINNNDWF FKASFKLQTL
QLEVLLAVSC KYPDVAPKLF FCFSKNSDKY TSFNNEIVRA MERHVNFVCI KKIPPEYKDE
ILSVQFKCVP ILMHLALHLN FGIDENRDSL IDNLLPNMHR GRDREPPLTC VDQFISSLRA
NLFRTFPDAA LNCRLFFNFF GKSNKKETSG GHSSLISDKN YVYEISYHNV QPGKMESYLK
NYENYSKLLE HKSSAQLLGS WSTVYGTEDQ AIHLWRFTNG YAGVDETFQL RVRDKEIRLL
SDEFAKQCQQ RSSSLALSFA FWGEPQPRCS ENLYEIRTYI LKAGTMLEWA KNWEKAINYR
RKENQNVAGF FAQVGRLCKV THIWAYKSLE NRRILREDSW RAPGWDMHVA YTVPLVVKME
SNILIPTAFS KMQ
//
