ID A0A0V1HXE4_9BILA Unreviewed; 1960 AA.
AC A0A0V1HXE4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein MCM10 homolog {ECO:0000256|ARBA:ARBA00017770};
DE Flags: Fragment;
GN ORFNames=T11_778 {ECO:0000313|EMBL:KRZ15403.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ15403.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ15403.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ15403.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM10 family.
CC {ECO:0000256|ARBA:ARBA00009679}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ15403.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDP01000018; KRZ15403.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR040184; Mcm10.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR015411; Rep_factor_Mcm10_C.
DR InterPro; IPR015408; Znf_Mcm10/DnaG.
DR PANTHER; PTHR13454; PROTEIN MCM10 HOMOLOG; 1.
DR PANTHER; PTHR13454:SF11; PROTEIN MCM10 HOMOLOG; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF09332; Mcm10; 1.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF09329; zf-primase; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM01280; Mcm10; 1.
DR SMART; SM00539; NIDO; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS51220; NIDO; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 912..1054
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 1119..1161
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1288..1327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1328..1369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1374..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1417..1455
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1657..1697
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1698..1740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 143..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1752..1846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 623..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 154..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1761..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1130..1147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1339..1356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1960
FT /evidence="ECO:0000313|EMBL:KRZ15403.1"
SQ SEQUENCE 1960 AA; 219539 MW; 9D2DDF4F1C1E3FBB CRC64;
MDDLKDESLD ILVDLLNTNF DEEFDDNRCP SPDVLLTENS ERKDNDIDLD EFLRELENEL
ESDPFDISSE LPGGNCNGNE NSLSTLSEDD LNAKARDIFR ELQRRKLRRL NYSVGSGVQR
EKAVHSVLCE NFDFTKPTSV KVKNSSVIHS GDTSSSEDEA KRDPEADGNN WLSDEGRLIK
YQLTEMESYQ MNHPKSKADN YKYQPSSSSA SRISSNSSVF DRFFRIKIKN PKMSLATFTH
IIGSRPKFQL AAINNSKRID WSNWVTMAVI VEKTDQRRSS QGNLYMIWKL CDLIDCQRIV
SAFLFGSCLK DHWKLPVGTV VALFNASLFK SDTSVQAKDN ALKLETAGKV LELGYSEDFG
ICKSKQNKTG NPCNNVVNKS KSEYCDFHIL NVSRQFTSKR SEFYTPSGHP RLKKDNKLLP
PKDCSNLKKS KPSSSESKLI VDELSAAKLC QELKMQNALN SLKSLPSNIK GKSSLYKKME
KDDEFAFLNL LKKHEIVDQT VSVIQDENKL PLKAANACEK NKWKLSCKEF LKAYEPTTTV
KNSVPLPKIG KGTSSGCINL EDAKMKLTKQ KAIEIVRSAG GIKKQDPNRP TSGYCILEKR
SAETTTKIKD NATVSKRSRL GEKNFTIDEM RQLLKQKSRF ENELRNDEAE KQAKYFEIME
VKEKFDRHAE QVFELKNCQV VSCKTCNYTW HAQSDLCKSQ RHEILRHTAT KRFFRCLNCK
KRTISYSLYP SRPCHQCRSR NFERVAMKQE RRGPKLPAEE LKIRGEELPF VNSAAQHTLP
AFMKSANHIW FLAALVLLCQ TILSSEDANG IRPRRRRQDQ SPNLGAPMHI DLNITVPFIF
KPRLYPYGEG TGDNELSSWT SVQGYVLQNE ISYWGESFAS VYISKDGVIG FSPNFAESKP
IAFPAGEKVL AIFWTPSSLG DIGKVYFRET TDPQILSLAA SEVQLQYNYD SSFTPSSVFI
VTWENLAPPM ASNDLPDSHR NLFQAALIMS ENGSFAHIIY SKLKWHGNAI VGFNNGDGIE
HLTLPWSGSS DVLKVGAESD IGIPGEWMFK LDESSGVHLC GKGYKGIDCT RTCSKNEFSY
DCHRKCHCEN GLLCNEITGI CPTERCEKGW TNAPTCDQDI DECAMQTKLC NTQAQPDCVN
TPGSYNCTCL VGYDAVTNTC SGVSTGLSHV PEQTDSVQSQ LTNAMLSAFK PKVQSDVILK
PQKTSEFVLN PFMPAPLRGI FEETKILTAQ REDLSGSGPN FWSLTSSNRP QVTCRLSCAE
NSKCQFVNDT EKCVCNKGWT GDGVYCVDVN ECLTENLCPS NSKCLNTVGS YDCICEKGFR
FNGQDCIDID ECAEGTAICQ GGAASTCINT NGSYECHCKT GFNGNPNSPA GCIDINECLI
PKFYCGPNAE CENSVGSYMC RCLPGYLPKQ DGIGCEDIDE CENHPCSAKA TCINSPGSFA
CKCDATYYGN GFHCEKSRLF PYSRAQSDSI FNYNQGSVFI NLKRLVRILG YNYDKMRVFT
TGMIAFGNPP SVNNIDRMYA SSIMPFHYDL GFDKNGTVYV EQVVSGPLLK ELADFVRESY
NLKDDALTYQ AVLASFDYQT FAIFIYDSVI PVAAQIGAKN NGNDNIGIML PFRGDDIFNL
VNKSNIGISG KWMFRIEDMQ VEPCRQGYEE PPFCSKDVDE CKAEQPPCHK DAICVNTPGS
YLCKCKHGFT GNGVNCFEIN PCYASTGSVC GQNAECYVPS FKGGKPECVC KEGFVGDGFS
CFPMPATNEV TLEPETESPK IEKTTTLTQT STSTTEYPMT IRLRSRRPIT FGPPTPVTSF
NSEQASTREV SRPQTPTSVQ IRPLQKEPRT NTQTEDPNFP LSSASISPEE IQSLSSVYFS
SDSNRTSCAK RYLARPSRCA NGKEESVWNQ FINRRRLRDF TTERQILQDL AVCTKFTGPT
LDTISQHFHQ PHIQRHTQRI LHFIPFLHIN MAVIENIVQL
//
