ID   A0A0V1HYV0_9BILA        Unreviewed;      1242 AA.
AC   A0A0V1HYV0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KRZ15741.1};
GN   Name=Pnpla7 {ECO:0000313|EMBL:KRZ15741.1};
GN   ORFNames=T11_14623 {ECO:0000313|EMBL:KRZ15741.1};
OS   Trichinella zimbabwensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ15741.1, ECO:0000313|Proteomes:UP000055024};
RN   [1] {ECO:0000313|EMBL:KRZ15741.1, ECO:0000313|Proteomes:UP000055024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ15741.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ15741.1}.
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DR   EMBL; JYDP01000016; KRZ15741.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1HYV0; -.
DR   Proteomes; UP000055024; Unassembled WGS sequence.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 3.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   Pfam; PF00027; cNMP_binding; 3.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 3.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 3.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          172..239
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          383..488
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          494..595
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          843..1009
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   1242 AA;  141339 MW;  05256A3B2313E597 CRC64;
     MVSGLYYVLV EILTKDGCVH AIHSATLRDS AVDLHYFKLC NYFQVIRQFF NNFFSFPNQL
     YSASSATKYP VTFSRKSSFN YRFRKRDRML FYGRKLMRKV TSAVINGDKK QKLRKRDRVF
     RFASKFLRPQ KKDFTARPIR RPPDAFLEAD TTSLPVSPKS IQLLNMLKSI RILGHFEIPF
     FLDVCKHIET KRFASDQFVF KDGEIHDCIY IVESGRLSLF IKDEKFDFEV KSVGRGDSLY
     CSLSILDMIK NQARPMKNVF AKATEESVVL QLKSSVFNDI FDKYPESWTR TVQIILLRFQ
     RITLATLYRY FGFTSELSKT GIRTVSKLSP LQEQPCKDFR EIKSENEGAA PEDCPTSENV
     IPTFVASTTD DDSDIFQVAI EELAKLFGMK EASFLVDKVK VENFEPGVMI VRQGSNELQL
     FYVVSGLLEL LLESQEEPDV LLPISIVQTG DVVGGLSVLT GEPSFFAVRT RSFCQLAIVE
     RKSLYEIISE YPRVVVNVAS AAVESYSDFV KEFDMAVDWE ICESGKALYK QNEQADALYV
     VLSGRLRSVL TREPGTREVL NEHGRGDVVG LVEIWTLRRR STSVIAIRDT ELCKIYATLM
     NFIKSKHPQV LSNIIRLLGR CIIEQQQQTI SAVHREPLAH VSNLNTIAVI AVSDEVPLTG
     FTVELWNALN SITPTELFSS YTLQDMLGPT ALDKVNEYQI ITWLNQQEDG NSIVLYQCDV
     ELTTFTSLCI RRADCILIVA NGEQEPMVGE IEKELENLTV RAQKELILLW HDSTDRPRRT
     AEWLDLHGWV SSHYHVRFRD RVFKQRNPKR MLRYKERIIR RYDNRYTDIA RLARALTSTS
     IGIVLGGGGA RGAAHVGIIK ALKDHGIPVD IVAGVSIGAF VGGMYCLDSD VPKLIMCAKQ
     AFKEAASFWA RLFDLTYPVS ALFTGKALNR LLKSVFNDVE IEDLWIPYFN VTTDITSSEM
     RVHRSGKLWR FTRASMSYIG ILPPLCDPID GHYLVDGCYM NNLPGTLWRY CRASMSLAGF
     VPPIFDLTDE HLLLDGGYVN NLPADVMRSL GVRTVIAVDV GALTETEFTN YGDSLSGWWA
     LWKKYNPWAS PVRVMSMAEI QSRLAYVSCV RQLEEVKKAP YCHYVRPPID KYQTFDFNLF
     DEIFNVGYWH GKTLFEEWKS SGKLQEVFDG RSANISKFAQ RDKFKQGFAF TSAQSFTDLA
     AMVSKIHRPF ETSLDEISEE EGDDRIPLDL AHTAGSSSAK MV
//