ID A0A0V1I090_9BILA Unreviewed; 993 AA.
AC A0A0V1I090;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|EMBL:KRZ16285.1};
GN Name=SLC12A4 {ECO:0000313|EMBL:KRZ16285.1};
GN ORFNames=T11_18140 {ECO:0000313|EMBL:KRZ16285.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ16285.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ16285.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ16285.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ16285.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDP01000012; KRZ16285.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1I090; -.
DR STRING; 268475.A0A0V1I090; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF53; K+_CL-COTRANSPORTER; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..241
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 333..624
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 773..993
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 881..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 111407 MW; 28BBD33786AD13CD CRC64;
MGSSNDSSNP DETSAVGKVS DIMHVCKSSQ NSRCVPVGEY VQKNEAILEN RFKKSAKLGT
MLGVFLPTIQ NIFGVIMFIR LHWIVGMAGL IQSLIIVSMC SCLTFLTSIS LSAIATNGVF
EEGGPYFVIS RNLSPEFGAA IGILFFLANA VATAMYVVGH VEVFLTYVAQ DLPQFGTALL
RTDEEMANNF RIYGTILLLI IVCIAACGVK VTQTFAPISL FCVIISIIGI YTGSFVYNTT
DSERICMVGE KAIKRLPLIT NGTLDSSCTK EENGTLWNLY CRVYSSENGT TCDPYFLNHN
VTLRIVRHGM LSQHYKNNLH SYYMKAGEAA PGEKGISGVE VTQDITSTFY TLLAIYFPAV
TGIMTGCNLS GDLADPQHSI PIGTIAAQLT TSFVFISYTL FYGMSIDRAL LMDKYGESLG
GSLVSGQLSW PTEWLVVVGC MASTFGAGLQ SLFSAARLIQ AVAKDNLVAK LQSFGKVTSK
NEPCRALLLS AFIAELTILV GAVDHIAPIV DFFFLICYCF INIACTLQTL LKMPNWRPRF
KYYHWTLSLL GAILGFFIMF STHFDYAVIV LIMCFCIYKY VEYHGEKKEW GHGTEGFRFT
TAHYVLTKLE DKDMHPKNWR PHVLLFMKPD KTKEEIMKDP ALLFAAALEE GGGFLMLTTF
IEMKGENNSM NQLISTETTK LKDVLKTMKI KAYVRVIPCK DVAEAVWIHT LGAGIGGLRP
NIIITDWPHR LKTWKMTNVK YWDFLYSIFY RCTASKSLII PKGHIPSLNE ILSGNIDVWW
LAHDGGMQVM LTVLLKKHRI WKNCKVRIYA VANHGENLTK VHEKLKKWVY NLRIDAKVEV
VEIPLFKYDQ NDEVKKFLST RRKLAAELGL EEGFMNEKKV KAETDQELDT KDSENQTASG
NSEESTISYD EAIKDENVTW KTIEKRFLLS VYLNELMRRE SGESRLLIIN LPEPPSNKQF
MPIYLDYVDT LTTKLKAVIL VRGTEKDVIT IFS
//
