ID A0A0V1I0S6_9BILA Unreviewed; 1739 AA.
AC A0A0V1I0S6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Protein HIRA {ECO:0000313|EMBL:KRZ16023.1};
GN Name=HIRA {ECO:0000313|EMBL:KRZ16023.1};
GN ORFNames=T11_10901 {ECO:0000313|EMBL:KRZ16023.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ16023.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ16023.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ16023.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ16023.1}.
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DR EMBL; JYDP01000014; KRZ16023.1; -; Genomic_DNA.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.10.290.20; Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 15..396
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REPEAT 622..653
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 678..713
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 721..753
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1251..1443
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 1037..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1739 AA; 193775 MW; 55209F6877E1EB9B CRC64;
MMGENEEFLD MYHSFTSKKL LVVGAGGIGC ELLKTLVLSG FADIEVIDMD TIEVTNLNRQ
FLFRKEHVGL SKAKVAVESV SILNPNVKLV YYCKPIQSRE FNVNYFKKFT AVLNCLDNIE
ARSHVNRMCL ICHLPLIDGG SLGRKGQVDV IIRNITECFD CHKHSPSHDY PSCTIRNTPT
EPAHCVIWAQ HLFNQLFGEI NSDQDVSPES LVTGEEFEAT PQVKPLTNVI SLQDLAKNHN
YDPEVIIKKL FVNDIEYLRT MEKLWEDRQP PTPLNLRWFR IGLDENLQGT EEKDWESRDQ
NVWTLKECFK VAVSCLAQLK ERAENAPLIW QKDDPVCVDF VTAFTNFRCH VFNIEKIPRF
EAETIAGRVV PAIVSTNAVV AGLMVLKLYA VLERRKDFYG SVAISSQEGM PRFLSIAPST
EITGCEYCVA VKEVEVSLNV SSFTVENLGK IAKELSVMKP EIMLEVASPR LLFAHDFKLS
AEEGKKTLSE ISVKHGSLLR CEDGATFSDI RIIISDCPEI YDSEENCRRN LFIKVLVGSN
VVIYRFTAHV IFNCIQLIGN EVNKAELGLP IYSVDIEPAG NRFATGGQSA TGIGLIVLWS
LKPVIEVENE TDDKIPLLLC RLEAHSTCIN CIRWSSDSRY LASAGTDQAV KIWRFVSYIP
NVKSRVTAVE HWKCVSTLHG HAGDVLHLSW SPGDRYLASC GIDNIIIIWD AKNFPEKITS
LVGHEGFVKG VCWDPIGKYL ASQSDDRSLR IWSTVDWSVV HKFRRPFKEA PCATHTLRLD
WSPDGLLLAT AHAVNNGGPV SKIIERNGWK CELDFAGHRM AITCVRWSSV LYHRNRKVLL
TEKSNVCGCC AVGSKDRSLS VWSASENRPV VVLTDIFESS ISDISWDSSG LILIAASVDG
SVVCLVWTTD ELGVPLSLDE KINELRRYYG NVDVGLLGLQ RKSDQNSNKI IEDADYVMTH
AKIWNVQLET RTKSGKRRIT PINVEVVAEV DTDNNSQPPW IREASFGVVG QAKGLIGQKV
TVVDSAERWS GLNSSIVEPL VPSSSSSSSS KSSSSSSSSS SSSVKSRKDN SFDASGKSIL
KSSEDPSGGI VEEFLEKSKS ELKFDENKSW HQKGKKASKP ARRESTISPT FPSSETEVEL
QTDPQTDQTS AVNSSSKQKI PIDQLEALKV VQLLMCNVVV DESGSEMLLQ LSNNIDSKPK
GKFAELLCMK NLNCVWKILL ETGAVALKAN RHLILVVFEN GMFDILSPLD GRMMCLTNVL
GDSVNYVDLD GKLIALVTVC AELYVWTFVK SLELVCHVSL KTLLRDPKRK LSRIAFSAVG
MPIICFNDGS LFSYNASSKI WQKLLNPSDS FIKYSPTSIL ASAKAYLTTK GRFQNLCKNL
FSVTFTAESD SEMQERIREG FLERFCLASR AVGSEHEYMY WLSEYVKLLV KSESEVKLRC
LFRLLVESDE HMEMNSMLNR DKSEKRSAVT DLLPLVAANP KLQRLYSELS FLVAKKSSSE
QADDLYSEIA ATTINSLKLS CDKMSVEKFL KSAAEEKSSH MSMVVILLNK LNKRCVGYVL
KSEQDSSSGS RFILTTRTCS AKQGNAAIYL LPENKERRVK AIHTRGFHES LAVIEMQDKY
PFKLAAESTC QLESSKISEQ CFTVYAVEKQ VNKRDIVAEP YKSSPKSSCE KLWITFNEES
FACAATSQAE KRNGLGLVCS QGGKLALVGI SSENQQAAGV ASFTLLSPYA KQLEALITS
//
