ID   A0A0V1I3R0_9BILA        Unreviewed;      3589 AA.
AC   A0A0V1I3R0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000313|EMBL:KRZ17563.1};
GN   Name=prkdc {ECO:0000313|EMBL:KRZ17563.1};
GN   ORFNames=T11_17542 {ECO:0000313|EMBL:KRZ17563.1};
OS   Trichinella zimbabwensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ17563.1, ECO:0000313|Proteomes:UP000055024};
RN   [1] {ECO:0000313|EMBL:KRZ17563.1, ECO:0000313|Proteomes:UP000055024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ17563.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ17563.1}.
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DR   EMBL; JYDP01000006; KRZ17563.1; -; Genomic_DNA.
DR   Proteomes; UP000055024; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR046804; DNA-PKcs_N.
DR   InterPro; IPR046803; DNAPKcs_CC1-2.
DR   InterPro; IPR012582; DNAPKcs_CC3.
DR   InterPro; IPR045581; DNAPKcs_CC5.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR   Pfam; PF20500; DNA-PKcs_N; 1.
DR   Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR   Pfam; PF08163; DNAPKcs_CC3; 1.
DR   Pfam; PF19704; DNAPKcs_CC5; 2.
DR   SMART; SM01344; NUC194; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:KRZ17563.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW   Transferase {ECO:0000313|EMBL:KRZ17563.1}.
FT   DOMAIN          1767..2138
FT                   /note="DNA-dependent protein kinase catalytic subunit CC3"
FT                   /evidence="ECO:0000259|SMART:SM01344"
SQ   SEQUENCE   3589 AA;  411040 MW;  0AF549BC8978E67C CRC64;
     MAYSTVDRIR DALNSLKDFI EGADSDQAED CVQQISHHFH KLSGSERNFG FCFNSLLSND
     SNSLLSILSS SIGKTAFAQT IGYGIEIIRL AIAKTTSLSP SHRKAIMRFT LRLLKLDYLK
     GRREVVLYLA NECIKYSSVL STESEELNFC YDELLHCCLA LIDSLKKLQN GVKKGLFIII
     GSLCQEIPEK LITADYNYAL LFANIMSEEL KNQMCSSIHS PSYSVIEGCF LGLNDLLAHF
     SNLFDGACRM SCSELFNLIK KACNPKNDVH RLGHLKAALS LFISRVQFFR HHFLDEYSLL
     NECFSHWAKH YDREIKTYSL NAEDLLIREL ATELITKVNS DPNHVRSVYK YFCNQFDEVF
     SNTSGIREIS MISKSYGRLF QIGKALYGEE EVCKVLRKLL QRFEYLSTTS SDAQQQKVYH
     ITNILEAASR GLICLSKIAD DVWQLVERFH VTLFHNFPLM EKRFYHRCKV INFATFAAAY
     GHNYQYIQSI VFQSLIRVIA SLPSVGKESI VLTKDENTFH LADYLPFWKM LLDSEFVDLS
     EFGFDRTMQV NIQRTFFDCF MKSFLEIVRL LSFETKAFQD VEEYTFRFSN PILNVIPTKQ
     ADYDLFYNLV ELCRSVIMNG SHVLFEPWLQ PMLTMLLELS SRYPMVSGFY KLLAVWVTMA
     EKLNYFNSTE QDKTENCNSH YKLLLSDFID HVLVESCRFQ GELLVSCLRF LLALPTCIVV
     EKLESIKEAI KSSLKLGLNY LPIACVCLDA LEKWSAEFPE DEPQLDSFYT DLLPIFDDYL
     RCTSVDETLV VNNGFNYNGE KSTFFNRKLR PVNTDSENVL DKGDDNDSEE EMPNPQTVLR
     RIASFVGSLG CYMNRFLIDS ADVGSLLRWG QGSHLEFICP FPDMKFEIAL DTLLPRLCDL
     ALSAGDRPLK VAACEALHAC VLFLLGNESF RTVKMKDRES ISKAYSHLFP VLLKLACDVD
     EVPKQMFSTL FVQILHLFSG TDFADKMVTS CLLDTLMDGL CCFWNSSLRD QSAYYISEYC
     RWSMRRVDSG GQNMRSESKV ELLVQTIITF AVHSSAVKRA GAAVAFNNLY KIIREKRWLV
     DIYILEMFFT FMKSLYLAEN DDELYGTVDE CKQAIKHIRR IILHNLDMLQ IHNEQRRTPN
     EWSQSTVHCC CDWLLNTMTW SNCQFRSECF ISYQELTNAG SEIEKLHFLR HIGTSIFGFI
     DHFERSHRSV LGSFSICNLQ DRVVAGTSIY ALVLWLETYE AMIDGYVWAL NTNRISMEAW
     NDYLLNEDPR VKSLLFPCSL DLVNSIVIGR HFPNLSKAQR NRLNKTRCKS FVALCKLIAA
     LISCQNLNNF QGFLKLLLYP NTWNAFLKVA CDPKSLGFRL YSKQLFECIS QDVRLLFLAL
     KNNTFLVQQV STSMKEYLTQ FYPWPDVESV VTCDSHLAIE QQQLLNVYGM LVEVGLQSVV
     ELPRAEFLWT TVADVYFSKR IGLPPSKLGM VKQIFRVAAL TGSAVDVLIK LLMNTESVRL
     AECSSLCSTK GELLIANFSD EIALLLCTNV ELFLKHLKEA SRCQPDVVGR TLLQTVTVVV
     HSSDLRKNYG RELALQILQI FGQELLYWAD VAVSNETLKL LWLKLIMKLI LIDSKITEWP
     EFAPMASAYF MMLNDQSLTL DFKNRMLSLL AGFCTFDKHA CELGRSLKLF MVNNFPLKSD
     EFAKGTAKYD QYVAACQKIL FAFGCTGSPV ILELLLSMIC REQSHPIASD LKHQLQKFSS
     RANRTVLENI LELLDEMFFN PSSCVCASLR LSLLNEFFLP FLHSLKNDLL LTWACRKIQT
     LVSCLTESLT LEIKTDCEQQ LITKIGCYKI CGIIYNELDL ECLKNEVNGS YLGSDSQMKN
     ELIKKLVSCA VGAKKECCRD SKLGSIQRHF FEYRCAAQNC IIALVKKTQS HLKHYEGFIF
     NDCWESIIDN EVKYEFDREI QEEEQSAGKM YYSREEKPSS AESENQVELS VLLDSSLSVM
     ATQFDFTESL EVSIHCAETE TESANDKDVL KFYSKTKLDF LDQHPCMQAM VNVINYMDHM
     GMIPNDADTP LPAWMASMRD FLNFGSINVR LFIARIIVQC FHVFRPFYLE WISPIIKLIV
     MDEFGSNILH YFRVDLIVVL FEWTAHLKED EAIPKDSLND LLKFCVQHCW SKSGKVFKRN
     LRIIETMLVL WKPFVTLDPS YCLLILEKIC FPLDDENENV CGISILCLCL NTVPETFSFL
     TDPNYESGIF SHLVGLLSLK KVKVYKLAAF VCGLSLKVLN ELQTDCEWLL KNMKAVMSRM
     TGTILGRTKC LFCLREILPN YPEFALQFCN DLLDWFPSLQ GDLKTACLEG FLAVSKYKGD
     LFEELKSRGF LKVFSLRYER DQVLGMYIVK NLHANLTVEN ISDLVSSFSS VVGDFSSSCR
     RAFAEMCCSL YTKLSSLNDS SENSKAALAT TKMHLLTMLS DSNKSIRQLV YNFWCDASRL
     EISTSARLLN CLSQLYTCAT ESTFLSHASY VMLELTCHSP DYTRLIYDHP LEDCTFENLP
     ISTHWQSRYA SLEVPAYMQT DTHSVEQENQ QLLGLASLLP QSLVLFIANA KNVGNISADT
     FELDLDESDS SDNLTVILDK ILQDIKKPKS SRVKKVDDLD GDLQFLKNRI LKDTEEKAFF
     VNLDRKRQKV IERLKQQSLD LRGKYRRGDF PDIQIPYSAV IITLQAVAEL DRVFAGQLFE
     SLMCGVAANV IEIYNYEMTE KYFDSISDGV RDIFRSMVTF HRPLVSCLMN FLYNFIEYVH
     FEPTDIANVA IGSGQPDCGI VLLERRIEVA FVDISAVTCQ EKRLRQVNET DRLWVELARL
     YKQCGELENL RAVFTKHLLT TEKTKLALEM EAAGDFEGAA AIYGETFSNK QRKSGDIVEK
     AEANLLYEAR IRCLEMLNDW KGLETWSTTF GSIGQTTKLD QIWETDYLIN MHLPVFLRSK
     LKIALTSDSA ALEELSAFVE QNQTVPKNRE ILENRHSGLL VLLNILREDF TKSQYFLNLA
     IDSFLKCYPT LRVCDVTARL KLVQDLLPVS ETAKFLHLLH ASEHFKLENV VRLCRFWLRY
     GLDVETTLTT TADDVVLNRK TFLEIFGKRL VDSGISVSNV RQSLIPFRLQ FGYQYLKCAV
     RQNNHGVLLQ RLQDKHLLLE ASNYETWALL QLANCANAVK SRTDYLMQAL NLFDLKRISD
     PEVNVTEGSS ADQFALIGML FDNVAETVVA SSENTLAEFC LSRLISKTDT ADISELVTLC
     YGQAFRYLKL SCQYSSQLNI ESPKLTEPLM ELSSFCDRIL RKNGHTSLVN SECACVMVRS
     ILKSMKNGSH LARQLFPRLL SVMEKYPESE LEFQAEIDSV PSWMFLSWMN QMLSALKRSN
     KFYSILERIA DDYPQALIYP LLMLKSATGD VGETDFYRLQ LKLRKTKIVK DFIDALTLLS
     HPDIVFKAIS LLLQHAIDEL ESIIFNISNK SNEARKEAIA KLFSFVTFTD IRRDFLGSFW
     KCYFKKYLPK MQEIFSVDLC ALDNKAAENY LRLCSSFLSE LRTFYIPECC PNNLNEYSPW
     LTGYRPHPMD VFLEIPGQYS GDRRPFPERH VHIIGFASDV STILSSLYK
//