ID A0A0V1I9C1_9BILA Unreviewed; 1224 AA.
AC A0A0V1I9C1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KRZ19058.1};
GN Name=RAPGEF4 {ECO:0000313|EMBL:KRZ19058.1};
GN ORFNames=T11_9092 {ECO:0000313|EMBL:KRZ19058.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ19058.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ19058.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ19058.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ19058.1}.
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DR EMBL; JYDP01000001; KRZ19058.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1I9C1; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 59..149
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 422..504
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 574..675
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 709..857
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 990..1219
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 226..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..321
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 138186 MW; ED7B43150F12E9FE CRC64;
MSSPKSNPCD AQAMSPKTKN IFKTALLTMA LKRLCSKSIK KVSHAEYNLV ADRIRGVAAF
EHFSQQLVEL LASHGLYEEL DAGIVLFCEG KPSSNWYALL DGSVDLYCYD PEKSSELVKI
KTLHSGCTFG EGALNKQRQP CTAIVSQRSQ FIRLDFSSLS LIWEQYENEL MQNTVSLESI
VKNKFVKASS SKMSKGVKQA DSVSSSAFKS ETSAFAAAAN YKPSKEEAVN CDPKQTTTNV
GEQMPLKANQ PFPTSRGVAA SDSSALLSGR AKYSPLMDTT SSASSFLSDT DQSTTDSQLS
SKFSIKIKKK KKKKKKPEKR KGPKNNFQPF HSIYCTAPAD SSVDPEHEVN NTLRKSSSMG
DKLEAKNPTS NIGDPVTEPA NGITTNATAT TRPDDSQINN NLIELKNLLT PDMQISWASR
VFRSAMVVRS PNMIRDRKFQ MTLYKRCMVG TEMVDWLLRQ SNSIVQNRMQ AAGIWQVLLE
EGIIHHVTHE YPFLDKYLFY RWVEDERSTD AAVRALNLSD DDGIYSENDF LLAISNLSIM
GPDALFRMVL RKAPNERSNE ELEVVFEELL NIKALSNLST MVKRELATVI MFEQHQNAGT
VLFRQGDQGK SWYIILKGSV NVVIHGKGVV CTLQEGDDFG KLALVNDAPR AATIILNENC
CQFLRVDKHD FDRILRDVEA NTVRLKEHGH DVLVLEKVPI RVNRPPIAYR YSVMAGTPEK
MIEYLLETRI DCAKDEDIAD TFMEDFILTH LIFMPTNELC NALTVYYQQG CSSINGNSAL
SESIMTESVE HQLSFRKRVI AFLQAWVQIS GHMFFEDPVG AAFIEVVVVE MYCAILEDSR
DHPQLLPELT VVEKLMRERE QALGSSARPP VILSDNNFIR ELPANSPVNS FDSLRTSTLK
IRVDQTCETI KRMASQKLGL GNGEGVELVE VKSSREKNIF TPNDTGIPTS MSHNGRLFAC
FKDQVESLSP LPEQSGPSES VHSVILETLT STELAQHLLI YHWQLFINTH EYELLYHVVG
RNLFPGKVPV NLDLLIRRFN ELQFWVITEI LLCGSVSKRA HVVKKFIKIA LHCKTNQDLF
SFFAITLGLS NVAISRLSQT WEKVNAKFRK LFFEFESLLD PSRNHRAYRL LVAKMKPPTI
PFIPLLLKDL LFAHEGNKTY FDGMHMMAQT LRNHRMYKSQ MPQIDSSKIP MDAQHLVRNF
RIIDDQRKFL RLSQLLEPKQ KDTT
//
