ID A0A0V1JRI4_TRIPS Unreviewed; 1133 AA.
AC A0A0V1JRI4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|EMBL:KRZ37564.1};
GN Name=SLC12A6 {ECO:0000313|EMBL:KRZ37564.1};
GN ORFNames=T4A_2354 {ECO:0000313|EMBL:KRY73792.1}, T4C_7137
GN {ECO:0000313|EMBL:KRZ37564.1}, T4E_10519
GN {ECO:0000313|EMBL:KRX89312.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRZ37564.1, ECO:0000313|Proteomes:UP000054826};
RN [1] {ECO:0000313|Proteomes:UP000054632, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS13 {ECO:0000313|EMBL:KRY73792.1}, ISS141
RC {ECO:0000313|EMBL:KRX89312.1}, and ISS176
RC {ECO:0000313|EMBL:KRZ37564.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ37564.1}.
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DR EMBL; JYDU01000202; KRX89312.1; -; Genomic_DNA.
DR EMBL; JYDR01000031; KRY73792.1; -; Genomic_DNA.
DR EMBL; JYDV01000057; KRZ37564.1; -; Genomic_DNA.
DR EMBL; JYDV01000057; KRZ37565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1JRI4; -.
DR STRING; 6337.A0A0V1JRI4; -.
DR Proteomes; UP000054632; Unassembled WGS sequence.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR Proteomes; UP000054826; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF53; K+_CL-COTRANSPORTER; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 128..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..317
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 419..700
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 715..830
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 848..936
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1060..1133
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1133 AA; 127210 MW; C0D08697F8775100 CRC64;
MLASLAVIKH SCECDYPKDE LLKTSPIQLE IMDKIETNEE ITTIKMNTVE ESPSKKTSDA
SMRISQKALA LYEEDGPANI NSVSMYLKSL SGVATDETGP KRAKLGTIFG VYLPSIQHIL
GVQMFLRLIW MVGVGGLIES FSMVFLCCLC TFLTSISISA IATNGKIEID MEDGDKPIFG
QSVFYISSDK IACHSMPSEG LGGGTYFMLS RNLGPEFGGA IGILYYLANT VETAMFLVGG
AEILLIYMAP DLPKFGSNDV TDPQMFNNFR LYGTAFLILI FIICCFGIKF VQFFAPFSLA
CVILSVLGVY IGAFVSHDAE SAKLCLLGDS LLNPLYIMDE NHTLICNRTQ QMNDLYCINS
TETSVKNCDE YYANEEIHSE TGIHPFSGSM LWNNLYSYYM YEGESYPGRK GNSPFEVTQD
IRSSFFVLLA IFFPSTTGIM TGANMSGDLR DPDKSIPIGT IAAQLTTSFI YLSFVILYGG
TMTRSMLTDK YGVSLEGKMV AAKLAWPNDW IVLVGSFTSC IGASLQCLCS SPRLLQSIAK
DNLLPFLNPF SAMTKYNEPF RALIVTALIA EASLMIGGID YVAPVVQVFF LISYCFVNLA
CALQTLLNVP NWRPRFRFYH WSLSVLGALL CLFIMFSTEW YYSILVLLFF AFLYKYIEYK
GAKKEWGDGI RGLALSTAQY SLLRIEDSET HPKNWRPQFL ILLKVDQEHS DTNYKLLHFA
SQLKAGRGLT MVATVIKGSL GNAEDRKNAE RIKNLLKEDM KAAKVKGFTE VVLSEFVNEN
VSTLLQCVGM ASLRPNTVFV AWPVSWRTNY EEHSQEFYSF LDAVCRSTAA DKCFLMVKGL
SMFPDVGDQL SGNIDIWWII HTGGLLVLLP FLLKQDRVWR NCKLRVFTVA QSNDNSVEMK
RDLQRWMYNL RIDATVDVVE LDESKVNEQA YEKTQQMREH QKRPGLKDFS CWNIDTKNND
VANNLPKPEK LENAPRPIKQ SISEQHLSAD VEDVKAHHPL ASFIRKLSVK GQRAEQLQMA
QAAGMPLSHI GYDNPNFEFC DKLPDDTKTQ TDFECLTFSS RQMVRKMNTA LLLNNVIRER
SSTSRLVVLS LPKPPQSKSE FKNYMEYMEA LTDGLPRVLL VRGSGKEVVT IYS
//
