ID A0A0V1K0S7_TRIPS Unreviewed; 221 AA.
AC A0A0V1K0S7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 16.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 5 {ECO:0000256|PIRNR:PIRNR017888};
GN Name=cpsf5 {ECO:0000313|EMBL:KRZ40855.1};
GN ORFNames=T4A_862 {ECO:0000313|EMBL:KRY75246.1}, T4B_5814
GN {ECO:0000313|EMBL:KRZ32545.1}, T4C_5833 {ECO:0000313|EMBL:KRZ40855.1},
GN T4D_6464 {ECO:0000313|EMBL:KRY88618.1}, T4E_5337
GN {ECO:0000313|EMBL:KRY01019.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRZ40855.1, ECO:0000313|Proteomes:UP000054826};
RN [1] {ECO:0000313|Proteomes:UP000054632, ECO:0000313|Proteomes:UP000054805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS13 {ECO:0000313|EMBL:KRY75246.1}, ISS141
RC {ECO:0000313|EMBL:KRY01019.1}, ISS176 {ECO:0000313|EMBL:KRZ40855.1},
RC ISS470 {ECO:0000313|EMBL:KRY88618.1}, and ISS588
RC {ECO:0000313|EMBL:KRZ32545.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the cleavage factor Im (CFIm) complex that
CC functions as an activator of the pre-mRNA 3'-end cleavage and
CC polyadenylation processing required for the maturation of pre-mRNA into
CC functional mRNAs. CFIm contributes to the recruitment of multiprotein
CC complexes on specific sequences on the pre-mRNA 3'-end, so called
CC cleavage and polyadenylation signals (pA signals). Most pre-mRNAs
CC contain multiple pA signals, resulting in alternative cleavage and
CC polyadenylation (APA) producing mRNAs with variable 3'-end formation.
CC The CFIm complex acts as a key regulator of cleavage and
CC polyadenylation site choice during APA through its binding to 5'-UGUA-
CC 3' elements localized in the 3'-untranslated region (UTR) for a huge
CC number of pre-mRNAs. {ECO:0000256|PIRNR:PIRNR017888}.
CC -!- SUBUNIT: Homodimer (via N- and C-terminus); binds RNA as homodimer.
CC Component of the cleavage factor Im (CFIm) complex.
CC {ECO:0000256|PIRNR:PIRNR017888}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR017888}.
CC Cytoplasm {ECO:0000256|PIRNR:PIRNR017888}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
CC {ECO:0000256|ARBA:ARBA00009710, ECO:0000256|PIRNR:PIRNR017888}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ40855.1}.
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DR EMBL; JYDU01000005; KRY01019.1; -; Genomic_DNA.
DR EMBL; JYDR01000019; KRY75246.1; -; Genomic_DNA.
DR EMBL; JYDT01000040; KRY88618.1; -; Genomic_DNA.
DR EMBL; JYDS01000015; KRZ32545.1; -; Genomic_DNA.
DR EMBL; JYDV01000024; KRZ40855.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1K0S7; -.
DR STRING; 6337.A0A0V1K0S7; -.
DR Proteomes; UP000054632; Unassembled WGS sequence.
DR Proteomes; UP000054805; Unassembled WGS sequence.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR Proteomes; UP000054826; Unassembled WGS sequence.
DR Proteomes; UP000054995; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR016706; Cleav_polyA_spec_factor_su5.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR PANTHER; PTHR13047:SF0; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 5; 1.
DR PANTHER; PTHR13047; PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT; 1.
DR Pfam; PF13869; NUDIX_2; 1.
DR PIRSF; PIRSF017888; CPSF-25; 1.
DR SUPFAM; SSF55811; Nudix; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017888};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR017888};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017888};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR017888}.
SQ SEQUENCE 221 AA; 25333 MW; 85DB31F9069426CA CRC64;
MVVHGCSLVP FGTDVDQTYL TSTSDTLNRT VNVYPLTNYT FGSKSAQQER DQTVQARFTR
MRNEYEKHGM RRSVDGVLIV HEHNLPHVLL LQLGSTFFRL PGGELEPGED EVEGLKRLLT
DCLGREDGEQ TPWVIEDTLS NWWRPNFEPA RYPYLCTHVC KPKEHIKMLL VQLPEKALFA
VPRNYKLVAA PIFELYDNSA GYGPLISSLP QALSRFNFLY R
//
