ID A0A0V1KL94_9BILA Unreviewed; 810 AA.
AC A0A0V1KL94;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Phosphatidylinositol 4-kinase type 2 {ECO:0000256|RuleBase:RU367084};
DE EC=2.7.1.67 {ECO:0000256|RuleBase:RU367084};
GN Name=pi4k2b {ECO:0000313|EMBL:KRZ48004.1};
GN ORFNames=T02_10714 {ECO:0000313|EMBL:KRZ48004.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ48004.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ48004.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ48004.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|RuleBase:RU367084};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367084};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU367084}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941,
CC ECO:0000256|RuleBase:RU367084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ48004.1}.
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DR EMBL; JYDW01000493; KRZ48004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1KL94; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR039756; Lsb6/PI4K2.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR12865:SF1; PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2; 1.
DR PANTHER; PTHR12865; PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU367084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|RuleBase:RU367084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367084};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367084};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transferase {ECO:0000256|RuleBase:RU367084}.
FT DOMAIN 474..784
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 810 AA; 94533 MW; 01205600354545F4 CRC64;
MATVHFSLLG QKEMQGLVEL DNLKFVKLIV HADGDVCFNE AVCFDDFNDF VFILKKMEKA
LSKLRDLLNS ELNDKRNVSR TIVNVVNTTV RCKKGVSESF MSVFSRISCY EDAMSLHNEM
CYSATLHIFS QCWVNFIRNK LPPSLHCECL LWIDMHILAV VDCPLYFTDF VISSFAMGFP
LNAAALGSLK HLILICNISY PKLYTAMYNL LQPEIFKLSF RLHFYSVLDT FMHSTHLPTY
LVAAFIKKLS RLSLRAPLDS CIILLGLIRN WLIRHPACQF LVNRQDEQLQ IKNDPYNMDE
LNPQLSNAME SFLWEIKTLK NHYNEEVANM ANFVDQLLPS KEVPLKMESA VERVFNKSLL
RFDGDLAAVC DPPEELFILL FFRNMDQENE FIKKGEMPNF AQNSADVDEA ELFTSGDTVH
ILYNSEDEEV SESTWKTLHG QIDSLPFLEQ QSWQKNDFEF SCMKQSIEQA VSNGFFPVRL
PGRSFGSYLV LDEEKNHVGI FKPKDEEEYA TRNPSWMGYF QKMFRLRCPR RGCILANQAY
LSEVGASIVD EYLDLKIVPK TKVAYLASPT FNYSSAEKRK AEQQRERISG VNLPDKVGSL
QCVVEGFQPC TFWLKEFASK KLLDNKLQYE LQLLFERVII LDYIIRNTNR TAENLLISYN
DTRRGNENYA INMAAVDNRY AFPYRHPRRR RPYTYYWATL PLAKKPFSNE TRSFILRKLN
DMNYMSSLFL QLKRLFELDE NFDKNYFMLQ IMLMHGQIFN LKMALENRET PYELVKRHPV
YIVPHPDDFT LPAGFLTDKL LQWLKRKYRK
//