ID A0A0V1KT41_9BILA Unreviewed; 2437 AA.
AC A0A0V1KT41;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=General transcription factor IIH subunit 4 {ECO:0000256|RuleBase:RU364024};
GN Name=pxf-1 {ECO:0000313|EMBL:KRZ50474.1};
GN ORFNames=T02_14044 {ECO:0000313|EMBL:KRZ50474.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ50474.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ50474.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ50474.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA.
CC {ECO:0000256|RuleBase:RU364024}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364024}.
CC -!- SIMILARITY: Belongs to the TFB2 family. {ECO:0000256|ARBA:ARBA00007132,
CC ECO:0000256|RuleBase:RU364024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ50474.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDW01000263; KRZ50474.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.2610; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR040662; Tfb2_C.
DR InterPro; IPR004598; TFIIH_p52/Tfb2.
DR NCBIfam; TIGR00625; tfb2; 1.
DR PANTHER; PTHR13152:SF0; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4; 1.
DR PANTHER; PTHR13152; TFIIH, POLYPEPTIDE 4; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF03849; Tfb2; 1.
DR Pfam; PF18307; Tfb2_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU364024};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU364024};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364024};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364024};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364024}.
FT DOMAIN 572..618
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 904..969
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1034..1153
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1154..1225
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1488..1600
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1625..1854
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 763..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2121..2164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..859
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2437 AA; 269823 MW; 46572181B7670F7F CRC64;
MAHMRRIVQQ YKRTATNFIV LTTVRNDYKG RIGPIMQKYI PKGKMNSTHK VPQTFLNYLS
QLPSGILNKL YESAVACTGI YRYLPSVAQQ IVMRLSLVSS GTTIADIEGW MVDEKKDILH
ESLKYLRQLH ILQECNLSSI ESVVLNRVFA KNLRLALLCK DTICFKTVTV DPKHQKSFAD
LDSYASERWE SVLKYLALPS AQSEKSVSVE TKRVLQDSGL IQLCDSKMQL TSDGFQFILY
DRRQQLWTYL LHYLAQLEKK GSPVHDCIML ILQACLGSHR AAYSTENLTE AALNFIQHLR
EIGLVHQRKR SAGWFYYTPL ISVLTGLKSS SSSSKEGFLI VETNFRVYCY TDSVLDLAIV
STFCEPLYRF PNLVACILNR ESVRRAFQVN ISAEQIIQYL FSNAHKNMQK QTPTIPSTVT
DQIKLWEMER DRFKFDPGVM YSNFFSDTDY ITIRDYAKDL GVLLCEHEAN RALVVSADGH
EQRIRKLSDN CSDRSNSATL EFCPTLILFY FFLVWGSLNF LSQSIACWLI DASDFLLRMA
DTAVIEALRK PSKFRNLKEV QLVYFFLRRL DVFRGVDDQT LRTICQSARY EQFQQAGKFL
YKKGQRSFCW YILLSGAVFC DGRIYLPVES FGKRVRFSEH CRISDCILLE SSEMIVIDYN
STEPSVGSYP ESREQLPMAA TSLVVNRVPV ADGEPTTSST SSCSTSPSMC SSKVVLCRPI
HQTTASTSFA ASFKKACTVG EQQSSSCSVD EVEISTVAEI PPNLLPNRRL SSSQQQQKHR
HDGTLAMIRR SNSIRSSGSS SAGGRVSGFK PIAAIPSTSS TTMSDDDFSG LPEISVDSDD
EDDDEAELEE EDEEEEEEGC CLYAESSFTG HLRDLVRECL EKLPTERTDD DIAILLDFVQ
HMSSFASLPI YVKCELCRKM VFAVVDKAGT IVMKHGEQLD SWSVVINGEV EVVFPDGHRY
EYHIGDCFGV QPTEQVQFHQ GEMRTLVDDC QFVLVAQADY VQIISKLSDS YTRQLDSAGQ
VVCEKEKRAF ESRVGYVLTK AKPCKLISAL FEDRRDCVVD PHFVEDFLLT YRTFVDNPAE
VLEKILACFS EPSKREKVAR LVLLWVNNHF GDFESNAEMT NLLEKFDKML EDEAMFNHQQ
LLNIACSVKS RTRNVTYTRS NRDEVLHFSI LGGTEKNNGI YVVKVAAGSA AERVGLKRGD
QIIEVNGHNF RNIARHRALE VLRGSTHLSM VVKSNLLGFK EMLVADQCDA GALLAPVLLQ
QAVATSKDGS SRRRMSPVQP RRSLVQLHQL GGVDGLPMPS LRPPPRQQKH SLHLETQRAV
MPALVHALAN TNTTTTTTSS RTLARLNHAG KESGGSGSRL GKLIKKLRQG SSSSALSLDA
DDDDVDNDHV DGHEPRVDDG GRKCSKQKIR QTLDDCDATD EAVRRATLGR PTGAQSVSMP
SGVPLLGRRL KHSRSNPDLS STANQPILPG GFGQMISQYY EPVRPQHPEH ILKVYRIDQT
FKYLSVYKET SAQNVVQLAL QEFGMCNNNS GVGNDAVHNG SSSSSTTTTT TTANGDEWSL
CEVTVTTDGL IKQRRLPAQM QNLAERISLN SRYYLKNNNC PLPLVPDELA PDLLKDAQAQ
LGCLHASIVA AQLTLQDFAA FASIEPAEYV ANLFKLGGAP TRWPRLADFE QSVNRETFWV
ATEVCKERNS IRRAKIVKKF IKIANHCRDF KNFNSMFAII SGLEKPCVRR LHNTWDKISS
KYTKMLDNLQ SLLDPSRNMS KYRQHLADAS NDPPVIPLLP VLKKDLTFLH ECNPTWCDGG
MVNFEKLRMV AKEIRFVTKL ASAPYELSSM FERSGNQAQL NDALLHMNTF EGGSSVATMK
KQHVQHRVPL SRKKLYEQAL MVRRVKFYLT QFEPISDESV LDKLSLELEP VTVTSGGGGG
GGAHSASTGN LGVVTVASAG KRSQPSPSLS SGSSMSVTSS DCSRRCNGPK FGVESPHAVQ
KMLSLVDHSR VRASSNNTRA IGIGSPPTSP GAPLKAVRPA TAAVAHSLLY FGSNIHQHQQ
QQHGRFNNHD LNTFAIPPPL SSVVPVDLTC ESSAVTSSIT PSRLHGSASA TSSTDSVISS
HQSDLLPLSS SSSSYIPHAV SCDSTDSGHG SLDSPSMITG VGVASSSSSS SPPSQRQSYP
PRPNTIALKA ASNSTTHYDL YSTTTTGVVV STKPFRSFEK AQQQQQQQQP QQNFRFTAPQ
HENRASSSVA SSTFLKQSQP LSSSLTIGSR RLATTADQSQ SDTNNGATQV SRHLASVPVA
AAVLKSPSKC STWKSFFLEN KTHKKLSHTE KSELVKHQTF FVSTVVINQR EPSFSLVIGT
TSAPEVTSIF PESGTIENGP WQYFSSVAFV HAVNDDCIAG ATGVTGLVLK TVDIVVVCFA
EGLPSTRSVN GVSGQSGMET VDESYQIFKV SASLTAA
//
