ID A0A0V1KUH2_9BILA Unreviewed; 3282 AA.
AC A0A0V1KUH2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=T02_5775 {ECO:0000313|EMBL:KRZ50775.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ50775.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ50775.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ50775.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ50775.1}.
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DR EMBL; JYDW01000250; KRZ50775.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1KUH2; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR031559; SMG1.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRZ50775.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1895..2221
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3250..3282
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1342..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1675..1702
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2909..2939
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1353..1368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3282 AA; 375435 MW; 72CBA7A61AFF8C59 CRC64;
MVDYQRSIFY TVSMLRNLLF IMYSDSSSLW LSNADSMTEA VDLSTLWSKI RTILYATDGD
VKELVQACEQ FKTLFESQAN SDGHVQTSIS IIDVAVGFEK FFTVSRFNEE FLRCIQSLLL
PLTMNAAGGE IVKLFKYLVD RIYDLRFECK QAMLLKIVSE LMTTSRVILC FADSLYLLAS
LFKMQCMGFY YPNTLELFLE IFLRCFGLLI PIVGMPDDFF QILLRLLVVL QPRADKKKQS
DRLIRVGRKV LHLYFPEDFQ RGTNILLALI KVAQDDAERF KNGLNFNERC KYSRRIWRSV
SLFNSMISIF STEERQWNQH REFLQFLDTM VPMLTRIAVL MLRTSEGRRS AIVDLATRSI
AQLHELLPAG DNSIFVKSIV ELVFLFLDPN LTLLYLDIEN ILELIKQIIV HKDRCLFVVH
ICALIGPNGI LPKLRFHQEA TIVRLTMEIY RSLLLLKGDL CSIMSYRQHK ITSVSIFNRM
IVGELVVSLE MLACRGEVEG LDQQPLKIEF DNIWNGQLES DVQLSELKFI LHFNASLLML
VCRSEAFRWI SIANVPDIYS VLTGNSLLSS KWLTVFFPSV HYALLMLLRI YCTSYRHFSS
DEILCMLRKQ GTYNFHDYVE MIKQLLMNDG ISVAVRKLLY EWINCIFSVV IKDDDFKSAY
SADLVELAWA AVTFHCDIIK CKDEFLCMLV QIFYSQFSYP KIVREKLYAT ILLASCYSCD
ECVSRGLQDI LPEFSYDDPD ERAIMLKMAN NAQLSSNDQQ PASSHLFATL MDFVLLNIDA
SELTVFHLKY FTDTAKFMIQ YCSTRTEVEV LINEYPGSVW MMALTMLANC CIENRLKTIY
GPKSSSILHL VEIALGSVTR VASSSDRTQL ADQLSAERLH SVQCNFLLYF VEILYKMMYR
CYTNIDPQAH VGLGSFYRIN WNSFDAYFRK IRPLIVGLAS RQGEYETVLM WISRLSSSDP
ILDETPPWGI YSFLLNVVDA YVMLQAAPSV IGFSHWIENK LKIDDQLIKI CSHKASEQYE
ITASMLTDWV MSVESGNNSN PDVVDVLSIQ IKYCYEEIVD CFVKLGDWSM AATWLKRGKQ
SCGVPVYKWQ PLVDYIERMA NLAANLEKRE AKIDGGDGDA DQQQLVKKRP TDYRNFLCYV
DCTFLNIMEN NEFGSDGMEE KLHILLQDLE TRRFLYSTYM KPLSLCKDYE IRLDIIKVLE
NACRWKNWIL GPVDTSQLRI DQLTVMYSIF CMTNVLPCGR EVCLSDFCTS FAKRARKTGN
LNLCLRIWRR HFGCNSTAEL CSFLLVLIAR YSQALDCAVE VAKLLWEQGR GAGCDQRVDS
ALKFLTQAVA VAVWANIPST DGSTKSTPTT ADVDDDRDDD DDYDDDDDNI PLAKGLVVLA
SWLGDVQFGK RHLPPPNNDD AEIAFQALFQ SRLQQLQTEF DLNDNIADGV ALSLAVQFCR
TSVKAHHHYV GWLNSIIFSL VEEKEGFHAF RLSSKEKQFI TSLLSAKSKV NLDNVLLLLE
TVRSEQNQLT WNVICPDVRK VCTSSFALEK LHEWWEARHG HLFNLYNTLC ESYFVILRNN
YPDDFITVDA TIQIIRLVTS HYTDLKDCLH DGFSSVDVGC WKRRAVIPQL FAHLGHRNAG
VRTLFADVLC SMAVEFPAMV IYPALAGLSG DGKHYRPADF YAEEMDSKLN SSAEVSFNES
EAEEEEEEEN DYRNELIESQ FRQNCCKRIL DCLSELYPQM VRDTTEFVAE LKRIILLHDE
VWYSLLTSMR PEVARRLRDF YQNQEQQLPI SDERKEQLKR GKTLLMKKML FQILVDLHEV
TSKLPQTKSE KIFSETFSPR IGKIVEQVED ENCIDLNKIW DQFCQLHADL AEQTKNKSWL
LKMEEISPKL AEMKDTMIPI PGVFENDQPV MIKSVCAEVK ILPTKTKPKK FSFVGSNGVK
YRYLLKGAED LHLDERVSQF LNFSNILFQS SKKSLGEAVY HARSYAVTPL GQRAGLIQWV
DNFVPLFLLY RKWQLRQGGK NVTRPSELFY EKLHTLLSNE GLPVKHMRNR SKCPLPILRK
VLDRLIEETP RTILSDAFWI KHVTSESWWK AQVNFARSMA VVAIIGYVIG LGDRHLDNLL
VNLETGEVVN IDYNVCFEKG KLLRVPETVP FRLTQNIVNA LGISGVEGEF RISCENVLRL
FREHKNTFVT LLETFVHDPL IDWRKTYGIG PNGLVVHSIL STIQGDMKLR KYVEQSRDWN
KRFFLYRYEE CKALWIENRN SFNETFKTSS EMLDQMEIIC NSIANTRQRC ATYEAVLKLI
SQATENPDHS LYKFLENNQD FTGVYEEVIA SYAELMSKLK KNQELNVTYS NSISQLNNLH
GFRQKVDDAF SKPPQSFIEL AVEFLRATGQ TQKIQPYKNL ESKIVPSFSA LRDLCNSLLD
LVEAYRSAQL LVPAVDRKKH RLHVWLELLE SVSKCSCDSG GGGGLEANVQ QTERLLEQIG
QQQQRGGRTS PEQFYANACR TVRMFQSVLD NGEKMPTIRA GDLKKIFANT ADMGPVFIAS
SETALVNWLA SIANEMSRLE EGNCCTKADD QGNSAEQQAR GMVSFGWMDI YLTVLKYLQS
VRQLLVLPAF EKFSNQSILQ RLDAGQRLFQ CCVSLVEQIS TFLVPTMYRV TVDNHAELSS
WLMGVVDACA TASTLSMDKA WQTLADEQLP VGMEWLEADN FDSHHLLDQL QRINDELRVR
KPIFSHRVGD EAMTVFRHCL DSFMAIKDHL KLLLDCLPPR GGSLPLPTVD YRWSIVLDFI
YNYTMYRCAS VAVSYAEGDQ SASVSAVFVD LPDAVGTMLW KKLLLNSLPS ALLNNVVDSV
NNFRLSTPND VPVSDAHPMV RQYQTDIRNF VQTVQIELTK DACEVLKNAL VPLNGLVRSY
AWHHEIVLKR AVDPLSSPSV VEPTCSTVLI GLNEHLDQLR NIVNELKESR EELSIAAKDT
ISRLTWAAGA NATWSSKLEE FERAKESDLG QFNIAVELCD RFILIADSLY NYESLKLDSE
QLVKLDNAMV ENVKLYLKQL KRYMSIAAGM DPAEIELAKL KPSQEEHVTE KWLLSILADF
EKRNSEANQA LTKVQDEFFA KKTNFRAITE SVRLLLNEHR KFTAEARAYM KHLAFSGDEI
EAKLANFFLH LQKLHTLAFS DVLRTDITSL PDTWDFEATK VAFKRAAYLT NTIFDVLIDF
VDPEAASSHS KARVCRLNYL ILKFTVGNQS KSPNLILDVK SRSGKLNALA LNAWKCVRAK
LEGRNSNSEI PLSIADQVDA LISDATNLDN LALMYEGWTA WV
//