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Database: UniProt
Entry: A0A0V1KWB5_9BILA
LinkDB: A0A0V1KWB5_9BILA
Original site: A0A0V1KWB5_9BILA 
ID   A0A0V1KWB5_9BILA        Unreviewed;      2494 AA.
AC   A0A0V1KWB5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LIG4 {ECO:0000313|EMBL:KRZ51253.1};
GN   ORFNames=T02_11765 {ECO:0000313|EMBL:KRZ51253.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ51253.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ51253.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ51253.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP +
CC         diphosphate.; EC=6.5.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000617};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ51253.1}.
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DR   EMBL; JYDW01000233; KRZ51253.1; -; Genomic_DNA.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:InterPro.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   Gene3D; 4.10.1170.10; -; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027442; MAPKAPK_C.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR004353; Mon1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   Pfam; PF03164; Mon1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR01546; YEAST73DUF.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054721};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:KRZ51253.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT   DOMAIN     1162   1411       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   DOMAIN     1822   1958       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN     2142   2224       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN     2283   2388       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      276    296       {ECO:0000256|SAM:Coils}.
FT   COILED      953    973       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2494 AA;  284683 MW;  E0678C0A828AB27C CRC64;
     MLPFHDACYL GLLSMAEDFR TRSPPEIVNA LRCLLSIFEF SPPIVIEARL HFQVGHMYWS
     FTENIDHARQ HLERAITLAR SHRAFEDVLS DAAYSLAQLY FKTNENALGR NLLYQTIETL
     KNCQGMFCRQ IRLVFQLAQH LVNDRDYITA REVLQLGYQA AVNENCIYIR IMILLSISQL
     YMFESRVKEL HQTLSKVSQL IDSWQGSSIR KAKSSKACLI ELQQLVQMIT HTGHQEQKDE
     QQQYEYFQWI SDEHLCILVY AMTVMEALHC GKFNKARQYA ERALAHVEKL RRLNQEDNMA
     QGLWLLLLEH SILSQLNTGH YVSAVKEISL LKSACHCNPR LFYQYGSRLH MLLGLYAVSM
     DQAQAGEAQF AAALRFNRDP KLSFYLNLNL AVLYLQCGRE SEFYNLMDIS PERLAEQSVN
     LRAASLFVRG MHLMLQRRYP EAKKVLCETL ELTSKEDLNH LVSFCFVLIG QMLLGVNPRT
     EHLKEALKLF TSSLHLAQSS ADVTAQVWSS GALKNLYAIC QNADQQKHYG QLEGDLVRGM
     LQEQEHSRQL AEHQLINITD LMDPLALLHH FRVLLLKLLL NLCMAEISQA SSHVDAFNVP
     RCVPDDKKSD DTTESELPPY RSVPKITDEM ETLAITEQIL DTVICDKLSV FCEESLHLHS
     CSRSSEPRSS DALQSYVTTL LSDHDKHVFV LSDAGKPVYT RHCSEEELSS LMGVIQALVS
     FVSSQNEGDE LRTIRAGVWT FVFSHRAPLI LCLVSRRSDS AEQLSRQLDL VHRQILTVLT
     QVQLSRIFEE RKNFDLRRLL AGTERTLERL ILVMETDFSL LLNAVRCYTL PHSTRETIVQ
     AMSSCCSQPK CIVFAVLLVH DQLVAYSGKK KATLSPSDLA LLINLVASNI SFKDAESWSP
     ICLPAYDENT FLSAHISYLT ENSPACLLLL TAEKDSFFTM SEVRNKIIDK FTRTKALAIL
     NELQQERKRF EINELGIPDL IHFIYKHRTK SQFTSMSLSL PYREEYFEKH LFNRYLLIHN
     FMHSEKHKHN IFYVTGDLEN ILGWVTTAFE IYAVFNPLIT KPEAVSRVEQ LMKWIKKEEN
     NLFLINPGHM SSKSTTVMNN VQSAVKVVDG RSDVVSALKK KSSASDTVEN NGADDKQQFS
     FTYDANGVHL KPLTRMITED YRVSKTVLGV GLNGKVVECF KRKTGEKFAL KVLCDTPKAR
     REVELHCLAR NHKNIVTIYD VYLNSFSNTK CLLIVMECME GGELFSRIQR RGEHAFTERE
     AASIMYDICS AVRFLHSLQI AHRDIKPENL LYTKLTDDAV IKLTDFGFAK RTEPSAVKSL
     ETPCYTPYYV APEILGTEKY DKSCDMWSLG VVMYILLCGF PPFYSSHGLP MSPGMKSRIR
     SGQYVFPSPE WDNTDPSARL RIDQVMNHSW ITGCKAVPET PLCTVSVLSE KKVIWNDVQE
     EMSNALASMR VDCDQMQIKN LSDSKNKLLE KRKKRLFGLK LKMEQSCCSI ESEIPFRDLC
     SILRACASTR NQAEKRRILG KFFHCWRERF KRKYENSVAN SNSSVESFFP ILRLLVPKLD
     NARGPIGLKE NMLAKKFIQI MAIDKNSPDA KALLGFHLPA TKWKMSSTTT GKSDVDFAAL
     ISSMLKSRVL ANVDEEISLF DINRCLDHLA SAHANRSRDQ VEKQIDWCCR NLNAEQFKWF
     VRIVLKDVRL WDSSSMDDDG YCCSVELFKA YRPMLATLIF PGNRICQIFS GSKFYVETKF
     DGERVQLHKD ENNNYKYFSR NGIDFTSSYG STPFVGNLTQ FIHGAFENHV RNCILDGEMI
     AWDRTAKRFV GKGEHVDVKG LKFDSPLNPC YMVFDCLLLN DRPLAGLPLS ERLEQLRSAV
     RDIPERMQIV HQQLVDSADQ VIELLNETVG RGEEGIMVKD PASLYKPNAR TSSAGWFKIK
     PDYINGLVDD LDVLIVGGYF GTGRRSNLLS HFMIALMENY DKKIIETVDD CNFSTPRFVA
     LGRVGSGYSL KELYDFNAKL VQLRLKRGQP PPWLKLGVEK PEVYIHPEQS TIVQVKAAQI
     VTSGQFPLGF TLRFPRVQAI RHDKTWRDCM TVEQFLNFKD LSADCTSKRL AEMKNDNNDQ
     IMNLKTISKK PKRKAIVAAD RRCRVEAMKN LDQSKRMRKY KPISNIFQGR ELCILNGNDT
     FTKENLEGKV VELGGTVVQH PVAGRQTVKV KSVVRASTVD VLKLSWLIRC IQTNSFIQWT
     PKDMLLTTAT MKRHFKRNFD QYGDSYTDPV DSETLHDLLA TVPVEKTDVD DSKSQKFLST
     ISYKYGIFLN CTIYLDFYDD LLSPLRRRIA LSALDRYELL LYEFRANIVD TLTDSLTHVI
     VHSDDLSRLD DLLRFKSDFN ANFHIVTESW VTHCIGEFAI VDESLHSVRT SGESHPAIID
     EEEVEEGDDV IDENPSSSSK QRDFHRKRLP PNEALLKHLG HDSGHSNCLG TDGATTTNAI
     HLQFCTVRQR VIQPKQSSSD EISDDNVNAV MTTG
//
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