ID A0A0V1KWI8_9BILA Unreviewed; 674 AA.
AC A0A0V1KWI8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=ATP-dependent NAD(P)H-hydrate dehydratase {ECO:0000256|ARBA:ARBA00013249};
DE EC=4.2.1.93 {ECO:0000256|ARBA:ARBA00013249};
DE AltName: Full=NAD(P)HX dehydratase {ECO:0000256|ARBA:ARBA00029804};
DE Flags: Fragment;
GN Name=CARKD {ECO:0000313|EMBL:KRZ51462.1};
GN ORFNames=T02_5927 {ECO:0000313|EMBL:KRZ51462.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ51462.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ51462.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ51462.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate;
CC Xref=Rhea:RHEA:32231, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:64076,
CC ChEBI:CHEBI:456216; EC=4.2.1.93;
CC Evidence={ECO:0000256|ARBA:ARBA00000836};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ51462.1}.
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DR EMBL; JYDW01000225; KRZ51462.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1KWI8; -.
DR STRING; 6335.A0A0V1KWI8; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0047453; F:ATP-dependent NAD(P)H-hydrate dehydratase activity; IEA:UniProtKB-EC.
DR CDD; cd01171; YXKO-related; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR HAMAP; MF_01965; NADHX_dehydratase; 1.
DR InterPro; IPR017953; Carbohydrate_kinase_pred_CS.
DR InterPro; IPR000631; CARKD.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00196; yjeF_cterm; 1.
DR PANTHER; PTHR12592:SF0; ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE; 1.
DR PANTHER; PTHR12592; ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER; 1.
DR Pfam; PF01256; Carb_kinase; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS01050; YJEF_C_2; 1.
DR PROSITE; PS51383; YJEF_C_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 27..325
FT /note="YjeF C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51383"
FT DOMAIN 425..477
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT NON_TER 674
FT /evidence="ECO:0000313|EMBL:KRZ51462.1"
SQ SEQUENCE 674 AA; 75267 MW; 3BD679E85D85948F CRC64;
LALFRRFNLL KLLIRKANMC TERHCEVLEV VRRCVPKLEE SNRKGQNGRI CVIGGSYQYT
GAPYFAAISA LKTGADLSFV ICAPEAGQAI KAYSPELIVF PVLTQDAFAD VQEEVLSRVD
VIIIGPGIGR RAELVPFILR IVCEMARTGM PIVVDADGLN AVMTNLDAIR GLKNIVMTPN
ATEFDRLFKA EFEGRVIVTE DTLGAVKLLA AKLQNVTIVR KGPTDIISDG IHVLECAEPC
SLRRCGGQGD VLSGVLGTFL HWTKRNSELF VESNSGGAQY TPTLVAAYGA CRLTRESSRC
AFERHRRGMV ASDMVREIPQ CFARLFPDSQ APSTSSRSGS GGDVKAAILA TSGSGLAPAC
VDVRPQLTFS SIVVIGGQRS HPSQTPFRPK RCSFYSLFLH NLKLSTLRPP RIVIQEEEPT
LPVAMDFTEK LPADICRRVF RYVDLKQRTK AERVSKRWRE IVLDAAAHDD RSVWLYVIFR
EGHLSGHDRM TVRVSYDGPI FWDKSIVYVY LCSCHAYERH EKQLISLFKR IANSVHRLCL
VSSPVRSPFL TNDFYTFILD IFKNLQILYL RELNLENVAT TTVERLATSK TLSRVVVHDC
IHYDSLTDYH RLNNRLMLVK GHLRGLEDLL RSKNAYPEDS EDLPISTVQN RPESNISNMI
NGLTIDSSSP VDAA
//
