ID A0A0V1KYW8_9BILA Unreviewed; 528 AA.
AC A0A0V1KYW8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=tRNA pseudouridine synthase A, mitochondrial {ECO:0000313|EMBL:KRZ52495.1};
GN Name=Pus1 {ECO:0000313|EMBL:KRZ52495.1};
GN ORFNames=T02_10360 {ECO:0000313|EMBL:KRZ52495.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ52495.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ52495.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ52495.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ52495.1}.
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DR EMBL; JYDW01000191; KRZ52495.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1KYW8; -.
DR STRING; 6335.A0A0V1KYW8; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR013730; Fyv7/TAP26.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR Pfam; PF08524; rRNA_processing; 1.
DR PRINTS; PR01854; BR22PROTEIN.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 333..435
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 33..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 239
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 298
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ52495.1"
SQ SEQUENCE 528 AA; 63301 MW; 92BFA34ED3C98A3D CRC64;
MDNLEENSLF KKKKRKLHTY EKAWLNYKHI QEEKEKRKQE KEQKRKNIEA ARERSKLLRK
EKMKYIYKKT RKGQPKLGYQ IEWLLKKIEN QNKVYSTNQR KFMHFFEYMR LKYCYSFTPR
LCEKYFCQMS SELKFNCNDA INSGTDFELN NQKRQKLEND EETRKIIKAE PTETVRIKRY
KYAMFLAYRG KNYHGMQVNP NVPTVEKYIM EALQKLNLIT VDQMVQPSSF KFQRAARTDK
GVSATKQICS LLLPTIEGKE NDTVNLLNGL LPDDIRIFGL QRATKSFDSK KWCDSRSYSY
TLPSYCFRHQ SDLERDKFRL DNKDIEEINR ILMQYVGTHN FYNFTSGKLH KDESCKRFII
RCECGKRFLY NNIEYLTVDI KGQSFLIHQI RKMIGFCVSL IRGDLDPCLQ QKVWQNERIK
VPKAPSLGLV LEEVRMPHYE HYNKRFQATH QRLCWDIYQE KCDEFKQAYI IKDILETDES
EKIFEEWLTY LTEKFWNEND VDDVSIVGHS DNVQTDGKSS LKEKVELS
//
