ID A0A0V1L6U7_9BILA Unreviewed; 1040 AA.
AC A0A0V1L6U7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Regulator of nonsense transcripts 1 {ECO:0000313|EMBL:KRZ55274.1};
GN Name=Upf1 {ECO:0000313|EMBL:KRZ55274.1};
GN ORFNames=T02_9666 {ECO:0000313|EMBL:KRZ55274.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ55274.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ55274.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ55274.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01341}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ55274.1}.
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DR EMBL; JYDW01000118; KRZ55274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1L6U7; -.
DR STRING; 6335.A0A0V1L6U7; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 65..223
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 134..164
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 934..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 117556 MW; 11BFDB9C21ABBFF7 CRC64;
MDVREQQRRK KNSPQSLSFY NTGQRMQMLD QTQDSELDYL DYSSDNDTTL KSTNAIAQLS
EEELPVVLPE HACRYCGYHE PSSVVLCNYC KKWFCNGRLT NSAGSHIITH LVRSRHKEVT
LHSMGPLGET VLECYNCGCR NVFLLGFVSA TTESVVVLLC RQPCANQNSL KDLDWDHKQW
KPLICDKAFI SWLVSIPTLK EMKNTRRIAP ADMVKLEELW KENPEGTLED LENPQNEAEP
EAVSLRYDNA EHYKSVFGPL IFMEADYECR LKEAQSQQNI TVRWDVGLNK KRIAYFSLNK
ISDTEVKLMT GDELRLNSNF DGKVWRASGH VIKVPDNFGE EVGIELINAH DAPPPDVTYG
YSVDFVWKST SFDRMFIALR KLTDDGFVSH AIHRKILGHD YEAPPLNILY PKHYSAPGLP
ELNHSQVMAV REVLTRSISL IQGPPGTGKT VTSASIVYHL AKAGGTPILV CAPSNVAVDQ
LAEKINRTGL KVIRMCAKSR EAIDSPVSFL ALHNQVRYLE GEEELDKLWQ LKEETGELSS
LDEYRFRFLR SKCERDLLKH ADVVCCTCVA AGDPRFNHIR FRAVLIDEST QATEPECLIP
IMAGARQVIL VGDHCQLGPV VMCKKAARAG LNQSLFERLV ILGNRPIRLQ VQYRMHPLLS
SLPSNLFYEG TLQNGVTEQE RILEGVDFRW PNPTVPMFFW CTASQEEISS SGTSFLNRAE
AAHIEKIATK FLRSGIRADQ IGIITPYEGQ RAYIVQHMLL SGPLNNKLYQ EIEVASVDAF
QGREKDIILL SCVRSNEHSG IGFLNDPRRL NVALTRARYG LIIVGNPKVL SRQPMWHSLL
RFCRENHCLL DGPLNALKEY KVDFNKGKSN LPVMKTITVK DMLLNSYNQS RNKLPCRPKV
NSSYRDELSL ISMGRSQAAS SLLNSFDPPI PYNMFMLPTS SQRNAKEGGE MRDRRRRKMR
SASGRRLVPS DETSASSSQS MAFQSQSDFT QEVEVDESLR IQLESMMLSQ DTNYEHSEEV
SSSSSMDDGS SSDFYPASQQ
//
