ID A0A0V1L9U6_9BILA Unreviewed; 2650 AA.
AC A0A0V1L9U6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE SubName: Full=Dedicator of cytokinesis protein 6 {ECO:0000313|EMBL:KRZ55774.1};
DE Flags: Fragment;
GN Name=DOCK6 {ECO:0000313|EMBL:KRZ55774.1};
GN ORFNames=T02_12923 {ECO:0000313|EMBL:KRZ55774.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ55774.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ55774.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ55774.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ55774.1}.
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DR EMBL; JYDW01000108; KRZ55774.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11695; DHR2_DOCK_C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF03062; MBOAT; 2.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2215..2235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2247..2263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2269..2285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2292..2311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2389..2408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2506..2525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2546..2570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2582..2602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 599..766
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1646..2109
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 2613..2638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2650
FT /evidence="ECO:0000313|EMBL:KRZ55774.1"
SQ SEQUENCE 2650 AA; 296823 MW; AECD427173252BA6 CRC64;
LVVGFDLNCC AAQCAKIPIM QQRAFARRLT KLHASDVRRQ VASSYPHKAE STSSSNRASL
TNFPNVYDVV DPVDFEEYVS QLKASVYEHG WNVRVSFADF PPNDIELKTI PKNEAFTQRA
LLHANLEKLE NPVKDILAAY SADYVVVLRR YENFSTGELY KKNQSERLAS VKFGPTQIYE
VDLDSIAPDD SVRTSCVSFV SGSEVCSAGT RRSWSSSASD LQVDCDLFIP GIIQRRPLSE
LDALNDTLRQ KQRQSVVFSP SMLPPEEEMI ELRYIPPIPA EPQAHKLIVS VLSLKLEPEF
EPIFGSMWLF DADKKRRVSE NFYFDNNSEE MRALLRRSTP YQDASTCCMS ALFKITCPSP
DLFLVIRLEK VLQPGDINDA VDPYLKEDKN KEKLTANAVE YCDRLGQYRM ALAWSAVDLS
KIIGSASTLE RGCTSATGQN YECHVSDSDS TLSSGTLGEC VSQKTMRKSA SGSVSRSTPV
RTSWRRSVKN NDDPLEMDSF KPLIVTVNNF FKQEEDRLTD DDLAKYLCEI RKPSSAIKRL
KCIGGVMKID VSPCLEDLEN TLSPELNPLE PYNATKPPAY KEILEFPLKQ IFAPNLFYRN
MLFIYPKSVN FSSRSGVARN IAIKVQLIRA ADPPLMAFFG KSSCPEMQNY AFTIVNYHNK
SPQFYDEIKV KLPVDLSDSH HLLFTFYHVS CRQKSTSDNP ESAVPVGYSW LPLVANGQLP
SGDISLPVSL DALPTSYYYL SPEVNLPNIK WLDNHRHSFF IRLRPVTTVF TEDSHIDNFF
TLYRQLKTNS ATMSETDVHN VIRSMTKARP ESLVKFLYII LNKLFNLMLF TSSGYSPFVS
SVCFEMIGQL VKIISKLVDV SCDQHDRSSL LAAYIKYGRL CTTGGKGVVN LLSLMTERVD
GEEEASAKST AGPGRSNYYV DQQQEESGLA HRSPSHNDLV DVIRGFEKSS SCRSTFDSAG
VAHRQGSSLV TAGQVGKQLH EEITMQWLAS VGPSREMACA NSWFFLEILS KSIAEYLAVN
KRLYLPRKMR LPEHYLDELT ALVSLLVGEM LGRVGKDFHQ ARRINCSVGF FFVDLLSLID
RTFVFGLLRL YWKSTATVVT NTPQAAADVV SLRLDLLRIV CSHEHYITLN LPQLEAPGSA
PVAIFRQAAL RCCSQRAPSP SPSVSSRSSA GSTAAAGTTT GGGCWSSSSA GSSSAPAAAA
GAIGSAELTV DFRSRHFLVG LVLSALASTL EWNVDSSQAA AVALLANLLR AHDSDRRLDD
RSTKSRAASL YFPLLGVVMD ARARLHDPAR ANDPDPDVTM RMIATGLVQF AGSGTTAAVP
GCDDHAPSAD VVAADSVDAD NHRVRLLLTL DTTRNLLLCF CWVIKNIEAS AFRQWLNELP
AARIGHFIDA LHVCVSCFEY KGQQRRRQRH QQRQPAKGGA VTLEQSFDDG QLSAEVNLIV
LDAFEWICKT AVSSECLVSA GSGPGVLGAA LRLLLHMLSC NQSVLVLGQL FASQRAFVEK
YPEIVFDEQV DQCSQLCLQL LRHCASAVAE VRAQAAASLY LLLRRAFESA LVNFSRLKMQ
ITVSLSSLVG GAWFSVDRLR GSLGTVLACV DQADQADTAA VQWSAFVDQA KELVENLNAI
LADTAKMEEC QQDFEMLTDL IYRIAKGYRR SPDLRLAWLQ NLTQKQLERG HHAEAAMCYV
HAAALVSEWG RASGDAPHYW PKGAVAFLAL SENVLEESAA WEVDAFAGSD RDWEPRLPGR
QFSEAGLCGL LEQAAQLFYQ ASMYELMHGA FKLILPVLER RRDYRRIGLV YGRLADALSR
IDDRGPNSDK RLFGTYFRVG FYGAKFADLD GLEYVYREPA ITKLSEISSR LESFYADRFG
AGSVEVIKDS NNVDPARLEP HKAYLQITYV EPYFDRWELR RRVTVFERNH NVSRFVYATP
FTLDGRAHGE LGEQYKRKTV LTTSHSLPYM KSRVLVVHKE QSVLTPVEVA IEDINKKTLE
LELATGQQPP DGKILQMVLQ GCIGTTVNRG PLEIANVFLG EQQQVNGAAG AGAGSSTTVT
TANAGEPVSE VLQNRLRLSF KDFSKKCADA LRENKRLIGP NQREYQKELE RNYLHFTEQL
TPILSSVSVT DVFVYEIVLF DLSKRRFLPQ PISCPRLFPN DRQDNLLITN CPRWSLPFCN
TAVGYTTVKL ALVCHLLLPP LPSELTGTCF PDDYYLKKLL FNMSTTGLFS ASQGLSDPAI
CLLASLICVV PLGFLHRAVF NGKPKRIQHL FFIITGLLLF YINYGMHTIH SLISIFVAYI
LCRYFKGTID SVVIAFVFFM SYLVIGYNVM SSGKYDLSWT MPQCVLTLRL IGLIVDLYDG
MQPKEKLSAY QLEARVDDSP DLLEIAAFSY FFGGCFVGPQ FPLNRFRRFN YSFLWKLVYI
LFWFRFVVLR YQSAWLIAES GCILVGLGYN LDEKSGEQLW DGVRNIRLGR FELSASFQSI
IDSFNYNTNK WAFNYFFKRL KFLGNKMLSH LLTLLFLALW HGTYSGYFVC FLAEFVCIIA
ERQLVAMLNQ HQQLKAKLQS STMIYLPLWC VRKFVVLLSC AYGFLPFALL TIDKWWKVYK
SVYFFGWIMY GIVWPLIVVS YWSTHDWRRS KAGNGTIPSK ENAQVNKSNG SDGSNVHQNV
DNAINKAKIN
//
