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Database: UniProt
Entry: A0A0V1LAK0_9BILA
LinkDB: A0A0V1LAK0_9BILA
Original site: A0A0V1LAK0_9BILA 
ID   A0A0V1LAK0_9BILA        Unreviewed;      2696 AA.
AC   A0A0V1LAK0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   07-NOV-2018, entry version 13.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor itr-1 {ECO:0000313|EMBL:KRZ56375.1};
GN   Name=itr-1 {ECO:0000313|EMBL:KRZ56375.1};
GN   ORFNames=T02_12326 {ECO:0000313|EMBL:KRZ56375.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ56375.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ56375.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ56375.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ56375.1}.
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DR   EMBL; JYDW01000095; KRZ56375.1; -; Genomic_DNA.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054721};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRZ56375.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2275   2294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2306   2327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2333   2353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2360   2380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2392   2415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2435   2457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2537   2556       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      126    180       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      252    308       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      315    390       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      396    453       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1154   1174       {ECO:0000256|SAM:Coils}.
FT   COILED     2675   2695       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2696 AA;  310024 MW;  D1BC7B9E02B70698 CRC64;
     MSAVDVFSST FLHIGDEVSL YAEGSDGTNG FLSTLGLVDD RCVVRPAFGT PENPPKKFRD
     CIFKICPVRR YAAQKQLWAE ERTRQTNGMS SMTLDMMMRL KFNFRVEDAA EKEREQNQLE
     FEKTVGQIVQ YGTTLQLLHV KSNKFLTVNK KEPARVDRNA MKVTLDAQGN DGSWFTVEPF
     YKLRSLGDNV VAGDRICLVP YYVAQIPGSQ KHQLHVSSLS LAEDSESKEV NCLNDQTCWQ
     VLLFLEYREN LPDVLKGGDV VRLFHAEQQK FLTQDSRNGV QTVFLRVTKR DQALEATSSK
     ALWEVEVIQQ EPHKSGAAKW SSTFRFKHLA TDMYLAVLED EQSKKKPFPM SKEFKKKSSK
     SSSMEPTYSL VSVIPASPRD PATLFQLDPT TLTKMDAYIP RQSYIRLKHV QTKNWVHSTT
     TRCDPEKGDE SVMLKLGCSN WKEDKEAFAI LSVMPGEVRD LDFANDACKA LADFLQRIRH
     GLNVMKEKGM IMELLAELIY FVTNAKNHLE DPLKIKPNKV NRNRQKLLRE QKVLAQIFDL
     LRAPFESRKD QRPLFENPSV LSKPGNESFK RMFQLMYTVL RFSQQSYRRN QVYIAERFID
     IQHQIGHGLM AEDTITAVLH DNAKLLETHV EKTHIEKFIE LVRQNREGRF LDYLTLLCVC
     KNEANKKIQE LICLLVLNDA NRDILLETRM FGDQVFIGWL NDESEELEKL AYETMNSPEA
     ERIVNYYKHQ LDLFSHMCLD RQFLAIDPPA NKHLLNLSQE LPISVILRCM VNERLPYDLR
     ANFARLMLHL HVITDLQEVM PVRYARLWKE IPETVSVEKY TNEEIYSFNQ KQRRLFARSR
     FTGLLTYVEE YLRHVKTAKF SHKAQNVFTL EIVNLAHALV KFGFYSLPEL LVLAQDLLDI
     LDNCSLDMER VSNGAVVGAV VPNRTEENMK MEVSSFIESE KQPSDHEDGK TVNLKTKLTI
     VEILQYVLNV RLDYRITYLL SLIKKEYASS DTGDVGFYED LDDLKITQFA HEVFYSKSHC
     VEVDVEKEDF NCRLELGREN GKQLLRILLQ IMLSDYPPLI SLGLSVFYQS FNQRNELVQA
     LKQLQLLVSQ MDVQNYQQVH RDLVLMKNLV EKSELWVYSA KTGSQKRSLF PITNDKKSTE
     DEPLQRYDND LVELINVEEE KKNMMKLFKE LNCKYPMSSE HCRKLLSDIL NNWVKLCYAD
     ERRPDGRNQQ LLRNMRVYEV VIEFLSIPFD KKIDSEMPKL FDLAHQFLCG FCNDNEENQR
     LLHQRLSLNT DASKCDYLAI EEPRDIETLC AIFRGNRELC ANVSDQLIQH VVHLIESKGR
     NAIFLQFLQT LIPEERTISL TQEKISQVIS TSSEDVCLFY TDSAGFEAMM SLMKQSVDLS
     DLCNPLRYHI ELVRLLALCT VGKNVTTELQ CASHIPLEHI VRVITDEQCF YEIKEVYLQF
     LLHCYIDTDA DMKDMYCDDC MAQILANVLD DVEQVLLLLL YERGPSINGS VERYICLTVT
     KLLICFFEQP CAQCFSDPKH ENGIFGRLLE ALGRLQSIDW LRRQNAIYKS NLINCVETMC
     KFAIIYLFSF PCFYWIGAHD QRLAVTVDMI IRKEGKSSKW TKLKKAKYFV TQAAHMTRKG
     HDFNNIVDCF HEIVCRMEDL FGPMARAETM VAVDVLHYPD LTFYDTQSNM KRYSDGEFVT
     KLIKHCRLLA YDKNEQLCIK LLDTIRSMIP AEQDLDTSTM NSRKDLLLQY LGIHGPGRSG
     KAKSFKDDDQ ERWTTMLKKI LPQNITSVQC SLNAAGASKL VIDLIVHCSS ENIFIAAVEL
     GKTLLEGGNR VVQNSFLECL TSGGVGENFF RVFNEKMQRA QNKLRSSILS RRDRIGGSRM
     TSRSFMSGSS QTSAVGQAHD EAIRKIQDQL KLWSDDDWVG GSESSDIRTE RCWREQDKVD
     ADFLLPAEVT IMEPILRLLQ LLCENHNPAL QNFLRCQENR TNYNMVTETL MFLDTICGST
     SGSLGLLHEI NEHNVSLVNQ ALISLTEYCQ GPCHENQNAI AMHESNGLDI IISLVLNEIM
     PLAEKNIQLA LEIKSNASKL LLAILESRND CDNAERILRN MARMAGGAEQ LVSAITDVFK
     LPEISFNHSG YAEKIASQFD TPKIVFETKT DINGNPVEND GYCEVSPSEV GHNIYILAHQ
     LSKYYPKLNS MLKPSNARDE ISRSALQFYT DHTAHIEVVR SDRSLELIIF PVPHVCKFLT
     EETKERVFLK TERDLQGSKV PEFFANFDTL YNEIVWQQKL RDKPWLYKCS RSVPIWMRMS
     FIFAMILNFL VALFYPFDSA FGGSGFYLLC LLATTTYTFT APTWTAVAVT STFVASSCVS
     LFGVTVASYL FGLLQIANNI VHTVGIIGSY GPMKLTLASF LSNSNVVYNM FYLLLCLCGL
     FVHEFFYCFL LFDIVLHEET LCNVIRSVTR NWRSIALTGI LAVILVYTFS MVGFVLFSND
     FWIEVEPNDQ TCAQSENCTE TTNVPGEPVK VPFCESLRTC ILAVLRWGLS SGGGIGDVLR
     KPHPQEPLFY MRILYDLSFY FILIVIVLNL IFGVIIDTFA DLRNEKQENE EIIRNTCFIC
     GLERSHFENK PVSFDEHIKN DHNIWNYFYF YVLLNTKSST EFTGPESYVY DMIKEGNVDW
     FPRMRTMKLA IQEGDSEQTE VKILQRMICE RQEEISNLAA RIDELKQMVL KLSRSK
//
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