ID A0A0V1LFN4_9BILA Unreviewed; 1050 AA.
AC A0A0V1LFN4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=tubulin-glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00026108};
DE EC=3.4.17.24 {ECO:0000256|ARBA:ARBA00026108};
GN Name=Agtpbp1 {ECO:0000313|EMBL:KRZ58320.1};
GN ORFNames=T02_14321 {ECO:0000313|EMBL:KRZ58320.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ58320.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ58320.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ58320.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] +
CC H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-
CC glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA-
CC COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555,
CC ChEBI:CHEBI:149556; EC=3.4.17.24;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793;
CC Evidence={ECO:0000256|ARBA:ARBA00024524};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ58320.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDW01000059; KRZ58320.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LFN4; -.
DR STRING; 6335.A0A0V1LFN4; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.60.40.3120; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR12756; CYTOSOLIC CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR12756:SF11; CYTOSOLIC CARBOXYPEPTIDASE 1; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|EMBL:KRZ58320.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000313|EMBL:KRZ58320.1};
KW Protease {ECO:0000313|EMBL:KRZ58320.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 760..916
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|Pfam:PF00246"
FT REGION 1026..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 120431 MW; B7469C4C50D8387B CRC64;
MANAVELCRK LCQQHTIGVN KDAEEWSHLA KQLHTKCSVD ANDKSVQELW DNFENIDETL
LLNFLLCFEH CRNSEAIVWF TKILQQFISR PSADPKSRLQ LMAKLNGVSF LCKCLRWFVR
KFDETDEMIE VIQALIPIIQ IVGGVDGRFF MKVRFLGLLD MCINVMCNTA QYPLTESLLD
FLAFACRSGQ NASALVKNEM MVPFLKKIFA GCEKTTPSVI RKYAELLFLM AKPKKTRKSL
VSQGIIPSVL ELFRAFFGKD DNISQINCNA ALGTLRLLTS TISGRQNLVA CNGLEIFRDL
IRSFDESEAS SPLCSHMYHS ISSLCIRCLP MRPLPIDNMK YPVDVSIVEI QHSTPDPPEA
VSDSEDDISV AAGFLTDTDD EAMSRASQSE KPPIPLRIFQ KETHWYRFLT RELDYGTLLS
KDGTFGNVSA KQTDNMLFEM ADLENFMLEI NQRQRRRSIS SLREIRLSGK HRSITEQLLE
KSQSGMPTWY HWIDYCCQAV STRSVIPFES LGYPDMHGCY PNLPQQKLKC YPNALLNMVG
HLLERLESNK DYIPKVVYDL DQLVATRRTY NTSKFILNND IVKLGRSNPN TTSLQFESRF
EGGNLRKVGP YEYDLILTPD TNQMNEYYHT YYFQVSNMLT EISYTLNIIN CVKTRSLYNS
GMQPLVFSVT EALLGRPGWV RIGGNCVYYR NFYSRGSSST AAKSSETVTS YYTASFNVHF
RHRYDICYFA YHYPYTYTML KTHLVKTNQL LSLKKDIHFR TDVMCHTLSG NPVILVTVTE
LGDRIQLKSR DIVVLSARIH PGESNSSWMM HGMINYLISD HPFAKLARSK FIFKLIPMLN
VDGVINGNHR CSLAGKDLNR QWVAPERSMY PSIYHTKNLI SYLHRIGRTP FVKFVYCDFH
GHSRKMNVFL YGNNPNLSWY TGDRLQKHGF EFYQFPEILD ETSTAFELKY CAFTIKKNKE
GSARVAIWRD TGISRAYTLE ASYAGFDTGG YKGHQITTRD LIEMGEQFVE SLVRLKKSIE
QGKSPTRRFE IGAEQKETET EKKKNSVAVE
//
