ID A0A0V1LHB8_9BILA Unreviewed; 1634 AA.
AC A0A0V1LHB8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Tensin {ECO:0000313|EMBL:KRZ58936.1};
GN Name=TNS {ECO:0000313|EMBL:KRZ58936.1};
GN ORFNames=T02_1338 {ECO:0000313|EMBL:KRZ58936.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ58936.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ58936.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ58936.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ58936.1}.
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DR EMBL; JYDW01000050; KRZ58936.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR CDD; cd01213; PTB_tensin; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR PANTHER; PTHR45734; TENSIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 246..376
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1322..1404
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 415..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ58936.1"
SQ SEQUENCE 1634 AA; 182504 MW; 876F976328295A0D CRC64;
MSWNERWKLS RSLFAHNRML IIRKSVARMR GGNGNLSSVQ LVFFCCSCCC PIDFIYKVQH
LHAVLPSPGN IVKSSQRTRN LKVTRNNSCQ PSSMLTFAFA GCDDLYSKSV QLTIKMLASK
HDGKFKIFNV SKERSELANL NVFECGWPEC LAPALEKLCT ICKEMDRWLE LSTENVVVIH
QKGGFRRAAV VVSAFMHYCS ICASESQMLE HLAMQQYCKQ HSLLPSQRRY VQNFANLLSE
RIQVNSEPVV LYTLVVRGLT KRCPVYFKIY GKMVPVFTSN VVSGNAAEVL VARFRPPVSL
RGDILLKCCS AEDEFHQKCT LFQCQFNTCT VNNHSCRKIV FKNDELDYPI SENLSLELFC
AIIEPNCKSE IYPTDDNGNN SSNLSFNTSN IEPVYLEPST DNSFNSFEWF YDHNSSNEDG
SKAEQQSSGG TTLAMRRRRT ATTSPPRDAD PILEPDPEAD LDVDHDRATE AGKDNGRKKR
WLSRGSVESG RRDVEPALER PVVVDVRGKR ASFDVVTADS LGIVDLSPFR VGRAGVDRET
RAPHWAPPQT RRVIDTNYGP FESPFRPPAV VPPVKRAASP APVRVHHARA SPTVDKGDID
VDLVGEDRYD PQSRAFSYVP AQSLEEHFRA PKKPTKLVPA FKYTDNWTVA DEPLVTVEED
PASARVPNFD DLCDPNFYLN FDNGRLSGTA TESHNGAETD HHALSLCTDV SVDCPIGDQG
SNAWGADDND PQQQQQPAAE ASSKPSSTRH PSTFHSNNYH SPLSAATLDS RWSPSPSSRG
DFHFDDLTLG LEPLQTRRYQ HRPGQQLLLF DCSEPTTPRP FNNRCPSPNF YRNRQKLQVE
TRPVYTPTAW EERFLGGLGD QWDDSQRVSM SRRPLYYGNS LPEWPAESDA DSISAGGPVD
SESWLDLQMQ KLKIRREVND PARRRRREQE RLLLEELKQV QHVDGGRGRF GRHGAVAGAV
AGSKGAPLMD ESTASAVSSI SNSSPGRANE ESHTITNNNN TATTTVTTPL HPGFTRRKTN
NANTTTVPTS DHDTSPLLDV QSTVGRNRDG LWSSSSSSHR HACYNPHQTN FDHCYYYSNT
LSSTKSASSP KSILKKPKSF PAQPFVSPSY QATEELQSGN YYHDQVDGPD SSSYLKSRID
NTLASTDQPD YASSYMLNSP ARVETPAFPV RRMETPLPYH PLLYAGASTD DSRMMMSRVQ
NKPPPPPPPM SIRSLSPGSH YYAHSVRSSL ASLLVASQPA SQKAYSFCLL FYVIVVDHRN
CATTERSFIH STMKECLSKV DFFVKIDPPP PTVSNMEEDG NSETMEVVHH HPVFVKDTSK
YWYKPQISRE ETISVLKDKQ PGSFIIRDSS DGSELVRHFL IETTAKGVKL KGCNNEPVFG
SLAALVYQHS ITPLALPCKL LLPDYDPAVS VEQVTTAQQL LEQGAACNVT YLYSNATESL
TGPEAIRRTI DSALVLSSQK KIEPLNVHFK VSSQGITITD NARKVFFRRH YPVQTITHCG
LDPENRQWCC NSNSGPARIY GFVARKSLAK SENVCHLFAE LEPEQPASAI VNFVNKVIIN
PNRSHVSSSF MAVVALKSLC QLVTVHHHHH HHQYPGDHRT SIAYLRVGEE ASSSRLVVFI
DEVKKEKTNS SIYT
//
