ID A0A0V1LIP5_9BILA Unreviewed; 740 AA.
AC A0A0V1LIP5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transmembrane GTPase Marf {ECO:0000313|EMBL:KRZ59090.1};
GN Name=Marf {ECO:0000313|EMBL:KRZ59090.1};
GN ORFNames=T02_8179 {ECO:0000313|EMBL:KRZ59090.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ59090.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ59090.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ59090.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001270};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ59090.1}.
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DR EMBL; JYDW01000047; KRZ59090.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LIP5; -.
DR STRING; 6335.A0A0V1LIP5; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR PANTHER; PTHR10465:SF0; TRANSMEMBRANE GTPASE MARF-RELATED; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 612..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..350
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 384..411
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 683..710
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84632 MW; D3CC8BA8C0D94478 CRC64;
MDLPSINVNK STPDSRGRSK SLRPPEAVNA SPSPLHKFVE AKGKIKDIFI RTEQCIDKVF
RAICEQSFNC DLVDADIVGR IENLKQGISS IGNILSRDHM KVVFFGKTSN GKSTSINAML
RSKVLPTGMG HTTRCFIQVE GTDAAQKYIQ FDNCSDKLDV ETIHQKASAF CNSDLGEDVM
VRLYWPKSDS TLLQNEVVLL DSPGIDVAPQ YDEWINKHCG DADVFVFVCN AEATLTETEK
SFFRHVKDKL SKPNIFILNN RWDASVDEPE FIDQVREQHM NRCIDFLVND LQSCTEKEAR
NRIFFVSSRE MLYTRLKQKG IHSPSGASSA PPERFEERCM EFQNFERQFE LCISKTAIVT
KFYSHVEKGK AICEEVCELL DTLLVKIKAE LKEKSERLNG MESSYKSAEE DVVSCLSSAS
GVVEDLSKKV RKRISSEFDC QTNRFDAMLE HFLLEFSSDP DRLKDYKKKM IKFVDNVLNT
EFIDSCTGRL LPEVYKEEQS LEMHFLSCLP PSCRDNILSS NPKRAPFKFS FVIPCDQLFK
DFEEHLEFQF SLGIAHLMRK LSSYKCLDFH SNKAVQGEEM YAQSSAVVRY ASAVADGGVG
IVLLLALIKR TVGWPVIVTI ISIYELIYLY ERLSWNEKAK ERKFKRQFSD HLSRKLKIME
VTIISTFQQQ IQREIDDLAC RLDAVATRAL SETKDEIKAL EKQVAVLEKV TSEYTPVKKD
FVMLQGELEN FKNSYLRPYL
//
