ID A0A0V1LJ67_9BILA Unreviewed; 3817 AA.
AC A0A0V1LJ67;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Cubilin {ECO:0000313|EMBL:KRZ59086.1};
GN Name=CUBN {ECO:0000313|EMBL:KRZ59086.1};
GN ORFNames=T02_5423 {ECO:0000313|EMBL:KRZ59086.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ59086.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ59086.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ59086.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ59086.1}.
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DR EMBL; JYDW01000047; KRZ59086.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LJ67; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 23.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 26.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 24.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF07645; EGF_CA; 3.
DR SMART; SM00042; CUB; 26.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 8.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 26.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 26.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 132..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 170..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 266..305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 350..394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 397..434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 435..472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 478..600
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 604..724
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 730..877
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 878..994
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 998..1113
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1119..1235
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1239..1354
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1355..1482
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1484..1618
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1622..1749
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1750..1863
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1867..1977
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2140..2261
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2262..2377
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2381..2505
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2507..2624
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2628..2745
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2750..2867
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2869..2984
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2988..3107
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3108..3221
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3223..3343
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3350..3466
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3470..3582
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3585..3698
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3702..3813
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 201..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 462..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..757
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 1355..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 1484..1511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3817 AA; 428181 MW; F1B0EF03F1A5333A CRC64;
MPDVTHHEIN FRARILIHDG NIFFHPGENK NISFVTNHHG SITFGDVDIN SVATLNVVNA
LKHRLLYLET RQNISVEQLH GMAQSQSRLQ VSLQTIQAQI ESFTSPKDYS QPMQKKLRKL
IRNFNAVRKS LSKNECDSSP CQNGAMCIDA YERFYCICSM EFTGPTCAED IDECTLYKDT
DLGCQNGGTC LNTHGGYRCQ CPPNWHGYRC SESHDSCKAA SPNALCGPHG TCLPLANPHA
GQASYSCICE PGWKSSDSIT NPYCIDVDEC LSNPCFHGVT CINLPGSFKC GSCPTGYTGN
GLQCWDINEC SENNGGCSTN PKVQCINTYG SFYCGSCPAG YEGDGYSCSK LSMCERNPCH
ASATCINMPE SPKGFRCQCP SGTVGDGIGL LGCQLSQEDP CTPNPCLNGG ICQAYSSSRF
ICHCKPEYVG DRCDEFTSCH SSPCQNGGTC VSNPQGGYTC HCKPGMNGKF CEHEADTCDK
FYEQNTGTIQ HPLESDTYNS LQTCSWTITV EEGKIINATF PLFDLEKPVR ATSKICPFDN
VTLYDGADDS TPKIGSYCGN KGDLIAPEEY IITSTNKLHV VFQSDRTFSG AGFKLHWDAV
IPSCGGRIYK TSGYLKSPNY PGGYPSNSHC RWTLITQPGF HYKVKVSNLI FNLEDSDCAA
DFLEIRDGSR IDDPILARHC TTINKPMDSV YTSMPYVTVY FRSSENRKQI TQSDGKFLIE
YNVQEVDSHC GGVIKDMHGT VESPNYKNGF YFHDITCIWV FDSSNLSPSK VKLTFVEFDV
RGTYMAPSWW RYRHSSPFWT RRRVGSAVTG LIHHGPYCQE DFIEIRDGGD ENADLLSYYC
GDFEPGVVES SGPKLYLKFK TNNKNNGRGF KLTYDMVCGM DIKDSNGTIQ SPNYPDPSLQ
PMTCEYKITV APTSAIELTF IESNLGNGYE LTSQACTENY IELQSGIADV WFNRKFCNAP
LWPPFITAGS YLKIKFVTNG STKNRGFQAQ YRTYEIGCGG VYNSKHGVIT SPNYPDRYIQ
NLHCIWKIAV PRGLKVKITF TTFALEESPN CLYDYVEIYE TYRSKNESTG FIGKYCGHLN
PPPLISPSNE MTVLLHTDAN INSGGFELRF DGINTTTHCD FTFTESSGVI TNTGYPLHVT
QPMTCEYHIR IQKGYRIRLF NFNYSLPCNR GYLEFRNGPL ITSPPFPGIP KSQICDDVEI
DTFKSFGNMI VVLFKSLTSS LYYRPLWFYF QYEELAESCG GMISDISGSI ASPNYPLKSS
HAYDCLYHIV VSEGNRIALF LLSFEGSVHP NSACTTYDVL EITDGRFHSS PTIEKVCHSD
TTTRVFTSTS HEMSLRYMHY LSSTSGFLVT YNTVCENIKL FGIHGRIKSP GFKSRISKAR
RCEWIIETYP GNMLRLHFFY FSIQDESSDS LHECTKSSLK IISADGNVIL SKRAANVTLK
DPAFCDISEQ PTFLFVESNM VKIEFTAPQN SLDHFGLEWG TDGCGMKVTE NSGKLIITNN
TGNPASELKV CAWTFHAPLG QKIELQINYL GILRSQILDC SYPVRYGDLF DLDAFHVFNG
LNNASGLSFK TICDHINRNN PLIIDSVSNE LFVLFVYHHY SSVPEHDGTI LHVEYKFKDG
GCGGVHTELQ GSLQTPGYPG RYQREIECNW KIQVPHGYLV KIEIKDLNIG NYFTKCRWSV
TNEGYLAIYD GPEANTSYPM LGMFCSNVVP ENSTVITTGN EAFVRFVGTK NNANSHKDAR
GFLAKYEAVC GSKLRASSTR QSFGSLKHLE SQECEWLIET GEVGQKITLN VDYLSRSMSC
ELNYIEIFDG PEPRNETLLS QLCDASKSLS FKSSGNYLYL KLHSHLTISP TTAMRFSFSY
YLSDSQCGGD YYSLSGRFSS PLYPDLYPSN VDCVWRIFNS LGSRVRLTFL SFKLAESEYC
EKDFVEVREK DQGGRLLGRF CGEQFPPSIV GWESVWIRFR SLPDSSEEGF QLHYELLMGG
DLEGKEGRLT SPFYNYNSLW NSGDYMQPEI ININETEIYD QDKEYIWWRI STEVNLVVEA
TLSNVILENY WWLHGLNMLN EGEYLQIYDG FCDLTVISKP EDCTLIQSIE YATPKVSVMS
KTNHLSVLLH LTTGGTPKFE LSWNSAIANL QEDELENSNC RYHLTATKER KNITSPGFPL
EYSPATECTW WINHPKNHSV IIEIIMLDIE AHPKCSYDAL EIFQAPSMWY EDFQQTYQMK
YCGHHAPNGT ETYSHESEVL VHFHSDHSFA GKGFVMEYWL GCGSVFSLTD SAQILTSPNF
PEFYENNQRC NWMVVAKTGR AIKLHIDILQ LEDSANCTKD YLQIYNGPEN DSPLLGHYCG
STLSGEPLIS TSNILRVLFV SDELVNAGGF QLTVEEMKLD CSSDSLVLVD DSSVGELYSP
GYPHIYRHSM DCLWTIQSPS GTRIQFDFDP DSFDIEQAPI SSEVGCIYDY VEILDGATIA
ANSLGRFCGN RVPETIQSSS NYMTVRFLSD ESAAKGGFKA TYRIARCGGT VVGRQGVITS
PNYPHHYEHL KECEWYVRVP EGGYINFTFA DLNFGGVGRR NASECTADFI EIRESNKTGP
LIGRYCSGAD KNKHGRTKSN LMYIMFKSDA SLNGRGFKLL YNYTSYECGG HLNQPNGQLM
TPHYPDFLSG SLFCEWIIEV PLSRRVTLTF EDFSLPAGLM HFCFNAHVTL YSDPEAMNPI
VDAAMCGADY ELPMSFRSTG NVMVVRIETE TASDARGFRA TYHSDEPAEC GGVINSPTRI
GYFPKENSTI PNGIYCRWHI KNPNKKDSTI VLKIHHLNIR SQDTCYFDYL AIQGVSIALG
VEDERKKLCG ELRDVTLTYY YREIDLYFVS RWYSYYMTNF TMDISFSKCG GILTATEGII
TSPGYPQIYN YDSHCEWLIV APQGSEIKIE FKDIQLEHHQ LCQYDNVTVH NGRFTSSPIV
RTYCDSYDTI PDNYFVSSSR FLLVVFQSDN VNSNRGFKLE YKTISPGCGN VIHGAEGYIV
SPNFPKNYGS NLYCRWEIIV PNAFHVKLHF VIFDVSPSEN CTKDFLVIEE TQNRTASIFD
HSWSVSRRLC GYAVEGPFVG KNDRVRITFQ SDASIESTGF NISWTSDCGG VYKDPKGIIS
SPYYPNDYGN NMHCEYIIDP IHSNEYYVYL EFTHFQLEET GYVDNCLDYV EVTSLAEGNV
LLNTCGQVIP ERVNGVGPLK VIFHSDSLVT NVGFSAQYGS TGCGGTFNLS SDEFFSRMFG
IGSIPFPPYH NQMNCTWLIS APEGHVIVFK LSQLSIEETD YCEYDFLQVH DGLTTADRSL
GKYCGSTLPD RAAKSTSNHM LVRFVTDASL TEPTAFEGTV TATPGPEMGC GGSINVTTAG
TIRSPTQENS ALYPAYLDCH WILLAPIGRV ISVQIVEFSL EASNLPMCFD YLEIQDGHYD
SGSLIGKYCG TMQPWRFTTS TDKLQLHFVT DDQIESTGFV LKYELKPALC GAALTPLKQR
QFVHHTQSAS NHRCRWGIES AGDGMKLLVQ IVHLNVEPAE DDCSTSYIEI SETPKDKNAR
KFRDCGTSSG FKIYSKKAIL ITSALSTLPM SRISFNISYQ MIDECNETIA VAVDQQDGEL
TSPNYPNSYP HGAHCTTKLI AAPNYKIRLY FNAFRFEPER GQCKNDILTI SQPNSKDLQY
CDTNIPPTLT SKTNQLTLHF NTDNSVAYQG YSITYLVTDQ DCGGTIQLAS GSITSPNYPG
DYPPRVRCRW LISVPRGSWI SFHVAHLKMD PTCDDQSDRL ELRSANVDNQ EPQIYCGEQQ
PSTGVIMMSN QVEVLFTSGD SKANSYEVVV MDVGNRK
//
